Key takeaways
Estring (estradiol) and Evamist (estradiol) are both estrogen replacement therapies, but they are used differently and treat different symptoms of menopause. Estring is a vaginal ring that you insert into your vagina to relieve vaginal dryness, burning, and irritation. It needs to be replaced every 3 months. On the other hand, Evamist is a topical spray that you apply to your forearm daily to help with hot flashes and night sweats. Estring is more focused on treating local vaginal symptoms, while Evamist addresses systemic menopausal symptoms like hot flashes. Evamist can cause breast tenderness, whereas, Estring can cause vaginal yeast infections, discomfort, or pain. Both medications carry risks of serious side effects, such as blood clots, strokes, and certain cancers. Additionally, if you have a uterus, you might need to take a progestin-based medication with either Estring or Evamist to lower the risk of uterine cancer.
