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Compare Divigel vs. Testosterone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Estradiol gel (Divigel)
    Testosterone gel
  • Estradiol gel (Divigel)
    Testosterone gel

  • Summary of Divigel vs. Testosterone

    Summary for Estrogen replacement
    Prescription only

    Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.

    Summary for Testosterone replacement
    Prescription only

    Testosterone gel is used to treat low testosterone in adult males. It's convenient to use because you only have to apply it to your skin once a day. But compared to other forms of testosterone, there's a higher risk of exposing others to the medication through skin-to-skin contact.

  • Indications of Divigel vs. Testosterone

    Indications for
    •Hot flashes and night sweats due to menopause
    Indications for
    •Low testosterone (hypogonadism)

  • Pros and Cons of Divigel vs. Testosterone

    Pros and Const for Estrogen replacement
    Pros
    •Relieves bothersome menopausal symptoms, such as hot flashes and night sweats
    •Applied directly to the skin on the thighs
    •Only need to use once a day
    •Available in multiple strengths to customize your dose
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Risk of exposing others to estrogen through skin contact
    •Might also need to take a progestin medication if you have a uterus
    •Need to wait for the gel to dry completely before bathing, showering, or swimming
    Pros and Const for Testosterone replacement
    Pros
    •Works well to replace testosterone in your body
    •Applied once a day to your skin, so it's easy to use
    •Available in tubes, packets, or as a pump
    •Some brand names are available as lower-cost generics
    Cons
    •Can cause skin irritation
    •Need to avoid skin-to-skin transfer to other people
    •Need to wait hours before you can shower, swim, or bathe
    •Have to follow specific instructions on where and how it can be applied

  • Common Side Effects of Divigel vs. Testosterone

    Common Side Effects for
    •Abnormal vaginal bleeding (4-10%)
    •Breast tenderness (3-9%)
    •Common cold symptoms (4-6%)
    •Upper respiratory tract infection (2-6%)
    •Vaginal yeast infection (1-6%)
    Common Side Effects for
    •Skin irritation
    •Skin rash
    •Itchiness
    •High red blood cell count
    •Enlarged prostate
    •Acne

  • Warnings of Divigel vs. Testosterone

    Common Side Effects for
    •Risk of blood clot
    •Uterine (endometrial) cancer
    •Breast cancer
    •Dementia
    •Gallbladder and liver problems
    •Changes in calcium levels in the blood
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Worsening of other medical conditions
    •Potential skin-to-skin transfer
    Common Side Effects for
    •Early puberty or development of male features
    •High red blood cell count and blood clots
    •Heart attack and stroke
    •Potential for misuse, addiction, and dependency
    •Worsening symptoms of enlarged prostate and prostate cancer
    •Liver problems
    •Swelling in the arms and legs (edema)
    •Breathing problems during sleep (sleep apnea)
    •High calcium in the blood

  • Prices with our coupons for Divigel vs. Testosterone

    Learn more about Estradiol gel
    Learn more about Testosterone gel

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