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Lyllana vs. Climara

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Lyllana

(estradiol patch)

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Climara

(estradiol patch)

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Summary for Lyllana

Prescription only

Lyllana (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, due to menopause. It also helps prevent bone loss (osteoporosis) after menopause. The patch is a type of hormone replacement therapy. One of the benefits of Lyllana (estradiol patch) compared to oral estrogen pills is that it might cause fewer side effects. But it can still cause common side effects like breast tenderness, headaches, and back pain.

Indications for Lyllana

Pros and Cons for Lyllana

Pros

  • Typically has fewer side effects than oral estrogen pills
  • Delivers a consistent dose of estrogen over time
  • Good option if you have trouble swallowing pills
  • Available in different strengths, allowing you to customize your dose

Cons

  • Commonly causes headache, breast tenderness, and back pain
  • Need to apply a new patch twice a week
  • Raises your risk of certain cancers, blood clots, and strokes
  • Might need to take it with another hormone called progestin if you have a healthy uterus

Common Side Effects for Lyllana

  • Headache (up to 50%)
  • Common cold symptoms (up to 20%)
  • Breast tenderness (up to 17%)
  • Sinus swelling (up to 13%)
  • Bleeding in-between periods (up to 11%)
  • Depression (up to 11%)
  • Back pain (up to 11%)
  • Sinus headache (up to 10%)
  • Indigestion (up to 9%)
  • Weight gain (up to 9%)
  • Joint pain (up to 9%)

Warnings for Lyllana

  • Blood clots and related complications (e.g., heart attack, stroke)
  • Uterine (endometrial) cancer
  • Breast cancer
  • Ovarian cancer
  • Dementia
  • Gallbladder and liver problems
  • Vision problems
  • High triglycerides
  • Low thyroid hormone levels (hypothyroidism)
  • Fluid Retention
  • Severe allergic reactions
  • Worsening of other health conditions

Summary for Climara

Prescription only

The Climara (estradiol patch) is a once-weekly hormonal patch that relieves menopause symptoms and treats low estrogen levels. It can also help prevent bone loss (osteoporosis) in people who have gone through menopause. The patch is a type of hormone replacement therapy (HRT) and typically has fewer side effects than oral estrogen pills. You'll apply one patch to the skin of your lower stomach or the upper buttocks once a week. Potential side effects of this hormone patch include breast pain, headaches, and stomach pain.

Indications for Climara

Pros and Cons for Climara

Pros

  • Relieves multiple menopause symptoms
  • Only need to apply once a week
  • Might have fewer side effects than oral estrogen pills
  • Available in different strengths, allowing you to customize your dose

Cons

  • Commonly causes breast pain, headaches, and stomach pain
  • Can cause skin irritation, redness, and itchiness at the patch site
  • Raises your risk of certain cancers, blood clots, and strokes
  • Might need to take it with another hormone called progestin if you have a healthy uterus

Common Side Effects for Climara

  • Breast pain (up to 29%)
  • Headache (up to 18%)
  • Upper respiratory tract infection (up to 17%)
  • Stomach pain (up to 16%)
  • Swelling (up to 13%)
  • Back and body pain (up to 11%)
  • Depression (up to 8%)
  • Vaginal discharge (up to 7%)
  • Excessive gas (up to 7%)
  • Itching (up to 6%)
  • Nausea (up to 6%)

Warnings for Climara

  • Blood clots and related complications (e.g., heart attack, stroke)
  • Uterine (endometrial) cancer
  • Breast cancer
  • Ovarian cancer
  • Dementia
  • Gallbladder and liver problems
  • Vision problems
  • High triglycerides
  • Low thyroid hormone levels (hypothyroidism)
  • Fluid Retention
  • Worsening of other health conditions

Prices with our coupons for Lyllana vs. Climara

Price Card Drug Icon
Lyllana1 carton / 8 twice-weekly patches of 0.05mg/day
$52.56$58.79
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Price Card Drug Icon
Estradiol4 patches / 0.0375mg/day
$19.39$36.91
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