Key takeaways
Climara (estradiol) and Activella (estradiol/norethindrone) are both used to treat menopausal symptoms and prevent osteoporosis, but they have some key differences. Climara is a transdermal patch that only contains estradiol, while Activella is an oral tablet that combines estradiol with norethindrone, a progestin. Because Climara only has estrogen, if you still have your uterus, you will need to take a separate progestin to lower your risk of uterine cancer. Activella already includes norethindrone, which helps protect your uterus. Climara is applied once or twice a week, whereas Activella is taken daily. Both medications can cause weight gain and increase the risk of blood clots, heart attacks, and strokes, but Activella may cause more side effects since it features an estrogen and progestin. Additionally, Climara might not be suitable if you have liver problems, while Activella is not recommended if you have a history of certain cancers or blood clots.
