ESTRADIOL; NORGESTIMATE reduces the number and severity of hot flashes due to menopause. It may also help relieve the symptoms of menopause, such as vaginal irritation, dryness, or pain during sex. It may also be used to prevent osteoporosis after menopause. It works by increasing levels of the hormones estrogen and progestin in your body. It is a combination of the hormones estrogen and progestin. Get Prefest for as low as $198.49, which is 14% off the average retail price of $231.49 for the most common version, by using a GoodRx coupon.