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Duavee Coupon - Duavee 0.45mg/20mg tablet

Duavee

conjugated estrogens and bazedoxifene
Used for Osteoporosis, Menopause
Used for Osteoporosis, Menopause

Duavee (conjugated estrogens / bazedoxifene) treats vasomotor symptoms of menopause like hot flashes and night sweats. It can also help prevent osteoporosis in people who've gone through menopause. This combination medication has two active ingredients. The estrogen helps restore estrogen levels in the body while the selective estrogen receptor modulator (SERM) helps protect against bone loss. The dosage is 1 tablet taken by mouth once every day. Side effects can include muscle spasms, nausea, and diarrhea.

Last reviewed on January 31, 2025
basics-icon

What is Duavee (conjugated estrogens / bazedoxifene)?

What is Duavee (conjugated estrogens / bazedoxifene) used for?

How Duavee (conjugated estrogens / bazedoxifene) works

Duavee (conjugated estrogens / bazedoxifene) is a combination of two active ingredients.

  • Conjugated estrogens is a mixture of estrogens that works as an estrogen replacement. It helps replace the natural estrogen that your body loses during menopause. This helps treat menopause symptoms, like hot flashes and night sweats.

  • Bazedoxifene is a selective estrogen receptor modulator (SERM). Its effects on estrogen receptors depend on where it works in the body. In bone, bazedoxifene acts like estrogen to prevent bone loss and improve bone mineral density (BMD), a measure of how strong your bones are. In the uterus, bazedoxifene stops estrogen from causing the uterine lining from growing too thick. This helps lower the risk of uterine cancer.

By working together, conjugated estrogens and bazedoxifene help relieve menopause symptoms and prevent osteoporosis while lowering the risk of uterine cancer.

Drug Facts

Common BrandsDuavee
Drug ClassEstrogen replacement / SERM
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Duavee (conjugated estrogens / bazedoxifene)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Muscle spasms or twitching (9%)
  • Nausea (8%)
  • Diarrhea (8%)
  • Indigestion (7%)
  • Upper stomach pain (7%)
  • Throat pain (7%)
  • Dizziness (5%)
  • Neck pain (5%)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Blood clot in leg: leg pain or swelling, skin that's warm to the touch
  • Blood clot in lungs: trouble breathing, chest pain
  • Blood clot near the heart (heart attack): chest pain that travels to the arm, neck, or jaw; shortness of breath; cold sweat
  • Blood clot in the brain (stroke): sudden weakness on one side of the body, bad headache, changes in speech or vision, drooping face, confusion
  • Unusual vaginal bleeding

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Acid or sour stomach

anxiety

backache

belching

bloating

change in vaginal discharge

chest pain

chills

clear or bloody discharge from the nipple

confusion

constipation

cough

darkened urine

difficulty with speaking

dimpling of the breast skin

dizziness or lightheadedness

double vision

fainting

fast heartbeat

fever

full or bloated feeling or pressure in the stomach

headache

heartburn

inability to move the arms, legs, or facial muscles

inability to speak

indigestion

inverted nipple

loss of appetite

lump in the breast or under the arm

nausea

pain or feeling of pressure in the pelvis

pain, redness, or swelling in the arm or leg

pains in the stomach, side, or abdomen, possibly radiating to the back

persistent crusting or scaling of the nipple

redness or swelling of the breast

slow speech

sore on the skin of the breast that does not heal

stomach discomfort, upset, or pain

sudden shortness of breath or troubled breathing

swelling of the abdominal or stomach area

vaginal bleeding

vomiting

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

muscle spasm

throat pain

upper abdominal or stomach pain

Less common

Neck pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Duavee (conjugated estrogens / bazedoxifene)

thumbs-up

Pros

Relieves bothersome menopause symptoms, such as hot flashes and night sweats

Contains an ingredient (bazedoxifene) that helps lower the risk for uterine cancer (no need to take an additional progestin medication)

thumbs-down

Cons

Not a first-choice option for preventing osteoporosis in people who've gone through menopause

Not recommended for people who haven't gone through menopause, people 75 years or older, or people with kidney problems

pharmacist-tips

Pharmacist tips for Duavee (conjugated estrogens / bazedoxifene)

pharmacist
  • Duavee (conjugated estrogens / bazedoxifene) comes in blister cards that are sealed with a foil covering to help protect the medication from moisture. Keep the tablets in the blister cards. Don't use a pill organizer to store the medication.

    • Use 1 blister card at a time. Also take out 1 tablet at a time from the blister card when you're ready to take Duavee (conjugated estrogens / bazedoxifene).

      • Write the date on the provided line on the Duavee (conjugated estrogens / bazedoxifene) blister card when you take out the first tablet in the card. Don't take any of the tablets in the blister card if more than 60 days have passed since this written date.

        • You can take Duavee (conjugated estrogens / bazedoxifene) with or without food. Taking it with food can help prevent stomach upset, which is a possible side effect of the medication.

          • Tell your prescriber at least 4 to 6 weeks before any planned surgeries, bedrest, or other situations where you won't be moving much. They'll tell you when you should stop taking Duavee (conjugated estrogens / bazedoxifene) before and when to restart it afterwards. This helps lower your risk for blood clots.

            • If you're taking Duavee (conjugated estrogens / bazedoxifene) for osteoporosis, speak with your prescriber about taking calcium and vitamin D supplements to help keep your bones strong. They can also recommend other ways to strengthen your bones, such as adding some weight-bearing exercises to your routine.

              • Don't take any progestins, other estrogens, or other selective estrogen receptor modulators (SERMs) while you're taking Duavee (conjugated estrogens / bazedoxifene). It can raise your risk for certain side effects.

                faqs

                Frequently asked questions about Duavee (conjugated estrogens / bazedoxifene)

                Is there a generic for Duavee (conjugated estrogens / bazedoxifene)?
                No. There isn't a generic available for Duavee (conjugated estrogens / bazedoxifene). It's currently available as a brand-name medication only. Speak with your prescriber if you're looking for a generic option.
                Does Duavee (conjugated estrogens / bazedoxifene) cause weight gain?
                Weight gain wasn't a side effect of Duavee (conjugated estrogens / bazedoxifene) that people reported during clinical studies. Keep in mind that fluid retention is a possible side effect of the medication. And this can sometimes appear as water weight. Also note that weight gain is common during menopause because of hormonal changes in the body, among other things. Duavee (conjugated estrogens / bazedoxifene) is approved for use for people who are in this stage in life, so some of the weight gain you might have might be related to menopause. Speak with your primary care provider if you're concerned about your weight while you're taking Duavee (conjugated estrogens / bazedoxifene).
                Does Duavee (conjugated estrogens / bazedoxifene) cause hair loss?
                People who took Duavee (conjugated estrogens / bazedoxifene) didn't report hair loss during clinical studies. Talk with your prescriber if you notice hair loss or hair thinning while you're taking this medication. They can try to figure out what might be causing this.
                How long does Duavee (conjugated estrogens / bazedoxifene) take to work?
                In a clinical study, some people who took Duavee (conjugated estrogens / bazedoxifene) had an improvement in their menopause symptoms within about 4 weeks of treatment. Some had fewer hot flashes each day and these hot flashes felt less intense. But it could take several months of treatment before you get the most benefit from the medication. Keep in mind that everybody can have a different experience with the medication. Speak with your prescriber if you're concerned about how long it's taking for Duavee (conjugated estrogens / bazedoxifene) to work for you.
                What's the difference between Duavee (conjugated estrogens / bazedoxifene) and estradiol?
                Duavee (conjugated estrogens / bazedoxifene) and estradiol are both hormonal replacement therapy (HRT). They're both used to treat menopause symptoms and prevent bone loss during menopause. A key difference is that Duavee contains bazedoxifene along with an estrogen. Bazedoxifene helps prevent the uterus lining from growing too thick due to estrogen. But estradiol is estrogen only. So people with a uterus usually need a separate progestin to lower the risk of uterine cancer. Also, Duavee only comes as a tablet. But estradiol is available in many different forms like tablets and patches. Estradiol also comes as vaginal creams and inserts for vaginal menopause symptoms only. Talk to your prescriber to compare between Duavee and estradiol.
                What's the difference between Duavee and Bijuva?
                Duavee (conjugated estrogens / bazedoxifene) and Bijuva (estradiol / progesterone) are both types of hormonal replacement therapy (HRT) that are taken once daily. They both help treat vasomotor symptoms of menopause, including hot flashes and night sweats. But Duavee is also approved to prevent osteoporosis during menopause. You can take Duavee at any time of day as long as it's consistent. It also doesn't matter if you take the medication with or without food. On the other hand, it's recommended that you take Bijuva in the evening with food. Speak with your prescriber to learn more about the differences between Duavee and Bijuva.
                Is Duavee (conjugated estrogens / bazedoxifene) made from horse urine?
                The conjugated estrogens component of Duavee is a mixture of purified, natural estrogens taken from the urine of pregnant horses. Speak with your prescriber if this is a concern for you. They can talk to you about other options that aren't made from an animal source to help relieve menopause symptoms or prevent osteoporosis.
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                What are the risks and warnings for Duavee (conjugated estrogens / bazedoxifene)?

                Duavee (conjugated estrogens / bazedoxifene) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Risk for blood clots and related complications (e.g., heart attack, stroke)

                • Risk factors: Personal or family history of blood clots | High blood pressure | Diabetes (high blood sugar) | Smoking | High cholesterol | People who are considered obese | Lupus | Taking additional estrogen medications

                  The active ingredients in Duavee (conjugated estrogens / bazedoxifene) can raise the risk of developing blood clots. These clots can block blood flow to other parts of the body, like the leg, lungs, heart, or brain. Some clots can lead to dangerous complications, such as heart attack or stroke.

                  Before you start taking Duavee (conjugated estrogens / bazedoxifene), speak with your prescriber about whether the medication is safe for you. There are many things that can raise your risk for blood clots, such as having high blood pressure, smoking, and long periods of time when you're not moving as much. Don't take Duavee (conjugated estrogens / bazedoxifene) to prevent heart disease.

                  Be sure you know the signs and symptoms of a blood clot, heart attack, and stroke.

                  • Blood clot in arm or leg: swelling, pain, or tenderness in the arm or leg; skin that's warm to the touch

                    • Blood clot in the lung: chest pain, trouble breathing

                      • Heart attack (blood clot near the heart): chest pain traveling to the arm, neck, or jaw; shortness of breath; cold sweat; lightheadedness

                        • Stroke (blood clot in the brain): sudden weakness on one side of the body, drooping face, bad headache, changes in speech or vision, confusion

                          Stop taking Duavee (conjugated estrogens / bazedoxifene) and get medical help as soon as possible if you have any signs or symptoms of a blood clot.

                          risk-warning

                          Risk for uterine cancer (also called endometrial cancer)

                          • Risk factors: Estrogen therapy without additional progestin | People with a healthy uterus | Taking estrogen therapy for more than 1 year | Taking additional estrogen medications

                            Duavee contains conjugated estrogens and bazedoxifene. Estrogens can thicken and change the lining of your uterus called the endometrium. It can sometimes lead to uncontrolled growth of the uterine lining and put people with a healthy uterus at risk for uterine cancer (or endometrial cancer). Bazedoxifene helps balance out estrogen's effect on the uterine lining, which helps lower the risk for cancer.

                            Even though Duavee (conjugated estrogens / bazedoxifene) contains an ingredient that helps protect against the potential effects of estrogen on the uterine lining, it's important to be aware of this risk. Know the warning signs of uterine cancer, such as vaginal bleeding that doesn't go away or keeps coming back or pelvic pain. Speak with your prescriber if you're concerned about the risk for uterine cancer. Let your prescriber know if you notice any unusual vaginal bleeding.

                            risk-warning

                            Unknown risk for breast cancer or ovarian cancer

                            It isn't clear whether Duavee (conjugated estrogens / bazedoxifene) raises the risk for breast cancer or ovarian cancer. To be safe, it's important to continue to get screened for these cancers while you're taking this medication.

                            Get breast scans (mammograms) at the recommended times and do self-exams to check for any lumps or unusual changes. Talk to your primary care provider or gynecologist if you notice any unusual vaginal bleeding; vaginal discharge; pelvic pain; or unusual changes in breast shape, size, or color. They can examine you to see what's going on.

                            risk-warning

                            Risk for dementia

                            • Risk factors: Age 65 years or older

                              Studies suggest that people age 65 years and older who've gone through menopause and are taking estrogen-only therapy might be at greater risk for dementia. Make sure you're aware of possible early signs of dementia, like memory loss, confusion about time, getting lost, and misplacing things often. Speak with your primary care provider if you're worried about the risk for dementia. Don't take Duavee (conjugated estrogens / bazedoxifene) to prevent dementia.

                              risk-warning

                              Gallbladder or liver problems in certain people

                              • Risk factors: History of liver problems or jaundice

                                The risk for gallbladder problems is higher for people who've gone through menopause and are taking estrogen medications like Duavee (conjugated estrogens / bazedoxifene). Tell your prescriber if you've previously had jaundice (yellow of the skin or whites of the eyes). And let your care team know if you start noticing jaundice or stomach pain that doesn't go away after you start taking Duavee (conjugated estrogens / bazedoxifene). These can be signs of gallbladder or liver problems. Don't take this medication if you have liver problems.

                                risk-warning

                                Changes in vision

                                Although very rare, some people who took estrogens have had changes in their vision due to a clot that formed in the blood vessels of the eye. Stop taking Duavee (conjugated estrogens / bazedoxifene) right away and let your primary care provider know if you have sudden partial or complete vision loss, bulging eyes, double vision, or migraines.

                                risk-warning

                                High triglyceride (fat) levels

                                • Risk factors: History of having high triglyceride levels in the blood

                                  Estrogen therapy might make the triglyceride (fat) levels in your blood to go up. Too much triglyceride in your blood can lead swelling in the pancreas (pancreatitis). The risk for pancreatitis might be higher for people who already have high triglyceride levels. Contact your primary care provider right away if you notice symptoms of pancreatitis, like stomach pain that spreads to your back, stomach tenderness, nausea, vomiting, or fever.

                                  risk-warning

                                  Low thyroid hormone levels in people who take thyroid hormone replacement therapy

                                  • Risk factors: Low thyroid hormone levels (hypothyroidism)

                                    Estrogens can cause changes in thyroid hormone levels in your body. Normally, your body can adjust to these changes by itself. But it might be harder for your body to adjust if you already have low thyroid hormone levels (hypothyroidism).

                                    To help adjust to changes in thyroid hormone levels during treatment, you might need to take a higher dose of your thyroid hormone replacement medication for your thyroid condition while you're taking Duavee (conjugated estrogens / bazedoxifene). Continue to get blood tests done when instructed by your primary care provider to check your thyroid hormone levels.

                                    risk-warning

                                    Buildup of fluids in the body (fluid retention)

                                    • Risk factors: Heart failure | Kidney problems

                                      It's possible for medications containing estrogens like Duavee (conjugated estrogens / bazedoxifene) to make your body hold onto extra fluid. Signs of fluid retention can include swelling of your hands, feet, or ankles.

                                      Tell your primary care provider if you have heart failure because you're at higher risk for fluid retention. In addition, fluid retention can worsen this medical condition. Duavee (conjugated estrogens / bazedoxifene) isn't recommended for people with kidney problems (they're also at risk for complications from fluid retention).

                                      Call your primary care provider if you notice swelling or signs that your heart condition is worsening while you're taking Duavee (conjugated estrogens / bazedoxifene).

                                      risk-warning

                                      Worsening of other medical conditions

                                      Let your prescriber know about your full medical history before you start taking Duavee (conjugated estrogens / bazedoxifene). It's possible for this medication to worsen symptoms of other medical conditions. Examples include asthma, diabetes, epilepsy, migraine, and lupus. It can also include hypoparathyroidism and hereditary angioedema (a condition that causes serious swelling).

                                      dosage

                                      Duavee (conjugated estrogens / bazedoxifene) dosage forms

                                      The average cost for 30 tablets of 0.45mg/20mg of Duavee (conjugated estrogens / bazedoxifene) is $25.00 with a free GoodRx coupon. This is 90.04% off the average retail price of $250.94.
                                      tablet
                                      Tablet
                                      DosageQuantityPrice as low asPrice per unit
                                      0.45mg/20mg30 tablets$25.00$0.83

                                      Typical dosing for Duavee (conjugated estrogens / bazedoxifene)

                                      Each tablet contains 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene.

                                      The typical dose is 1 tablet by mouth once daily.

                                      interactions

                                      Interactions between Duavee (conjugated estrogens / bazedoxifene) and other drugs

                                      Duavee (conjugated estrogens / bazedoxifene) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Duavee (conjugated estrogens / bazedoxifene). Please note that only the generic name of each medication is listed below.

                                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      drug-cost

                                      How much does Duavee (conjugated estrogens / bazedoxifene) cost?

                                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                                      contraindications-icon

                                      Duavee (conjugated estrogens / bazedoxifene) contraindications

                                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Duavee (conjugated estrogens / bazedoxifene) will not be safe for you to take.
                                      alternatives

                                      What are alternatives to Duavee (conjugated estrogens / bazedoxifene)?

                                      There are a number of medications that your doctor can prescribe in place of Duavee (conjugated estrogens / bazedoxifene). Compare a few possible alternatives below.
                                      Duavee (conjugated estrogens / bazedoxifene)
                                      Used for:
                                      $25.00 Lowest GoodRx priceView Prices
                                      Used for:
                                      $213.30 Lowest GoodRx priceView Prices
                                      Used for:
                                      • Treatment of moderate-to-severe symptoms of menopause (e.g., hot flashes, night sweats) for people with a healthy uterus

                                      • Prevention of osteoporosis for people who've gone through menopause with a healthy uterus

                                      $246.88 Lowest GoodRx priceView Prices
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                                      Duavee (conjugated estrogens / bazedoxifene) images

                                      Pink Oval 0.45 / 20 - Duavee 0.45mg-20mg Tablet
                                      This medicine is Pink, Oval Tablet Imprinted With "0.45/20".Pink Oval 0.45 / 20 - Duavee 0.45mg-20mg Tablet

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                                      References

                                      Best studies we found
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