Key takeaways
Climara (estradiol) and Estrace (estradiol) are both estrogen replacement therapies, but they differ in their forms and uses. Climara is a transdermal patch applied to the skin once or twice a week, primarily treating multiple menopause symptoms like hot flashes and preventing osteoporosis. In contrast, Estrace is a vaginal cream used to relieve vaginal symptoms of menopause, such as dryness and itching, and is applied daily at first, then reduced to a few times a week. Climara is more likely to cause systemic side effects like headaches and weight gain, while Estrace has a lower risk of serious side effects because it is applied locally. However, both can increase the risk of certain cancers, blood clots, and strokes. Neither Climara nor Estrace are suitable for those with liver problems. Estrace can be challenging to use and may cause vaginal irritation. Both medications require a prescription and have generic forms available.
