Key takeaways:
Prempro (conjugated estrogens / medroxyprogesterone) is a brand-name medication that can help relieve menopause symptoms. Without insurance, the average retail cost of Prempro 0.3 mg / 1.5 mg is $327.03 for a 28-day supply.
Factors such as the dose you’re taking and the pharmacy you use can affect your out-of-pocket costs for Prempro.
There are ways to save on Prempro. GoodRx can help you access Prempro at an exclusive cash price. A manufacturer savings card and patient assistance program are also available.
Save on related medications
Menopause brings many changes with it. It can also bring bothersome symptoms, such as hot flashes and vaginal dryness. Menopausal hormone therapy (MHT) is a common option for managing these symptoms.
Prempro (conjugated estrogens / medroxyprogesterone) is an example of an oral MHT. With just 1 pill a day, it can provide relief from hot flashes, vaginal dryness, and more. If you’re uninsured, you’re likely wondering how much Prempro costs. Below, you’ll find details about the medication’s cost and ways you can save on your prescription.
How much does Prempro cost without insurance?
Without insurance, the average retail cost of Prempro is $327.03 per package (a 28-day supply). This is the price for the 0.3 mg / 1.5 mg starting dose. The medication comes in 4 doses.
The average retail prices of other Prempro doses are:
Which factors affect the cost of Prempro?
Several factors affect the cost of Prempro. Some factors can raise the price, while others may lower it.
Brand vs. generic availability
Generic medications help lower costs without sacrificing quality. So opting for generic versions when they’re available is one of the best ways to save money on prescriptions.
Prempro doesn’t have a generic version available. But if a generic does come to market, costs will likely go down.
Dosage and quantity
Out-of-pocket Prempro prices may vary slightly among doses. For instance, a package of the 0.3 mg / 1.5 mg dose costs about $327.03. A package of the 0.625 mg / 5 mg dose is $314.62.
The number of packages you purchase at a time will also affect your total cost. But as we’ll discuss later, buying in bulk can sometimes lower your monthly costs in the long run.
Location
Your location may also affect the cost of Prempro. For instance, people living in New Orleans tend to pay more overall for prescription medications than people living in Denver.
Pharmacy
Pharmacies may charge different out-of-pocket amounts for prescription medications — even within the same neighborhood. GoodRx can help you compare Prempro cash prices at pharmacies in your area. If one pharmacy offers lower prices than others, you can ask your prescriber to send your prescription there.
Insurance coverage and discounts
Using insurance (if you have it) or applying discounts can help lower the price of Prempro. But keep in mind that insurance copays and coinsurance can change. Your plan could also charge an annual deductible. So the cost of Prempro may be higher until you meet your deductible.
Review your plan’s summary of benefits and coverage and formulary (list of covered medications). This can help you determine if your plan covers Prempro and what you can expect to pay for it. If you’re unsure, you can also call the member services phone number on your prescription insurance card.
What to do if Prempro isn’t covered by your insurance
If your insurance doesn’t cover Prempro, try these options:
Use GoodRx to help lower your costs.
See if you qualify for Prempro’s patient assistance program.
Ask your insurance company to make a formulary exception and cover Prempro. If your request is denied, you have the right to file an appeal to challenge the decision.
During the next open enrollment period, compare plans to see if another one offers better coverage for Prempro.
Ask your prescriber about lower-cost alternatives
Prempro isn’t the only menopause treatment available. Some Prempro alternatives have generic versions, and your insurance may offer better coverage for them. Ask your prescriber if one of these MHTs would be an option for you:
Estradiol / norethindrone (Activella, Mimvey, Lopreeza)
Estradiol / norethindrone (Femhrt, Fyavolv, Jinteli, Jevantique)
Estradiol patches (Climara, Vivelle-dot)
Estradiol tablets
Conjugated estrogen tablets (Premarin)
Good to know: If you have your uterus, it’s recommended to take an estrogen and a progestogen (lab-made progesterone). The progestogen helps protect your uterus against damage that estrogen can cause. Prempro contains both components. If you’re switching to another MHT, you may receive two prescriptions: one for an estrogen and one for a progestogen.
Ways to save on Prempro
Here are five ways you could potentially save on Prempro.
1. Use a GoodRx coupon
A GoodRx coupon could help you save on Prempro without insurance. Anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase Prempro at an exclusive cash price.
Here’s how to get a coupon:
Go to www.goodrx.com or open the GoodRx app on your mobile device.
Type “Prempro” in the search bar.
Click “Start saving,” or tap or click return.
Select the correct dose and quantity, along with your location.
Choose to get your coupon by text or email, or print it out.
If possible, show the coupon at the pharmacy before they start filling your prescription to avoid delays in processing.
Keep in mind: GoodRx savings may vary by pharmacy and the state you live in. The GoodRx website and app can help you compare prices in your area.
2. See if you qualify for a copay savings card
If you have commercial insurance, you may be eligible to save with a manufacturer copay savings card. With this card, you could pay as little as $25 for 28 tablets of Prempro. This program offers a maximum savings of $110 per month and $1,440 per calendar year.
To qualify for the copay savings card, you must:
Have commercial insurance
Not be enrolled in a government-funded insurance plan, such as Medicare or Medicaid
Be at least age 18
Live in the U.S. (including Puerto Rico)
If you’re uninsured, you’re unable to use the Prempro copay savings card. You can sign up for the card online. For questions, call 1-833-966-4584.
3. Check if you’re eligible for a patient assistance program
If you’re uninsured or underinsured, you may be able to access Prempro for free through the manufacturer’s patient assistance program.
To be eligible for the Prempro patient assistance program, you must:
Meet certain financial requirements and be able to submit proof of income
Be uninsured or have government-funded insurance
Have a prescription for Prempro from a U.S.-licensed health professional
Live in the U.S. or a U.S. territory
You can check your eligibility and fill out an application form online. Your prescriber will need to complete parts of the form, so you should also talk to them.
If you have questions about the application or the program, call 1-866-706-2400 for help.
4. Ask about a 3-month supply
Some pharmacies and insurance providers offer a discount when you buy a 3-month supply of medication. This may lower your overall monthly Prempro costs. Plus, it reduces the number of trips you need to make to the pharmacy.
What’s more, insurance providers may charge a lower copay or coinsurance amount if you use a preferred mail-order pharmacy to fill a 3-month supply. Check with your insurance provider to see if this is available for you.
5. Tap into your HSA, FSA, or HRA
Consider using a health savings account (HSA), a flexible spending account (FSA), or a health reimbursement arrangement (HRA) to buy Prempro. These accounts let you use pretax dollars for copays, coinsurances, and other qualified medical expenses. This can help you reduce spending through tax savings.
Just be sure to review your account’s rules regarding expiration dates. FSA dollars typically have an expiration date. But HSA funds roll over and can be saved for later. HRA dollars may or may not expire, depending on your account.
The bottom line
Prempro (conjugated estrogens / medroxyprogesterone) is an oral medication that can help manage menopause symptoms. Without insurance, the average retail price of Prempro 0.3 mg / 1.5 mg is $327.03 per package (a 28-day supply). Prempro is a brand-name medication that doesn’t have a generic version available. Factors such as the dose you take and the pharmacy you use can also affect your cost.
Anyone with a valid prescription, regardless of insurance status, can use GoodRx to buy Prempro at an exclusive cash price. You could also save on your Prempro prescription by using a manufacturer copay savings card or patient assistance program.
Why trust our experts?
References
Pfizer. (n.d.). Menopause hormone therapies (MHT) by Pfizer savings card.
Pfizer. (n.d.). You have options with menopause hormone therapies (MHT) by Pfizer.
Pfizer RxPathways. (n.d.). Financial support: Third-party funding resources.
Pfizer RxPathways. (n.d.). Find a program.
Wyeth Pharmaceuticals. (2026). Premphase- conjugated estrogens and medroxyprogesterone acetate kit. DailyMed.
