Key takeaways
Climara (estradiol) and Estring (estradiol) are both estrogen replacement therapies, but they differ in their forms and uses. Climara is a transdermal patch applied to the skin once or twice a week, while Estring is a vaginal ring that you replace every three months. Climara treats multiple menopause symptoms, including hot flashes and night sweats, and can also help prevent osteoporosis. In contrast, Estring specifically targets vaginal symptoms like dryness and burning. Climara may require you to avoid swimming if you use the once-weekly patch, whereas Estring does not have such restrictions. Additionally, Climara is available in multiple strengths, allowing for dose customization, while Estring is only available in one strength. Both treatments carry risks of serious side effects, such as blood clots and certain cancers, but Estring might not require a progestin if used at a low dose.
