Key takeaways
Estring (estradiol) and Divigel (estradiol) are both estrogen replacement therapies used to treat menopausal symptoms, but they differ in their forms and specific uses. Estring is a vaginal ring that you insert into your vagina, and it primarily treats vaginal dryness, burning, and irritation. You need to replace it every three months. On the other hand, Divigel is a topical gel you apply to your skin once daily that targets hot flashes and night sweats. Estring is more convenient for those who prefer less frequent dosing, while Divigel offers a daily routine that might be easier for some to remember. Estring is only available as a brand-name medication, which can make it expensive, whereas Divigel is available as a low-cost generic. Both medications carry risks of serious side effects like blood clots, strokes, and certain cancers and should be used at the lowest effective dose for the shortest duration necessary. Additionally, if you have a uterus, you might need to take a progestin-based medication with either Estring or Divigel to lower the risk of uterine cancer.
