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Compare Estring vs. Evamist

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Estring (estradiol) and Evamist (estradiol) are both estrogen replacement therapies, but they are used differently and treat different symptoms of menopause. Estring is a vaginal ring that you insert into your vagina to relieve vaginal dryness, burning, and irritation. It needs to be replaced every 3 months. On the other hand, Evamist is a topical spray that you apply to your forearm daily to help with hot flashes and night sweats. Estring is more focused on treating local vaginal symptoms, while Evamist addresses systemic menopausal symptoms like hot flashes. Evamist can cause breast tenderness, whereas, Estring can cause vaginal yeast infections, discomfort, or pain. Both medications carry risks of serious side effects, such as blood clots, strokes, and certain cancers. Additionally, if you have a uterus, you might need to take a progestin-based medication with either Estring or Evamist to lower the risk of uterine cancer.

  • Estring (estradiol)
    Evamist (estradiol)
  • Estring (estradiol)
    Evamist (estradiol)

  • Summary of Estring vs. Evamist

    Summary for Estrogen replacement
    Prescription only

    Estring (estradiol) is an estrogen vaginal ring used as part of hormone replacement therapy (HRT) to treat moderate-to-severe menopause symptoms in and around the vagina, such as vaginal dryness, burning, and irritation. The ring is inserted into the vagina and stays in place for 3 months, releasing a steady dose of estrogen directly where it's needed. Common side effects include headache, vaginal discharge, and vaginal yeast infections.

    Summary for Estrogen replacement
    Prescription only

    Evamist (estradiol) is a topical hormone spray that helps relieve the hot flashes and night sweats caused by menopause. It's a hormone replacement therapy (HRT) that's sprayed onto the skin of your inner forearm once a day. The typical dose ranges from 1 to 3 sprays daily, depending on your symptoms. Some potential side effects of this medication include headache, tender breasts, and back pain.

  • Indications of Estring vs. Evamist

    Indications for
    •Vaginal dryness, burning, and irritation due to menopause
    Indications for
    •Moderate-to-severe vasomotor symptoms of menopause, like hot flashes and night sweats

  • Pros and Cons of Estring vs. Evamist

    Pros and Const for Estrogen replacement
    Pros
    •Can be inserted by you or a healthcare professional
    •Only needs to be changed every 3 months
    •Works directly at the site of application to relieve vaginal symptoms
    Cons
    •Can cause vaginal yeast infections
    •Doesn't treat other menopause symptoms like hot flashes or night sweats
    •Must take a progestin if you have a uterus to lower your risk of uterine cancer
    Pros and Const for Estrogen replacement
    Pros
    •Dries within 2 minutes, doesn't need to be rubbed in
    •Possible option if you can't swallow pills
    •Only needs to be applied once a day
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Need to use with progestin to lower your risk of uterine cancer (in females who have uterus)
    •Must cover with clothing to prevent exposure to others

  • Common Side Effects of Estring vs. Evamist

    Common Side Effects for
    •Headache (13%)
    •Vaginal discharge (7%)
    •Vaginal yeast infection (6%)
    •Back pain (6%)
    •Vaginal inflammation (5%)
    •Vaginal discomfort or pain (5%)
    •Upper respiratory infection (5%)
    •Vaginal bleeding (4%)
    •Bacterial growth in the vagina (4%)
    •Arthritis (4%)
    •Trouble sleeping (4%)
    •Stomach pain (4%)
    •Sinus inflammation (4%)
    •Nausea (3%)
    •Flu-like symptoms (3%)
    •Joint pain (3%)
    Common Side Effects for
    •Headache (up to 12%)
    •Breast tenderness (up to 7%)
    •Nipple pain (up to 7%)
    •Cold-like symptoms (up to 5%)
    •Back pain (up to 5%)
    •Joint pain (up to 4%)

  • Warnings of Estring vs. Evamist

    Common Side Effects for
    •Risk for blood clots and related complications
    •Risk for uterine cancer (also called endometrial cancer)
    •Risk for breast cancer
    •Risk for ovarian cancer
    •Risk for dementia
    •Gallbladder or liver problems in certain people
    •High triglyceride (fat) levels
    •Changes in calcium levels in certain people
    •Low thyroid hormone levels
    •Buildup of fluids in your body (fluid retention)
    •Worsening of certain other health conditions
    •Vaginal irritation and infections
    Common Side Effects for
    •Uterine or endometrial cancer
    •Breast cancer
    •Blood clots, heart attacks, and strokes
    •Risk of dementia
    •Risk of harm in children (accidental contact with medication)
    •Gallbladder problems
    •Higher risk of side effects
    •Vision problems
    •High triglycerides
    •Changes in calcium levels in the blood
    •Low thyroid hormone levels (hypothyroidism)
    •Swelling from fluids
    •Worsening of other medical conditions

  • Prices with our coupons for Estring vs. Evamist

    Learn more about Estring
    Learn more about Evamist

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