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Compare Intrarosa vs. Divigel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Intrarosa (prasterone) and Divigel (estradiol) are both medications used to treat symptoms related to menopause, but they work differently and have different uses. Intrarosa is a synthetic form of DHEA that's inserted vaginally to relieve painful intercourse due to menopause. Divigel, on the other hand, is an estrogen replacement therapy applied as a gel to the skin to treat hot flashes and night sweats. Intrarosa is used once daily at bedtime, while Divigel is applied once daily to the upper thigh. Intrarosa is only available as a brand-name medication, whereas Divigel is available in both brand-name and generic forms. Common side effects of Intrarosa include vaginal discharge, while Divigel can cause vaginal yeast infections and breast tenderness. Divigel carries a risk of serious side effects like blood clots and certain cancers, which are not associated with Intrarosa. You'll also need to take a progestin along with Divigel in most cases, which isn't required with Intrarosa. Additionally, Divigel can transfer to others through skin contact, so you need to be careful after applying it.

  • Intrarosa (prasterone)
    Estradiol gel (Divigel)
  • Intrarosa (prasterone)
    Estradiol gel (Divigel)

  • Summary of Intrarosa vs. Divigel

    Summary for Synthetic steroid
    Prescription only

    Intrarosa (prasterone) is a vaginal insert used to help ease pain from intercourse (sex) caused by the thinning, drying, and inflammation of vaginal walls as a result of menopause. This medication is a man-made, plant-based version of dehydroepiandrosterone (DHEA), a hormone made by your body. Intrarosa (prasterone) is inserted vaginally once a day at bedtime. The most common side effect of this medication is vaginal discharge. There are currently no generic alternatives of Intrarosa (prasterone) available.

    Summary for Estrogen replacement
    Prescription only

    Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.

  • Indications of Intrarosa vs. Divigel

    Indications for
    •Painful sexual intercourse as a result of menopause
    Indications for
    •Hot flashes and night sweats due to menopause

  • Pros and Cons of Intrarosa vs. Divigel

    Pros and Const for Synthetic steroid
    Pros
    •Once-daily dosing
    •Only vaginal non-estrogen treatment for painful sex due to menopause
    •Plant-based ingredients
    •Not many side effects
    Cons
    •Might take about 3 months to feel relief from painful intercourse
    •Not for people who have or have had breast cancer
    •Brand only, no lower-cost generics available
    •Not for people who haven't been through menopause
    Pros and Const for Estrogen replacement
    Pros
    •Relieves bothersome menopausal symptoms, such as hot flashes and night sweats
    •Applied directly to the skin on the thighs
    •Only need to use once a day
    •Available in multiple strengths to customize your dose
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Risk of exposing others to estrogen through skin contact
    •Might also need to take a progestin medication if you have a uterus
    •Need to wait for the gel to dry completely before bathing, showering, or swimming

  • Common Side Effects of Intrarosa vs. Divigel

    Common Side Effects for
    •Vaginal discharge (up to 14%)
    Common Side Effects for
    •Abnormal vaginal bleeding (4-10%)
    •Breast tenderness (3-9%)
    •Common cold symptoms (4-6%)
    •Upper respiratory tract infection (2-6%)
    •Vaginal yeast infection (1-6%)

  • Warnings of Intrarosa vs. Divigel

    Common Side Effects for
    •Breast cancer
    Common Side Effects for
    •Risk of blood clot
    •Uterine (endometrial) cancer
    •Breast cancer
    •Dementia
    •Gallbladder and liver problems
    •Changes in calcium levels in the blood
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Worsening of other medical conditions
    •Potential skin-to-skin transfer

  • Prices with our coupons for Intrarosa vs. Divigel

    Learn more about Intrarosa
    Learn more about Estradiol gel

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