Endometrin vs. Crinone: 5 Things to Consider When Comparing These Vaginal Progesterones
Endometrin and Crinone are two forms of vaginal progesterone used during fertility treatments. Learn more about their benefits and differences with this guide.
progesterone
Used for Fertility
Used for Fertility
Endometrin (progesterone) is a vaginal insert, or a vaginal suppository, that's used during fertility treatment for people who have trouble becoming pregnant. It's a progesterone that helps ready the uterus for embryo transfer and pregnancy. When you start and stop the medication depends on your fertility treatment and your situation. In general, Endometrin (progesterone) is inserted into the vagina 2 or 3 times a day, unless your prescriber advises you to take it a different way. Side effects include pelvic pain, stomach pain, and nausea.
What is Endometrin (progesterone)?
What is Endometrin (progesterone) used for?
How Endometrin (progesterone) works
Endometrin (progesterone) contains progesterone, an essential hormone for pregnancy. Progesterone prepares the uterus to receive and nourish an embryo.
Drug facts
| Common Brands | Endometrin |
|---|---|
| Drug Class | Progesterone |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
More on Endometrin (progesterone) essentials
Side effects of Endometrin (progesterone)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Pain after egg retrieval (e.g., pelvic pain, stomach cramps; 25-28%)
- Stomach pain (12%)
- Nausea (7-8%)
- Ovarian hyperstimulation syndrome (swollen ovaries; 7%)
Less Common Side Effects
- Stomach bloating
- Vomiting
- Constipation
- Fatigue
- Headache
- Vaginal irritation
- Vaginal burning
- Vaginal discharge
Endometrin (progesterone) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Blood clot(s): pain in the lower leg that won't go away, sudden shortness of breath, coughing up blood, sudden blindness
- Heart attack: chest pain or tightness; pain that travels to your shoulder, arm, neck, or jaw
- Stroke: sudden trouble talking or walking; numbness on one side of your body or face; sudden, severe headaches
- Abnormal vaginal bleeding
The following Endometrin (progesterone) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Clear or bloody discharge from the nipple
dimpling of the breast skin
inverted nipple
lump in the breast or under the arm
persistent crusting or scaling of the nipple
redness or swelling of the breast
sore on the skin of the breast that does not heal
Incidence not known
Abdominal or stomach pain
blurred vision
change in vaginal discharge
clay-colored stools
cleft lip or palate
confusion
darkened urine
difficult or labored breathing
difficulty with swallowing
difficulty with walking
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
fast, pounding, or irregular heartbeat or pulse
headache
indigestion
irregular heartbeat
irritation
joint pain, stiffness, or swelling
lightheadedness
loss of appetite
nervousness
noisy breathing
numbness or tingling in the face, arms, or legs
pain or feeling of pressure in the pelvis
pains in the stomach, side, or abdomen, possibly radiating to the back
pounding in the ears
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
redness of the skin
shortness of breath
slow heartbeat
spontaneous abortion
stomach or pelvic discomfort, aching, or heaviness
sweating
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
trouble speaking, thinking, or walking
unpleasant breath odor
unusual tiredness or weakness
vaginal bleeding
vomiting
vomiting of blood
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Attack, assault, or force
blurred or loss of vision
change in walking and balance
changes in behavior
changes in patterns and rhythms of speech
choking
clumsiness or unsteadiness
confusion about identity, place, and time
continuing ringing or buzzing or other unexplained noise in the ears
decreased awareness or responsiveness
difficulty with moving
disturbed color perception
double vision
drowsiness
extreme dizziness or drowsiness
feeling drunk
feeling of constant movement of self or surroundings
feeling of unreality
hair loss or thinning of the hair
halos around lights
hearing loss
hives or welts
longer or heavier menstrual periods
loss of consciousness
muscle cramps
muscle stiffness
night blindness
normal menstrual bleeding occurring earlier, possibly lasting longer than expected
overbright appearance of lights
redness of the skin
relaxed and calm
sensation of spinning
sense of detachment from self or body
severe sleepiness
sleepiness
slurred speech
swollen tongue
thoughts of killing oneself
tunnel vision
weight changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$404.65
GoodRx discount
$62.25
Pros and cons of Endometrin (progesterone)
Pros
- Might help raise your chances of getting pregnant as part of your fertility treatment plan
- Might be less painful than progesterone injections
- Can insert the medication in any position and doesn't require you to lie down after you insert it
Cons
- Inserted into the vagina 2 or 3 times a day
- Inserting the applicator into the vagina can be uncomfortable
- Only available as a brand-name medication; no lower-cost generic available
Pharmacist tips for Endometrin (progesterone)
- It's important that you take Endometrin (progesterone) exactly as instructed and for as long as instructed. Carefully following your fertility specialist's directions can help raise your chances of getting and staying pregnant. Don't stop using this medication earlier than instructed.
- It's best to spread out your Endometrin (progesterone) doses evenly throughout the day, unless your fertility specialist instructs you to take the medication at certain times of the day. For example, you could insert the medication when you wake up, around lunch time, and in the evening if you're taking it three times a day.
- Some people might have extra vaginal discharge while they're taking Endometrin (progesterone). You might want to wear a panty liner to prevent the discharge from getting onto your underwear.
- While weight gain isn't a typical side effect of Endometrin (progesterone), stomach bloating can be. For some, stomach bloating might make pants or other clothes feel tighter, as if you've gained weight. The bloating is temporary and should go away once you've finished taking the medication. Let your fertility specialist know if you're worried about the bloating is worrisome or if it doesn't go away.
- Tell your fertility specialist right away if you have any irregular vaginal bleeding after you start using Endometrin (progesterone). This can be a sign of a possible miscarriage.
- Don't use any other vaginal products when you're using Endometrin (progesterone). They can affect how well the medication works.
How to insert Endometrin (progesterone)
- Wash your hands before you insert Endometrin (progesterone) into your vagina.
- Find a position that's comfortable for you to insert Endometrin (progesterone) into your vagina. You can insert it while you're standing, sitting, or lying on your back with your knees bent. You don't have to keep lying down after you insert the medication.
- Unwrap the applicator, and place 1 insert (the tablet) into the space at the end of the applicator.
- Gently insert the applicator as far as you comfortably can into your vagina, similarly to how you would insert a tampon. Once it's inside your vagina, press the plunger down to release the insert.
- Gently pull out the applicator from your vagina. Throw the applicator away into the trash after each use and wash your hands.
Risks and warnings for Endometrin (progesterone)
Endometrin (progesterone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Blood clots and potential complications, like heart attack or stroke
Before you start Endometrin (progesterone), tell your prescriber about your full medical history, especially any blood clots. You won't be able to take this medication if you've had a blood clot before.
Be aware of the following signs and symptoms of a blood clot. Blood clots can sometimes lead to serious problems like heart attack or stroke.
- Clot in the leg (deep vein thrombosis, DVT): swelling, tenderness, or pain in the leg
- Clot in the lung (pulmonary embolism, PE): shortness of breath
- Clot in the eye: partial or complete vision loss
- Heart attack: chest pain, arm pain, shortness of breath, a cold sweat, lightheadedness
- Stroke: sudden weakness on one side of your body, drooping face, trouble breathing, bad headaches, trouble speaking or walking
Call 911 or seek immediate medical attention if you have any signs or symptoms of a blood clot, heart attack, or stroke.
Worsening depression
- Risk factors: History of depression
It's possible for Endometrin (progesterone) to worsen depression if you already have or have had depression. Let your prescriber know right away if you notice any changes in your mood or if you have any worsening feelings of hopelessness, fear, or despair.
Don't use other vaginal products
It's not recommended to use any other vaginal products while you're using Endometrin (progesterone). Using other products that are inserted into the vagina, such as creams or medications to treat a yeast infection, can change the way your body absorbs Endometrin (progesterone). This can make Endometrin (progesterone) work less well. Speak with a healthcare professional about other options while you're using Endometrin (progesterone) if you're interested in using a vaginal product or if you have a vaginal infection.
Endometrin (progesterone) dosage
The average cost for 21 inserts of 100mg of Endometrin (progesterone) is $62.25 with a free GoodRx coupon. This is 84.62% off the average retail price of $404.65. 
Insert
Insert| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 100mg | 21 inserts | $62.25 | $2.96 |
Typical dosage for Endometrin (progesterone)
Each vaginal insert contains 100 mg of progesterone.
The usual dose is 1 insert placed into your vagina 2 to 3 times a day. You'll typically start Endometrin (progesterone) after your egg retrieval and continue the medication for up to a total of 10 weeks.
Be sure to follow your fertility specialist's instructions because how and when you take Endometrin (progesterone) can be different depending on your fertility treatment.
Interactions between Endometrin (progesterone) and other drugs
Endometrin (progesterone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Endometrin (progesterone). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Conivaptan
- Eslicarbazepine Acetate
- Fosnetupitant
- Netupitant
How much does Endometrin (progesterone) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Endometrin (progesterone) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Endometrin (progesterone) will not be safe for you to take.
- Abnormal vaginal bleeding that hasn't been examined by a healthcare professional
- Known missed abortion or ectopic pregnancy
- Liver problems
- Known or possible breast cancer or genital cancer
- Currently have or have had a blood clot
- Allergy to other progesterone products
What are alternatives to Endometrin (progesterone)?
There are a number of medications that your doctor can prescribe in place of Endometrin (progesterone). Compare a few possible alternatives below.
News about Endometrin (progesterone)
How Much Do In Vitro Fertilization (IVF) Medications Cost?
Costs of IVF vary widely depending on factors like clinic location, treatment protocols, and individual health needs.
Your GoodRx Guide to IVF Medications: How They Work, When They’re Used, and Ways to Save
Each medication used in an IVF cycle has a specific role to play. Learn the ins and outs of fertility medications with GoodRx.
What’s the Role of Progesterone in Pregnancy and Infertility Treatment?
Progesterone is a natural hormone that helps support a healthy pregnancy. Learn how progesterone works and the role it plays in infertility treatment.
Endometrin (progesterone) images
