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Compare Yuvafem vs. Divigel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Estradiol vaginal insert (Vagifem) and tyopical estradiol gel (Divigel) are both estrogen replacement medications used to treat symptoms of menopause, but they differ in their specific uses and forms. Estradiol vaginal insert is used for vaginal symptoms only, such as dryness or painful intercourse. It's typically insert once daily for 2 weeks, then twice a week therafter. Estradiol gel is applied topically to the skin once daily and treats bodywide menopause symptoms, such as hot flashes and night sweats. Common side effects of the vaginal insert include vaginal yeast infections and back pain, while estradiol gel may cause breast tenderness and abnormal vaginal bleeding. Both medications carry risks of serious side effects like blood clots and certain cancers, and you may need to take a progestin if you have a uterus to lower the risk of uterine cancer.

  • Yuvafem
    Estradiol gel (Divigel)
  • Yuvafem
    Estradiol gel (Divigel)

  • Summary of Yuvafem vs. Divigel

    Summary for Estrogen replacement
    Prescription only

    Yuvafem (estradiol vaginal insert) is used to treat vaginal dryness, irritation, and burning caused by menopause. It contains estradiol, a type of estrogen that helps raise your hormone levels to relieve these symptoms. Yuvafem is a generic version of Vagifem and is inserted into the vagina using an applicator. You’ll typically use one insert twice a week after using it daily for the first 2 weeks. Common side effects include vaginal yeast infection, diarrhea, and back pain.

    Summary for Estrogen replacement
    Prescription only

    Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.

  • Indications of Yuvafem vs. Divigel

    Indications for
    •Vaginal dryness, burning, and irritation due to menopause
    Indications for
    •Hot flashes and night sweats due to menopause

  • Pros and Cons of Yuvafem vs. Divigel

    Pros and Const for Estrogen replacement
    Pros
    •After the first 2 weeks, only need to use twice a week
    •Works directly at the site of application to relieve vaginal symptoms
    •Comes preloaded in an easy-to-use applicator
    Cons
    •Can cause vaginal yeast infections
    •Doesn't treat other menopause symptoms like hot flashes or night sweats
    •Must take a progestin if you have a uterus to lower your risk of uterine cancer
    Pros and Const for Estrogen replacement
    Pros
    •Relieves bothersome menopausal symptoms, such as hot flashes and night sweats
    •Applied directly to the skin on the thighs
    •Only need to use once a day
    •Available in multiple strengths to customize your dose
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Risk of exposing others to estrogen through skin contact
    •Might also need to take a progestin medication if you have a uterus
    •Need to wait for the gel to dry completely before bathing, showering, or swimming

  • Common Side Effects of Yuvafem vs. Divigel

    Common Side Effects for
    •Vaginal yeast infections (8%)
    •Vaginal itching (8%)
    •Back pain (7%)
    •Diarrhea (5%)
    Common Side Effects for
    •Abnormal vaginal bleeding (4-10%)
    •Breast tenderness (3-9%)
    •Common cold symptoms (4-6%)
    •Upper respiratory tract infection (2-6%)
    •Vaginal yeast infection (1-6%)

  • Warnings of Yuvafem vs. Divigel

    Common Side Effects for
    •Risk for blood clots and related complications
    •Risk for uterine cancer (also called endometrial cancer)
    •Risk for breast cancer
    •Risk for ovarian cancer
    •Risk for dementia
    •Gallbladder or liver problems in certain people
    •High triglyceride (fat) levels
    •Changes in calcium levels in certain people
    •Low thyroid hormone levels
    •Buildup of fluids in your body (fluid retention)
    •Worsening of certain other health conditions
    •Vaginal irritation with applicator use
    Common Side Effects for
    •Risk of blood clot
    •Uterine (endometrial) cancer
    •Breast cancer
    •Dementia
    •Gallbladder and liver problems
    •Changes in calcium levels in the blood
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Worsening of other medical conditions
    •Potential skin-to-skin transfer

  • Prices with our coupons for Yuvafem vs. Divigel

    Learn more about Yuvafem
    Learn more about Estradiol gel

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