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Endometrin Coupon - Endometrin 100mg insert

Endometrin

progesterone
Used for Fertility
Used for Fertility

Endometrin (progesterone) is a vaginal insert, or a vaginal suppository, that's used during fertility treatment for people who have trouble becoming pregnant. It's a progesterone that helps ready the uterus for embryo transfer and pregnancy. When you start and stop the medication depends on your fertility treatment and your situation. In general, Endometrin (progesterone) is inserted into the vagina 2 or 3 times a day, unless your prescriber advises you to take it a different way. Side effects include pelvic pain, stomach pain, and nausea.

Last reviewed on July 24, 2024
basics-icon

What is Endometrin (progesterone)?

What is Endometrin (progesterone) used for?

How Endometrin (progesterone) works

Endometrin (progesterone) contains progesterone, an essential hormone for pregnancy. Progesterone prepares the uterus to receive and nourish an embryo.

Drug Facts

Common BrandsEndometrin
Drug ClassProgesterone
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Endometrin (progesterone) essentials

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$372.53(save 15.41%)
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$315.14
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What are the side effects of Endometrin (progesterone)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Stomach bloating
  • Vomiting
  • Constipation
  • Fatigue
  • Headache
  • Vaginal irritation
  • Vaginal burning
  • Vaginal discharge

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Blood clot(s): pain in the lower leg that won't go away, sudden shortness of breath, coughing up blood, sudden blindness
  • Heart attack: chest pain or tightness; pain that travels to your shoulder, arm, neck, or jaw
  • Stroke: sudden trouble talking or walking; numbness on one side of your body or face; sudden, severe headaches
  • Abnormal vaginal bleeding

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Signs of toxic shock syndrome—for cervical caps or diaphragms

Chills

confusion

dizziness

fever

lightheadedness

muscle aches

sunburn-like skin rash that is followed by peeling of the skin

unusual redness of the inside of the nose, mouth, throat, vagina, or eyelids

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

For females and males

Skin rash, redness, irritation, or itching that does not go away within a short period of time

For females only

Cloudy or bloody urine

increased frequency of urination

pain in the bladder or lower abdomen

thick, white, or curd-like vaginal discharge—with use of cervical caps or diaphragms only

vaginal irritation, redness, rash, dryness, or whitish discharge

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Vaginal discharge (temporary)—with use of creams, foams, and suppositories

vaginal dryness or odor

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Endometrin (progesterone)

thumbs-up

Pros

Might help raise your chances of getting pregnant as part of your fertility treatment plan

Can insert the medication in any position and doesn't require you to lie down after you insert it

thumbs-down

Cons

Inserted into the vagina 2 or 3 times a day

Inserting the applicator into the vagina can be uncomfortable

Only available as a brand-name medication; no lower-cost generic available

pharmacist-tips

Pharmacist tips for Endometrin (progesterone)

pharmacist
  • It's important that you take Endometrin (progesterone) exactly as instructed and for as long as instructed. Carefully following your fertility specialist's directions can help raise your chances of getting and staying pregnant. Don't stop using this medication earlier than instructed.

    • It's best to spread out your Endometrin (progesterone) doses evenly throughout the day, unless your fertility specialist instructs you to take the medication at certain times of the day. For example, you could insert the medication when you wake up, around lunch time, and in the evening if you're taking it three times a day.

      • Some people might have extra vaginal discharge while they're taking Endometrin (progesterone). You might want to wear a panty liner to prevent the discharge from getting onto your underwear.

        • While weight gain isn't a typical side effect of Endometrin (progesterone), stomach bloating can be. For some, stomach bloating might make pants or other clothes feel tighter, as if you've gained weight. The bloating is temporary and should go away once you've finished taking the medication. Let your fertility specialist know if you're worried about the bloating is worrisome or if it doesn't go away.

          • Tell your fertility specialist right away if you have any irregular vaginal bleeding after you start using Endometrin (progesterone). This can be a sign of a possible miscarriage.

            • Don't use any other vaginal products when you're using Endometrin (progesterone). They can affect how well the medication works.

              • Wash your hands before you insert Endometrin (progesterone) into your vagina.

                • Find a position that's comfortable for you to insert Endometrin (progesterone) into your vagina. You can insert it while you're standing, sitting, or lying on your back with your knees bent. You don't have to keep lying down after you insert the medication.

                  • Unwrap the applicator, and place 1 insert (the tablet) into the space at the end of the applicator.

                    • Gently insert the applicator as far as you comfortably can into your vagina, similarly to how you would insert a tampon. Once it's inside your vagina, press the plunger down to release the insert.

                      • Gently pull out the applicator from your vagina. Throw the applicator away into the trash after each use and wash your hands.

                        faqs

                        Frequently asked questions about Endometrin (progesterone)

                        How do you insert Endometrin (progesterone) vaginally?
                        Unwrap the applicator, and place 1 insert (the tablet) into the space on the thin end of the applicator. Gently insert the applicator as far as you comfortably can into your vagina (similar to inserting a tampon). Then, press the plunger to release the medication. Throw the applicator away after each use.
                        How far do you insert Endometrin (progesterone) into the vagina?
                        Insert the Endometrin (progesterone) vaginal insert as far as it will comfortably go. It's inserted into the vagina like a tampon. Ask your fertility specialist if you have questions about inserting Endometrin (progesterone) into the vagina.
                        Can Endometrin (progesterone) cause spotting?
                        It's possible that you can have some vaginal bleeding or spotting with Endometrin (progesterone). It's important to report any irregular or concerning vaginal bleeding to your fertility specialist or healthcare professional (HCP). They can examine you to see whether there's something serious going on.
                        Does Endometrin (progesterone) make you tired?
                        Fatigue or tiredness is a possible side effect of Endometrin (progesterone). Avoid driving or performing activities that require you to be alert until you know how this medication affects you.
                        Does Endometrin (progesterone) need to be refrigerated?
                        No, it's best to store Endometrin (progesterone) at room temperature. It's generally okay if Endometrin (progesterone) gets a little colder or warmer than room temperature. But the medication might get damaged it it gets colder than 59 degrees Fahrenheit, if it becomes frozen, or if it's left out at very hot temperatures (above 86 degrees Fahrenheit).
                        How long do you have to lie down for after you use Endometrin (progesterone)?
                        You don't necessarily have to lie down after you insert Endometrin (progesterone) into your vagina. The medication should fit snugly in the vagina after you insert it. The medication shouldn't fall out, so you can move or walk around right after you insert it into the vagina.
                        Why do I have to use Endometrin (progesterone) for 10 weeks?
                        It takes about 10 weeks after an embryo has implanted for the placenta to start nourishing your baby. Until that time, the hormone progesterone helps your body support the pregnancy. Using Endometrin (progesterone) for 10 weeks gives your body extra progesterone until the placenta takes over and makes progesterone during the rest of the pregnancy. Your fertility specialist might instruct you to take Endometrin (progesterone) for a different amount of time, depending on your situation. So be sure to follow your fertility specialist's instructions on how long to take the medication.
                        What's the difference between Crinone and Endometrin?
                        Both Endometrin and Crinone are forms of progesterone that are inserted into the vagina and helps promote a healthy pregnancy during fertility treatment. But there are many differences between the two. Endometrin is a vaginal tablet (suppository), whereas Crinone is a vaginal gel. Endometrin is generally inserted two or three times a day, whereas Crinone is inserted just one or two times a day. Speak with your healthcare team if you're not sure which progesterone product is best for you on your fertility journey.
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                        What are the risks and warnings for Endometrin (progesterone)?

                        Endometrin (progesterone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Blood clots and potential complications, like heart attack or stroke

                        Before you start Endometrin (progesterone), tell your prescriber about your full medical history, especially any blood clots. You won't be able to take this medication if you've had a blood clot before.

                        Be aware of the following signs and symptoms of a blood clot. Blood clots can sometimes lead to serious problems like heart attack or stroke.

                        • Clot in the leg (deep vein thrombosis, DVT): swelling, tenderness, or pain in the leg

                          • Clot in the lung (pulmonary embolism, PE): shortness of breath

                            • Clot in the eye: partial or complete vision loss

                              • Heart attack: chest pain, arm pain, shortness of breath, a cold sweat, lightheadedness

                                • Stroke: sudden weakness on one side of your body, drooping face, trouble breathing, bad headaches, trouble speaking or walking

                                  Call 911 or seek immediate medical attention if you have any signs or symptoms of a blood clot, heart attack, or stroke.

                                  risk-warning

                                  Worsening depression

                                  • Risk factors: History of depression

                                    It's possible for Endometrin (progesterone) to worsen depression if you already have or have had depression. Let your prescriber know right away if you notice any changes in your mood or if you have any worsening feelings of hopelessness, fear, or despair.

                                    risk-warning

                                    Don't use other vaginal products

                                    It's not recommended to use any other vaginal products while you're using Endometrin (progesterone). Using other products that are inserted into the vagina, such as creams or medications to treat a yeast infection, can change the way your body absorbs Endometrin (progesterone). This can make Endometrin (progesterone) work less well. Speak with a healthcare professional about other options while you're using Endometrin (progesterone) if you're interested in using a vaginal product or if you have a vaginal infection.

                                    dosage

                                    Endometrin (progesterone) dosage forms

                                    The average cost for 21 inserts of 100mg of Endometrin (progesterone) is $315.14 with a free GoodRx coupon. This is 15.41% off the average retail price of $372.53.
                                    insert
                                    Insert
                                    DosageQuantityPrice as low asPrice per unit
                                    100mg21 inserts$315.14$15.01

                                    Typical dosing for Endometrin (progesterone)

                                    Each vaginal insert contains 100 mg of progesterone.

                                    The usual dose is 1 insert placed into your vagina 2 to 3 times a day. You'll typically start Endometrin (progesterone) after your egg retrieval and continue the medication for up to a total of 10 weeks.

                                    Be sure to follow your fertility specialist's instructions because how and when you take Endometrin (progesterone) can be different depending on your fertility treatment.

                                    interactions

                                    Interactions between Endometrin (progesterone) and other drugs

                                    Endometrin (progesterone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Endometrin (progesterone). Please note that only the generic name of each medication is listed below.

                                    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

                                    Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

                                    Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                                    contraindications-icon

                                    Endometrin (progesterone) contraindications

                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Endometrin (progesterone) will not be safe for you to take.
                                    • Abnormal vaginal bleeding that hasn't been examined by a healthcare professional

                                    • Known missed abortion or ectopic pregnancy

                                    • Liver problems

                                    • Known or possible breast cancer or genital cancer

                                    • Currently have or have had a blood clot

                                    • Allergy to other progesterone products

                                    alternatives

                                    What are alternatives to Endometrin (progesterone)?

                                    There are a number of medications that your doctor can prescribe in place of Endometrin (progesterone). Compare a few possible alternatives below.
                                    Endometrin (progesterone)
                                    Used for:
                                    $315.14 Lowest GoodRx priceView Prices
                                    Used for:
                                    $458.42 Lowest GoodRx priceView Prices
                                    images

                                    Endometrin (progesterone) images

                                    White Oblong Fpi And 100 - Endometrin 100mg Vaginal Insert
                                    This medicine is White, Oblong Insert Imprinted With "100" And "Fpi".White Oblong Fpi And 100 - Endometrin 100mg Vaginal Insert
                                    White Oblong Fpi And 100 - Endometrin 100mg Vaginal Insert
                                    This medicine is White, Oblong Insert Imprinted With "100" And "Fpi".White Oblong Fpi And 100 - Endometrin 100mg Vaginal Insert

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                                    References

                                    Best studies we found

                                    Cable, J. K., et al. (2023). Physiology, progesterone. StatPearls.

                                    Ferring Pharmaceuticals. (2019). Endometrin® administration guide.

                                    Ferring Pharmaceuticals. (2021). How to use Endometrin® (progesterone) vaginal insert 100 mg.

                                    View All References (3)

                                    Ferring Pharmaceuticals Inc. (2022). Endometrin- progesterone insert [package insert]. DailyMed.

                                    Kumar, P., et al. (2011). Ovarian hyperstimulation syndrome. Journal of Human Reproductive Sciences.

                                    World Health Organization. (n.d.). Clinical services Recommendation 31: Medical management of missed abortion at gestational ages < 14 weeks (3.4.3).

                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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