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Compare Endometrin vs. Provera

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Endometrin (progesterone) and Provera (medroxyprogesterone) are both used to address hormone-related issues, but they have different uses and forms. Endometrin is a vaginal insert or suppository used primarily in fertility treatments to help prepare the uterus for pregnancy, while Provera is an oral tablet used to regulate menstrual cycles and protect the uterus from damage in postmenopausal women taking estrogen replacement therapy. Endometrin must be used 2 to 3 times a day and can be expensive since it is only available as a brand medication. In contrast, Provera is taken once a day for a specific number of days each month and is available in a generic form. Endometrin can cause vaginal irritation and requires careful insertion, whereas Provera can cause side effects like spotting, breast tenderness, and nausea. Additionally, Provera has serious risks when taken with estrogen, such as increased risk of certain cancers, which are not associated with Endometrin.

  • Endometrin (progesterone)
    Medroxyprogesterone (Provera)
  • Endometrin (progesterone)
    Medroxyprogesterone (Provera)

  • Summary of Endometrin vs. Provera

    Summary for Progesterone
    Prescription only

    Endometrin (progesterone) is a vaginal insert, or a vaginal suppository, that's used during fertility treatment for people who have trouble becoming pregnant. It's a progesterone that helps ready the uterus for embryo transfer and pregnancy. When you start and stop the medication depends on your fertility treatment and your situation. In general, Endometrin (progesterone) is inserted into the vagina 2 or 3 times a day, unless your prescriber advises you to take it a different way. Side effects include pelvic pain, stomach pain, and nausea.

    Summary for Progestin
    Prescription only

    Medroxyprogesterone (Provera) can help make your menstrual cycles more regular. It also helps protect the uterus from harm in people who've gone through menopause and are taking estrogen replacement medications. When taken with estrogen therapy, it has some serious risks that you should consider if you need treatment for a long time.

  • Indications of Endometrin vs. Provera

    Indications for
    •Infertility
    Indications for
    •Lack of menstrual periods due to hormone imbalance
    •Irregular periods due to hormone imbalance
    •Protection of the uterus in postmenopausal women who are taking estrogen medications

  • Pros and Cons of Endometrin vs. Provera

    Pros and Const for Progesterone
    Pros
    •Might help raise your chances of getting pregnant as part of your fertility treatment plan
    •Might be less painful than progesterone injections
    •Can insert the medication in any position and doesn't require you to lie down after you insert it
    Cons
    •Inserted into the vagina 2 or 3 times a day
    •Inserting the applicator into the vagina can be uncomfortable
    •Only available as a brand-name medication; no lower-cost generic available
    Pros and Const for Progestin
    Pros
    •Taken once a day
    •Helps protect the uterus from damage if taking estrogen medications after menopause
    •A good alternative to progesterone (Prometrium) if you have a peanut allergy
    Cons
    •Need to remember to take on certain days of the month
    •Can have spotting or breakthrough bleeding, even if you've gone through menopause
    •Shouldn't be used in people with liver problems

  • Common Side Effects of Endometrin vs. Provera

    Common Side Effects for
    •Pain after egg retrieval (e.g., pelvic pain, stomach cramps; 25-28%)
    •Stomach pain (12%)
    •Nausea (7-8%)
    •Ovarian hyperstimulation syndrome (swollen ovaries; 7%)
    Common Side Effects for
    •Spotting or breakthrough bleeding
    •Heavier or lighter periods
    •Breast tenderness
    •Nausea

  • Warnings of Endometrin vs. Provera

    Common Side Effects for
    •Blood clots and potential complications, like heart attack or stroke
    •Worsening depression
    •Don't use other vaginal products
    Common Side Effects for
    •When taken with estrogen medications:
    •Blood clots and their complications (heart attack, stroke)
    •Breast cancer
    •Dementia
    •Uterine and ovarian cancer
    •Vision problems
    •Higher blood pressure and cholesterol levels
    •Swelling (fluid buildup)

  • Prices with our coupons for Endometrin vs. Provera

    Learn more about Endometrin
    Learn more about Medroxyprogesterone

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