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Compare Endometrin vs. Prometrium

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Endometrin (progesterone) and Prometrium (progesterone) are both used to address hormone-related issues, but they have different applications and forms. Endometrin is a vaginal insert or suppository primarily used in fertility treatments to prepare the uterus for pregnancy. It must be inserted 2 to 3 times a day and is only available as a brand medication, which can be expensive. On the other hand, Prometrium is available as an oral capsule and an injection, and it helps regulate menstrual cycles, manage abnormal uterine bleeding, and protect the uterus from damage in postmenopausal women using estrogen replacement therapy. Prometrium capsules are taken once a day, often at bedtime, and are available in a lower-cost generic form. However, Prometrium capsules contain peanut oil, making them unsuitable for those with peanut allergies. Both medications can cause side effects like stomach bloating, but Prometrium is more likely to cause dizziness and drowsiness. Serious risks of both these medications include blood clots, strokes, and heart attacks.

  • Endometrin (progesterone)
    Progesterone (Prometrium)
  • Endometrin (progesterone)
    Progesterone (Prometrium)

  • Summary of Endometrin vs. Prometrium

    Summary for Progesterone
    Prescription only

    Endometrin (progesterone) is a vaginal insert, or a vaginal suppository, that's used during fertility treatment for people who have trouble becoming pregnant. It's a progesterone that helps ready the uterus for embryo transfer and pregnancy. When you start and stop the medication depends on your fertility treatment and your situation. In general, Endometrin (progesterone) is inserted into the vagina 2 or 3 times a day, unless your prescriber advises you to take it a different way. Side effects include pelvic pain, stomach pain, and nausea.

    Summary for Progesterone
    Prescription only

    Progesterone (Prometrium) is an oral medication used to protect the uterus in postmenopausal women (those who've gone through menopause) who are also taking estrogen. It can also help regulate menstrual cycles in people who aren't getting their period. The medication is typically taken by mouth once at bedtime for 10-12 days, depending on what you're taking it for. Potential side effects include headache, weight gain or weight loss, and breast tenderness.

  • Indications of Endometrin vs. Prometrium

    Indications for
    •Infertility
    Indications for
    •Protection of the uterus for postmenopausal women also taking estrogen medications
    •Lack of menstrual periods due to hormone imbalance

  • Pros and Cons of Endometrin vs. Prometrium

    Pros and Const for Progesterone
    Pros
    •Might help raise your chances of getting pregnant as part of your fertility treatment plan
    •Might be less painful than progesterone injections
    •Can insert the medication in any position and doesn't require you to lie down after you insert it
    Cons
    •Inserted into the vagina 2 or 3 times a day
    •Inserting the applicator into the vagina can be uncomfortable
    •Only available as a brand-name medication; no lower-cost generic available
    Pros and Const for Progesterone
    Pros
    •Helps protect the uterus and regulate periods
    •Taken by mouth once a day
    •Might be easier to take than the injection form
    Cons
    •Not a good option for people with liver problems
    •Shouldn't be used in people with a peanut allergy
    •Potentially raises your risk of serious blood clots

  • Common Side Effects of Endometrin vs. Prometrium

    Common Side Effects for
    •Pain after egg retrieval (e.g., pelvic pain, stomach cramps; 25-28%)
    •Stomach pain (12%)
    •Nausea (7-8%)
    •Ovarian hyperstimulation syndrome (swollen ovaries; 7%)
    Common Side Effects for
    •Headache (31%)
    •Breast tenderness (27%)
    •Joint pain (20%)
    •Depression (19%)
    •Dizziness (15%)
    •Stomach bloating (12%)
    •Hot flashes (11%)
    •Trouble urinating (11%)
    •Stomach pain (10%)
    •Vaginal discharge (10%)

  • Warnings of Endometrin vs. Prometrium

    Common Side Effects for
    •Blood clots and potential complications, like heart attack or stroke
    •Worsening depression
    •Don't use other vaginal products
    Common Side Effects for
    •Blood clots
    •Breast cancer
    •Dementia
    •Vision problems
    •Dizziness and drowsiness
    •Fluid buildup

  • Prices with our coupons for Endometrin vs. Prometrium

    Learn more about Endometrin
    Learn more about Progesterone

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