provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Progesterone Coupon - Progesterone 100mg capsule

progesterone

Generic Prometrium
Used for Endometriosis, Irregular Menstruation
Used for Endometriosis, Irregular Menstruation

Progesterone (Prometrium) is an oral medication used to protect the uterus in postmenopausal women (those who've gone through menopause) who are also taking estrogen. It can also help regulate menstrual cycles in people who aren't getting their period. The medication is typically taken by mouth once at bedtime for 10-12 days, depending on what you're taking it for. Potential side effects include headache, weight gain or weight loss, and breast tenderness.

Last reviewed on October 16, 2024
basics-icon

What is Progesterone (Prometrium)?

What is Progesterone (Prometrium) used for?

How Progesterone (Prometrium) works

Progesterone (Prometrium) is a progestin. It works by protecting the uterus from becoming too thick. It also helps regulate periods by giving the body more progesterone, a hormone that helps control the menstrual cycle. This helps to balance the natural levels of progesterone in the body.

Are you looking for information on progesterone injection, Crinone (progesterone) vaginal gel, or Endometrin (progesterone) vaginal insert instead?

Drug Facts

Common BrandsPrometrium
Drug ClassProgesterone
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$49.190
GoodRx discount
$49.19
See prices
basics-icon

What are the side effects of Progesterone (Prometrium)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (31%)
  • Breast tenderness (27%)
  • Joint pain (20%)
  • Depression (19%)
  • Dizziness (15%)
  • Stomach bloating (12%)
  • Hot flashes (11%)
  • Trouble urinating (11%)
  • Stomach pain (10%)
  • Vaginal discharge (10%)

Other Side Effects

  • Nausea
  • Vomiting
  • Worry
  • Chest pain
  • Diarrhea
  • Night sweats
  • Breast pain
  • Swelling in the hands or feet
  • Vaginal dryness
  • Constipation

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reactions: trouble breathing, hives, rash, itchiness, swelling of your face, lips, tongue, or throat
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw, sweating, trouble breathing
  • Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face, severe headache
  • Blood clot in the lungs: shortness of breath, chest pain, cough
  • Blood clot in the eyes: sudden vision loss, blurry vision, changes in vision, migraine
  • Liver problems: nausea, yellowing of the skin or whites of the eyes, stomach pain
  • Breast lumps: breast pain or soreness, swelling, rash
  • Unusual vaginal bleeding: abnormal spotting or bleeding

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain

chills

cold or flu-like symptoms

cough or hoarseness

fever

problems with urination

Less common

Clear or bloody discharge from the nipple

dimpling of the breast skin

inverted nipple

lump in the breast or under the arm

persistent crusting or scaling of the nipple

redness or swelling of the breast

sore on the skin of the breast that does not heal

Incidence not known

Abdominal or stomach pain

bloating

blurred vision

change in vaginal discharge

clay-colored stools

cleft lip or palate

confusion

constipation

darkened urine

diarrhea

difficult or labored breathing

difficulty with swallowing

difficulty with walking

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fainting

fast, pounding, or irregular heartbeat or pulse

headache

hives

indigestion

irregular heartbeat

irritation

itching

joint pain, stiffness, or swelling

lightheadedness

loss of appetite

nausea

nervousness

noisy breathing

numbness or tingling in the face, arms, or legs

pain or feeling of pressure in the pelvis

pains in the stomach, side, or abdomen, possibly radiating to the back

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash

redness of the skin

shortness of breath

slow heartbeat

spontaneous abortion

stomach or pelvic discomfort, aching, or heaviness

sweating

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

trouble speaking, thinking, or walking

unpleasant breath odor

unusual tiredness or weakness

vaginal bleeding

vomiting

vomiting of blood

wheezing

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Breast pain or tenderness

depression

muscle or joint pain

white or brownish vaginal discharge

worry

Incidence not known

Attack, assault, or force

blurred or loss of vision

change in walking and balance

changes in behavior

changes in patterns and rhythms of speech

choking

clumsiness or unsteadiness

confusion about identity, place, and time

continuing ringing or buzzing or other unexplained noise in the ears

decreased awareness or responsiveness

difficulty with moving

disturbed color perception

double vision

drowsiness

extreme dizziness or drowsiness

feeling drunk

feeling of constant movement of self or surroundings

feeling of unreality

hair loss or thinning of the hair

halos around lights

hearing loss

hives or welts

longer or heavier menstrual periods

loss of consciousness

muscle cramps

muscle stiffness

night blindness

normal menstrual bleeding occurring earlier, possibly lasting longer than expected

overbright appearance of lights

redness of the skin

relaxed and calm

sensation of spinning

sense of detachment from self or body

severe sleepiness

sleepiness

slurred speech

swollen tongue

thoughts of killing oneself

tunnel vision

weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Progesterone (Prometrium)

thumbs-up

Pros

Helps protect the uterus and regulate periods

Taken by mouth once a day

Might be easier to take than the injection form

thumbs-down

Cons

Not a good option for people with liver problems

Shouldn't be used in people with a peanut allergy

Potentially raises your risk of serious blood clots

pharmacist-tips

Pharmacist tips for Progesterone (Prometrium)

pharmacist
  • Take progesterone (Prometrium) at bedtime since it can make you feel tired or dizzy. Don't drive or perform dangerous activities without seeing how it affects you.

    • If you're having trouble swallowing progesterone (Prometrium) capsules, stand upright and take them with a glass of water to help get the capsule down to your stomach faster.

      • Progesterone (Prometrium) contains peanut oil, so tell your prescriber if you're allergic to peanuts. Speak with your care team about all of your allergies so they can make sure this medication is safe for you.

        • If you're taking progesterone (Prometrium) to regulate your period, your period should start within 7 days after the last capsule. If your period doesn't start by this point, let your prescriber know. If you've been sexually active, you should also take a pregnancy test.

          • Let your prescriber know if you experience unusual or heavy vaginal bleeding, lumps in your breast, changes to your vision, or severe headaches after starting progesterone (Prometrium). These are not typical side effects and could be a sign of more serious problems.

            • Since progesterone (Prometrium) raises your risk for serious blood clots and certain cancers, speak regularly with your prescriber about if you should continue taking this medication.

              faqs

              Frequently asked questions about Progesterone (Prometrium)

              Does progesterone (Prometrium) cause weight gain?
              The effects of progesterone (Prometrium) on weight aren't clear. Some people taking this medication have reported weight gain, while others have reported weight loss. Your weight might change because progesterone (Prometrium) can cause your body to hold on to more water. If you notice any changes in your weight, talk to your prescriber about possible causes.
              Why take progesterone (Prometrium) at night?
              Progesterone (Prometrium) should be taken at bedtime because some people get drowsy or dizzy after taking this medication. It can also cause blurry vision and trouble walking. Taking it at bedtime will help you sleep off some of these side effects. If they become too bothersome, let your prescriber know.
              Does progesterone (Prometrium) make you tired?
              It can. Some people reported feeling very drowsy during clinical studies after taking progesterone (Prometrium). If you feel very tired during the day, contact your prescriber.
              How do you reduce side effects of progesterone (Prometrium)?
              To lower your risk of dizziness and sleepiness, take your dose of progesterone (Prometrium) at bedtime. If you experience headache, cramping, or breast tenderness, consider taking an over-the-counter pain reliever until your symptoms get better. Report any side effects to your care team so they can help you manage them.
              How long does progesterone (Prometrium) stay in your system?
              It takes about 3-4 days for progesterone (Prometrium) to leave your system. This is based on the medication's half-life, which is a measure of how long it takes for half of the medication to leave your body.
              Is progesterone (Prometrium) micronized progesterone?
              Yes, progesterone (Prometrium) contains micronized progesterone. This means the progesterone has been reduced to small particles, which makes it easier for your body to absorb the medication from your gut.
              Is progesterone (Prometrium) synthetic?
              Yes, progesterone (Prometrium) is a synthetic form of progesterone. It's made in a lab from plant sources, but is made to be chemically identical to progesterone that's naturally made in your body. Progesterone (Prometrium) is considered a bioidentical hormone.
              Is progesterone (Prometrium) used in in vitro fertilization?
              While progesterone is sometimes used off-label in in vitro fertilization (IVF), the oral capsule form isn't commonly used. This is because the way it's broken down in your body is different from the vaginal or injectable forms and there isn't as much experience with it. Speak with your reproductive endocrinologist if you have questions about the type of progesterone that's right for you.
              GoodRxEducationalIcon

              How to save using GoodRx

              Compare Prices
              1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
              Select your free coupon
              2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
              Show coupon to your pharmacist
              3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
              Get free couponLearn more
              warings-icon

              What are the risks and warnings for Progesterone (Prometrium)?

              Progesterone (Prometrium) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Blood clots

              • Risk factors: Taking progesterone (Prometrium) with estrogens | Personal or family history of blood clots | High blood pressure | Diabetes | High cholesterol | Smoking | Obesity | Systemic lupus erythematosus (SLE)

                Progesterone (Prometrium) can raise your risk of blood clots, especially when taken with estrogen medications. This can be very dangerous and lead to heart attack, stroke, or pulmonary embolism (life-threatening blood clot in the lungs). Be sure to discuss all your medical conditions with your prescriber before starting progesterone (Prometrium). Call 911 or seek immediate medical attention if you have pain in your legs or arms, chest pain, sudden severe headaches, trouble breathing, or sudden changes in your speech.

                risk-warning

                Breast cancer

                • Risk factors: Personal or family history of breast cancer | Long-term use of estrogen and progesterone (Prometrium) together

                  There's a higher risk of developing breast cancer when taking progesterone (Prometrium) and estrogen medications together. The longer you take this combination, the higher your risk is. That's why it's best to use progesterone (Prometrium) only for the shortest amount of time needed. Follow up with your prescriber regularly so they can make sure you still need to take this medication.

                  risk-warning

                  Dementia

                  • Risk factors: Age 65 or older | Taking progesterone (Prometrium) with estrogens

                    People taking progesterone (Prometrium) and estrogen medications together might have a higher risk of developing dementia. While experts aren't sure why this happens, your risk is highest if you start using this combination for the first time at the age of 65 or older. If you or your loved one notices that you're becoming forgetful, confused, anxious, or are having a hard time making decisions or solving problems, let your prescriber know.

                    risk-warning

                    Vision problems

                    Progesterone (Prometrium) can cause retinal thrombosis, or a blood clot in the eyes. Speak to your prescriber right away if you notice changes in your vision, sudden vision loss, bulging eyes, double vision, or migraine.

                    risk-warning

                    Dizziness and drowsiness

                    Progesterone (Prometrium) capsules can cause you to feel dizzy or sleepy. This is temporary but can affect your concentration and focus. It's best to take progesterone (Prometrium) right before you go to bed, so that you're less likely to feel this way during the day. Don't drive or perform dangerous activities until you feel better.

                    risk-warning

                    Fluid buildup

                    • Risk factors: Heart failure | Kidney problems

                      Progesterone (Prometrium) can cause extra fluid to build up in your body, especially in your legs, ankles, and feet. This is more likely to happen if you have certain conditions like kidney problems or heart failure. The extra fluid can cause these other conditions to get worse. If you know you have problems with fluid buildup or swelling, tell your prescriber before you start using progesterone (Prometrium). Call your prescriber or seek medical help right away if you notice unexplainable swelling, unexplained weight gain, or sudden trouble breathing.

                      dosage

                      Progesterone (Prometrium) dosage forms

                      The average cost for 30 capsules of 100mg of Progesterone (Prometrium) is $412.90 with a free GoodRx coupon. This is 7.89% off the average retail price of $448.28.
                      capsule
                      Capsule
                      DosageQuantityPrice as low asPrice per unit
                      100mg30 capsules$412.90$13.76
                      200mg30 capsules$773.05$25.77

                      Typical dosing for Progesterone (Prometrium)

                      • Uterus protection: The typical dose is 200 mg by mouth once a day at bedtime for 12 days in a row. Repeat these directions every 28 days.

                      • Lack of menstrual periods: The typical dose is 400 mg by mouth once a day at bedtime for 10 days. You should expect a period within 7 days of your last capsule.

                      interactions

                      Interactions between Progesterone (Prometrium) and other drugs

                      Progesterone (Prometrium) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Progesterone (Prometrium). Please note that only the generic name of each medication is listed below.

                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      drug-cost

                      How much does Progesterone (Prometrium) cost?

                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                      contraindications-icon

                      Progesterone (Prometrium) contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Progesterone (Prometrium) will not be safe for you to take.
                      • Allergy to peanuts

                      • Undiagnosed abnormal vaginal bleeding

                      • Breast cancer

                      • Blood clotting problems

                      • Liver problems

                      • Currently pregnant

                      alternatives

                      What are alternatives to Progesterone (Prometrium)?

                      There are a number of medications that your doctor can prescribe in place of Progesterone (Prometrium). Compare a few possible alternatives below.
                      Progesterone (Prometrium)
                      Used for:
                      $49.19 Lowest GoodRx priceView Prices
                      Used for:
                      • Lack of menstrual periods due to hormone imbalance

                      • Irregular periods due to hormone imbalance

                      • Protection of the uterus in postmenopausal women who are taking estrogen medications

                      $6.58 Lowest GoodRx priceView Prices
                      Used for:
                      $14.10 Lowest GoodRx priceView Prices
                      latest news

                      What is the latest news about Progesterone (Prometrium)?

                      images

                      Progesterone (Prometrium) images

                      White Oval Pr1 - Progesterone 100mg Capsule
                      This medicine is White, Oval Capsule Imprinted With "Pr1".White Oval Pr1 - Progesterone 100mg Capsule
                      Pink Round Ak - Progesterone 100mg Capsule
                      This medicine is Pink, Round Capsule Imprinted With "Ak".Pink Round Ak - Progesterone 100mg Capsule
                      Peach Round P1 - Progesterone 100mg Capsule
                      This medicine is Peach, Round Capsule Imprinted With "P1".Peach Round P1 - Progesterone 100mg Capsule
                      Orange Round A87 - Progesterone 100mg Capsule
                      This medicine is Orange, Round Capsule Imprinted With "A87".Orange Round A87 - Progesterone 100mg Capsule
                      White Oval Pr1 - Progesterone 100mg Capsule
                      This medicine is White, Oval Capsule Imprinted With "Pr1".White Oval Pr1 - Progesterone 100mg Capsule

                      Get savings updates for Progesterone (Prometrium)

                      Receive price alerts, news, and other messages from GoodRx about Progesterone (Prometrium) and other healthcare topics and relevant savings offers.

                      By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.

                      References

                      Best studies we found

                      Acertis Pharmaceuticals, LLC. (2024). Prometrium- progesterone capsule [package insert]. DailyMed.

                      American College of Obstetricians and Gynecologists. (2024). Endometrial hyperplasia.

                      Fitzpatrick, L. A., et al. (1999). Micronized progesterone: Clinical indications and comparison with current treatments. Fertility and Sterility.

                      View All References (4)

                      Lord, M., et al. (2024). Secondary amenorrhea. StatPearls.

                      MedlinePlus. (2024). Retinal vein occlusion.

                      Society for Assisted Reproductive Technology. (n.d.). Progesterone.

                      You and Your Hormones. (2021). Progesterone.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                      Was this page helpful?

                      Browse medications

                      View All

                      Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.