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Compare Premarin Vaginal Cream vs. Evamist

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Premarin vaginal cream (conjugated estrogens) and Evamist (estradiol) are both estrogen replacement medications used to treat symptoms of menopause, but they have some important differences. Premarin is a vaginal cream specifically approved for treating vaginal symptoms, like dryness and irritation. In contrast, Evamist is a topical spray used to relieve moderate-to-severe vasomotor symptoms like hot flashes and night sweats. Premarin is applied directly into the vagina either in cycles or twice weekly, while Evamist is sprayed onto the skin of your inner forearm once daily. Both medications are only available in a branded version. Common side effects of Premarin include headache and pelvic pain, whereas Evamist may cause headaches and breast tenderness. Both medications can increase the risk of serious side effects, such as blood clots and certain types of cancer.

  • Premarin vaginal cream
    Evamist (estradiol)
  • Premarin vaginal cream
    Evamist (estradiol)

  • Summary of Premarin Vaginal Cream vs. Evamist

    Summary for Estrogen replacement
    Prescription only

    Premarin (conjugated estrogens) vaginal cream is an estrogen hormone cream used to treat adults with vaginal symptoms due to menopause, such as vaginal dryness and pain during sex. Depending on what you're taking the vaginal cream for, the dosage can be different. You might apply it in cycles (daily for 3 weeks, then no cream for 1 week) or simply just twice a week. Common side effects include headache, pelvic pain, and breast pain.

    Summary for Estrogen replacement
    Prescription only

    Evamist (estradiol) is a topical hormone spray that helps relieve the hot flashes and night sweats caused by menopause. It's a hormone replacement therapy (HRT) that's sprayed onto the skin of your inner forearm once a day. The typical dose ranges from 1 to 3 sprays daily, depending on your symptoms. Some potential side effects of this medication include headache, tender breasts, and back pain.

  • Indications of Premarin Vaginal Cream vs. Evamist

    Indications for
    •Vaginal dryness and irritation
    •Pain during sex caused by menopause
    Indications for
    •Moderate-to-severe vasomotor symptoms of menopause, like hot flashes and night sweats

  • Pros and Cons of Premarin Vaginal Cream vs. Evamist

    Pros and Const for Estrogen replacement
    Pros
    •Is applied directly into the vagina to relieve symptoms locally
    •Good option if for those who have trouble swallow pills
    •Smaller amounts are absorbed into the body compared to tablets or injections
    Cons
    •Applying the cream can be messy
    •Need to remember stop taking it for a week if your dosage is in cycles
    •Can take several weeks to improve symptoms
    Pros and Const for Estrogen replacement
    Pros
    •Dries within 2 minutes, doesn't need to be rubbed in
    •Possible option if you can't swallow pills
    •Only needs to be applied once a day
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Need to use with progestin to lower your risk of uterine cancer (in females who have uterus)
    •Must cover with clothing to prevent exposure to others

  • Common Side Effects of Premarin Vaginal Cream vs. Evamist

    Common Side Effects for
    •Breast pain (2-5%)
    •Headache (2-4%)
    •Pelvic pain (3%)
    •Vaginal discharge (2-3%)
    Common Side Effects for
    •Headache (up to 12%)
    •Breast tenderness (up to 7%)
    •Nipple pain (up to 7%)
    •Cold-like symptoms (up to 5%)
    •Back pain (up to 5%)
    •Joint pain (up to 4%)

  • Warnings of Premarin Vaginal Cream vs. Evamist

    Common Side Effects for
    •Uterine (endometrial) cancer
    •Breast cancer
    •Blood clots and stroke
    •Heart disease and heart attacks
    •Dementia
    •Gallbladder and liver problems
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Changes in calcium levels in the blood
    •Worsening of other health conditions
    Common Side Effects for
    •Uterine or endometrial cancer
    •Breast cancer
    •Blood clots, heart attacks, and strokes
    •Risk of dementia
    •Risk of harm in children (accidental contact with medication)
    •Gallbladder problems
    •Higher risk of side effects
    •Vision problems
    •High triglycerides
    •Changes in calcium levels in the blood
    •Low thyroid hormone levels (hypothyroidism)
    •Swelling from fluids
    •Worsening of other medical conditions

  • Prices with our coupons for Premarin Vaginal Cream vs. Evamist

    Learn more about Premarin vaginal cream
    Learn more about Evamist

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