Key takeaways
Premarin vaginal cream (conjugated estrogens) and Femring (estradiol acetate) vaginal ring are both estrogen replacement therapies used to treat symptoms of menopause, but they have some key differences. Premarin vaginal cream is applied directly into the vagina and is primarily used to treat vaginal dryness and pain during sex. It can be messy to apply and is applied in cycles or twice a week. On the other hand, Femring is a vaginal ring that treats vaginal dryness and helps with hot flashes and night sweats. You only need to insert Femring once every three months, making it more convenient. However, Femring is absorbed into your bloodstream, which can raise your risk of certain cancers, blood clots, and strokes. Both medications are brand-name only, but Femring might be more expensive. While both treatments have similar risks, Femring offers broader symptom relief compared to Premarin vaginal cream.
