The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Breast pain (up to 36%)
- Headaches (up to 19%)
- Stomach pain (up to 17%)
- Menstrual cramps (up to 13%)
- Gas (up to 8%)
- Nausea (up to 8%)
- Depression (up to 8%)
- More vaginal discharge than usual (up to 8%)
Less Common Side Effects
- Back pain
- Weakness
- Dizziness
- Migraines
- Itching
- Breast growth
- Vaginal pain
- Weight gain
Prempro serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reactions: swelling of the tongue or throat, trouble breathing, skin rash or hives
- Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
- Stroke: sudden trouble talking or walking, numbness on one side of your body or face, severe headache, dizziness, confusion
- Blood clot: chest pain, shortness of breath, dizziness, fast heart rate, swelling, pain, or redness in the arms or legs
- Cancer: lumps, pain, swelling, or changes in the breasts; swollen lymph nodes, unusual or heavy vaginal bleeding, bloating, extreme tiredness, stomach-area pain
Source: DailyMed
The following Prempro side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine
blurred vision
clear or bloody discharge from the nipple
cough or hoarseness
dimpling of the breast skin
dizziness
fast, irregular, pounding, or racing heartbeat or pulse
feeling faint, dizzy, or lightheaded
feeling of warmth or heat
fever or chills
flushing or redness of the skin, especially on the face and neck
headache
inverted nipple
lower back or side pain
lump in the breast or under the arm
nervousness
pain during sexual intercourse
painful or difficult urination
persistent crusting or scaling of the nipple
pounding in the ears
redness or swelling of the breast
severe cramping of the uterus
sore on the skin of the breast that does not heal
sweating
thick, white vaginal discharge with no odor or with a mild odor
tingling of the hands or feet
unusual weight gain or loss
vaginal bleeding that is unusual and heavy
vaginal or genital itching
vaginal yeast infection
Incidence not known
Absent, missed, or irregular menstrual periods
acid or sour stomach
backache
breast pain or tenderness
confusion
darkened urine
decreased vision or other changes in vision
difficulty with speaking
double vision
fainting
inability to move the arms, legs, or facial muscles
inability to speak
indigestion
loss of appetite
pain or discomfort in the arms, jaw, back, or neck
pain or feeling of pressure in the pelvis
pain, redness, or swelling in the arm or leg
painful or tender cysts in the breasts
pains in the stomach, side, or abdomen, possibly radiating to the back
slow speech
sudden shortness of breath or troubled breathing
unexpected or excess milk flow from the breasts
vomiting
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Blemishes on the skin
body aches or pain
congestion
depersonalization
difficulty with moving
dryness of the vagina
dysphoria
euphoria
excessive muscle tone
feeling paranoid
flu-like symptoms
fullness or swelling of the breasts
hair loss or thinning of the hair
headache, severe and throbbing
leg cramps
loss of bladder control
menstrual periods that are longer or heavier
muscle pain or stiffness
pain in the joints
pain or tenderness around the eyes and cheekbones
quick to react or overreact emotionally
rapidly changing moods
rash
sore mouth or tongue
stuffy or runny nose
tender, swollen glands in the neck
tightness of the chest or wheezing
trouble with sleeping
trouble with swallowing
vaginal discharge that is clear or white
voice changes
white patches in the mouth or on the tongue
Incidence not known
Changes in appetite
hives or welts
inability to have or keep an erection
increased hair growth, especially on the face
increased interest in sexual intercourse
irritability
loss in sexual ability, desire, drive, or performance
loss of scalp hair
pain in the ankles or knees
painful, red lumps under the skin, mostly on the legs
patchy brown or dark brown discoloration of the skin
redness of the skin
weight changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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