Key takeaways
Estring (estradiol) and Depo-Estradiol (estradiol cypionate) are both estrogen replacement therapies, but they have different uses and methods of administration. Estring is a vaginal ring that you insert into your vagina to relieve symptoms like vaginal dryness and burning due to menopause. It needs to be replaced every three months. On the other hand, Depo-Estradiol is an injection given into a muscle, typically once a month, and is used to treat hot flashes, night sweats, and other low estrogen conditions. Estring is more convenient for those who prefer not to take pills and works directly at the site of application; while Depo-Estradiol can be administered at home, it does require learning how to give yourself an injection. Both medications carry risks such as blood clots, strokes, and certain cancers. Additionally, if you have your uterus, you may need to take a progestin-based medication with either treatment to lower the risk of uterine cancer.
