Key takeaways
Prempro (conjugated estrogens/medroxyprogesterone) and Provera (medroxyprogesterone) are both used to manage symptoms related to menopause and hormone imbalances, but they have some key differences. Prempro is a combination of estrogen and progestin, while Provera only contains medroxyprogesterone, a type of progestin. Prempro is used to relieve menopausal symptoms like hot flashes and vaginal dryness, and it also helps prevent bone loss. Provera, on the other hand, is primarily used to regulate menstrual periods and protect the uterus in postmenopausal women taking estrogen. Prempro is taken once daily, whereas Provera's dosing can vary depending on the condition being treated. Prempro is only available as a brand-name medication, while Provera has a generic form, which can be more affordable. Both medications carry serious risks, especially when used long-term, including an increased risk of certain cancers, blood clots, and strokes.
