The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Pain, swelling, and/or redness at the injection site
Breakthrough bleeding or spotting
Changes in menstrual flow
Changes in weight
Swelling
Vaginal discharge
Breast tenderness

Less Common Side Effects

Acne
Depression
Hair loss or hair growth
Trouble sleeping
Sleepiness
Nausea

Progesterone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

Serious allergic reactions: trouble breathing, hives, rash, itchiness, swelling of your face, lips, tongue, or throat
Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw, sweating, trouble breathing
Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face, severe headache
Blood clot in the lungs: shortness of breath, chest pain, cough
Blood clot in the eyes: sudden vision loss, blurry vision, changes in vision, migraine
Pneumonia: fever, trouble breathing, fatigue, night sweats, cough
Liver problems: nausea, yellowing of the skin or whites of the eyes, stomach pain
Breast lumps: breast pain or soreness, swelling, rash
Unusual vaginal bleeding: abnormal spotting or bleeding

Progesterone

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The following Progesterone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain

chills

cold or flu-like symptoms

cough or hoarseness

fever

problems with urination

Less common

Clear or bloody discharge from the nipple

dimpling of the breast skin

inverted nipple

lump in the breast or under the arm

persistent crusting or scaling of the nipple

redness or swelling of the breast

sore on the skin of the breast that does not heal

Incidence not known

Abdominal or stomach pain

bloating

blurred vision

change in vaginal discharge

clay-colored stools

cleft lip or palate

confusion

constipation

darkened urine

diarrhea

difficult or labored breathing

difficulty with swallowing

difficulty with walking

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fainting

fast, pounding, or irregular heartbeat or pulse

headache

hives

indigestion

irregular heartbeat

irritation

itching

joint pain, stiffness, or swelling

lightheadedness

loss of appetite

nausea

nervousness

noisy breathing

numbness or tingling in the face, arms, or legs

pain or feeling of pressure in the pelvis

pains in the stomach, side, or abdomen, possibly radiating to the back

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash

redness of the skin

shortness of breath

slow heartbeat

spontaneous abortion

stomach or pelvic discomfort, aching, or heaviness

sweating

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

trouble speaking, thinking, or walking

unpleasant breath odor

unusual tiredness or weakness

vaginal bleeding

vomiting

vomiting of blood

wheezing

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Breast pain or tenderness

depression

muscle or joint pain

white or brownish vaginal discharge

worry

Incidence not known

Attack, assault, or force

blurred or loss of vision

change in walking and balance

changes in behavior

changes in patterns and rhythms of speech

choking

clumsiness or unsteadiness

confusion about identity, place, and time

continuing ringing or buzzing or other unexplained noise in the ears

decreased awareness or responsiveness

difficulty with moving

disturbed color perception

double vision

drowsiness

extreme dizziness or drowsiness

feeling drunk

feeling of constant movement of self or surroundings

feeling of unreality

hair loss or thinning of the hair

halos around lights

hearing loss

hives or welts

longer or heavier menstrual periods

loss of consciousness

muscle cramps

muscle stiffness

night blindness

normal menstrual bleeding occurring earlier, possibly lasting longer than expected

overbright appearance of lights

redness of the skin

relaxed and calm

sensation of spinning

sense of detachment from self or body

severe sleepiness

sleepiness

slurred speech

swollen tongue

thoughts of killing oneself

tunnel vision

weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Why trust our experts?

Reviewed by:

Kristianne Hannemann, PharmD

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

Reviewed by:

Daisy Chau, PharmD

Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.