provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
HomeDrugsImvexxy

Imvexxy Dosages: Your GoodRx Guide

Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMPAmy B. Gragnolati, PharmD, BCPS
Published on June 14, 2024

Key takeaways:

  • Imvexxy (estradiol vaginal insert) is a prescription product that can relieve bothersome symptoms of menopause such as painful intercourse.

  • The typical Imvexxy dosage starts at 4 mcg inserted into the vagina once per day. After 2 weeks, Imvexxy can be used twice per week (every 3 to 4 days).

  • There are ways to save on Imvexxy. GoodRx can help you access Imvexxy at an exclusive cash price of $85. A manufacturer savings card is also available.

Access savings on related medications

In the center of a peach background with graph paper texture and representational step graph is a black and white cutout of a hand holding a vaginal suppository pill.
GoodRx Health

Vaginal dryness is a common menopause symptom. It happens when your natural estrogen levels fall during this time. But it can be uncomfortable. And for many women, it can make sex painful.

If painful sex due to menopause is happening to you, Imvexxy (estradiol vaginal insert) is a prescription medication to consider. It’s a small, teardrop-shaped capsule that’s inserted into your vagina to provide relief just where you need it. The estrogen in Imvexxy can help make sex less painful.

If you’re just starting Imvexxy, we’ve laid out what you need to know about the manufacturer’s recommended Imvexxy dosage, as well as details on how to use Imvexxy.

Promotion disclosure
Manufacturer exclusive discount
Avg retail price
$257.08(Save 66.94%)
GoodRx discount
$85.00
How it works
drug-savings-illustration-1Use GoodRx to find medications, pharmacies, and discounts.
drug-savings-illustration-2GoodRx discounts can help you pay less for your prescription.
drug-savings-illustration-3Bring your free coupon or savings card to the pharmacy.

What’s the typical Imvexxy dosage?

The typical Imvexxy dosage is to place one capsule in the vagina once a day, about the same time each day, for 2 weeks. After 2 weeks, you should place one capsule in the vagina twice a week. There should be about 3 or 4 days between each dose. You should plan to use Imvexxy on the same two days of the week, such as Monday and Thursday of each week.

Imvexxy is available in two doses: 4 mcg and 10 mcg. It’s recommended to start with the 4 mcg dose. If the 4 mcg dose isn’t working well enough, your prescriber can raise your dosage to 10 mcg.

Good to know: Long-term use of estrogen products for menopause symptoms isn’t right for everyone. It’s a good idea to ask your prescriber at follow-up appointments if you should continue using Imvexxy. Depending on your age and symptoms, they may suggest trying to come off it.

GoodRx icon
  • About pain during sex: Menopause is one of several causes of pain during sex. Read about the other common causes of painful sex and how you can help relieve it.

  • Comparing options: Imvexxy is one of several vaginal estrogen products. Read more about the different vaginal estrogen products used for menopause symptoms.

  • Better sex after menopause: Menopause means the end to menstruation — not the end of your sex life. Read here for tips on enhancing your sex life and achieving better orgasms after menopause.

How to use Imvexxy

It can be tricky to use Imvexxy when you first get started with it. But with time and practice, you should find that the process gets easier.

Below are seven steps that explain how to use Imvexxy:

  1. Wash your hands with soap and water before inserting Imvexxy. Make sure they’re completely dry before handling the capsule.

  2. Push one Imvexxy capsule out of its blister pack.

  3. Hold Imvexxy between your fingers with the small, tapered end facing upwards.

  4. Pick a position that’s comfortable for you to insert Imvexxy. Many people prefer to lie on their back with their knees bent. Others prefer to stand with one leg placed on a small step stool.

  5. With the small end still facing up, use your fingers to insert Imvexxy about 2 inches into the vagina. For most people, 2 inches is about where the second knuckle of your index or middle finger is. Do not place Imvexxy in your mouth or swallow it.

  6. Remove your finger from your vagina, leaving Imvexxy in place.

  7. Wash your hands with soap and water after finishing.

Good to know: You don’t need to lie down after placing Imvexxy. The capsule is designed to stay in place, even if you’re standing and moving around. If you notice Imvexxy comes back out, try placing it a little further inside the vagina. If you’ve tried this and it still comes back out, contact your prescriber. They can help you figure out why this is happening.

What happens if you miss a dose of Imvexxy?

If you miss a dose of Imvexxy and you’re using it daily, insert it as soon as you remember. But if it’s close to time for your next dose, skip it. Just use your next dose of Imvexxy at its normal time. Keep in mind that you should only use one capsule in a single day.

If you miss a dose and you’re using Imvexxy twice a week, it’s a good idea to give your prescriber or pharmacist a call. Directions for correcting missed doses vary depending on how long it's been since you missed it. Remember, you shouldn’t use Imvexxy more often than once every 3 to 4 days. A healthcare professional can help you get back on schedule safely.

How to save on Imvexxy

There are ways to save on Imvexxy, which is available as a brand-name medication. GoodRx can help you navigate between GoodRx coupons and copay savings cards to save money on your prescription.

  • Save with GoodRx: Anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase 8 inserts of Imvexxy at an exclusive cash price of $85.

  • Save with a copay savings card: If you have commercial insurance, you may be eligible to pay as little as $35 for Imvexxy using a savings card from the manufacturer.

The bottom line

Imvexxy is an estradiol vaginal insert (capsule). The typical Imvexxy dosage is to place one capsule in the vagina once a day for the first 2 weeks. After that, you’ll typically insert Imvexxy twice a week. Twice-weekly doses should be separated by about 3 or 4 days. It’s recommended that most people start with the 4 mcg capsules. If you need greater symptom relief, your prescriber may increase your Imvexxy dosage to 10 mcg.

why trust our exports reliability shield

Why trust our experts?

Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP
Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP, has over a decade of experience as a pharmacist, professor, and researcher. She was a full-time clinical professor in the pharmacy practice department at D’Youville School of Pharmacy before subsequently joining the faculty of the pharmacy practice department at the University at Buffalo School of Pharmacy and Pharmaceutical Sciences.
Christina Aungst, PharmD
Christina Aungst, PharmD, is a pharmacy editor for GoodRx. She began writing for GoodRx Health in 2019, transitioning from freelance writer to editor in 2021.
Amy B. Gragnolati, PharmD, BCPS
Amy Gragnolati, PharmD, BCPS, is a pharmacy editor for GoodRx. Amy currently holds her pharmacist license in Georgia and California.

References

Mayne Pharma LLC. (2024). Imvexxy [package insert].

MedlinePlus. (2022). Estrogen vaginal.

View All References (1)
GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

Was this page helpful?

Subscribe and save.

Get prescription saving tips and more from GoodRx Health. Enter your email to sign up.

By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.