Key takeaways
Climara (estradiol) and Depo-Estradiol (estradiol cypionate) are both estrogen replacement therapies, but they differ in their forms and administration. Climara is a transdermal patch applied to the skin once or twice a week, while Depo-Estradiol is an intramuscular injection given every 3 to 4 weeks. Climara is available in both generic and brand-name forms, which can make it more affordable, whereas Depo-Estradiol is only available as a brand name injection. Climara can treat a wider range of menopause symptoms, including vaginal dryness, which Depo-Estradiol does not address. Both medications carry similar risks, such as increased chances of certain cancers, blood clots, and strokes, and both require the addition of progestin if you have a uterus to lower the risk of uterine cancer. However, Depo-Estradiol is noted for its convenience of monthly dosing and effectiveness in treating severe hot flashes.
