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Entresto vs. Ranexa

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Entresto (sacubitril/valsartan) and Ranexa (ranolazine) are both prescription medications, but they treat different conditions and belong to different drug classes. Entresto is an angiotensin receptor-neprilysin inhibitor (ARNI) used to treat heart failure in people aged 1 year and older. It combines two medications, sacubitril and valsartan, to help relax blood vessels and lower blood pressure. Ranexa, on the other hand, is an antianginal medication used to treat chronic chest pain (angina). Its believed to work by changing the flow of electrolytes in the heart to help it work more efficiently, though its exact mechanism isn't fully understood. Entresto is taken twice daily and is not available as a generic, while Ranexa is also taken twice daily but is available in both brand-name and lower-cost generic forms. Entresto can cause side effects like low blood pressure and high potassium levels, whereas Ranexa can cause headache and constipation. Additionally, Ranexa is not recommended for people with serious liver problems.

Entresto

(sacubitril / valsartan)

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Ranolazine

 

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Summary for Entresto

Prescription only

Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

Indications for Entresto

Pros and Cons for Entresto

Pros

  • First-choice treatment for some people with heart failure
  • Can lower the risk of hospital visits related to heart failure in adults
  • Combines two medications into one pill for convenience
  • Available as tablets, oral pellets, or a prepared oral solution

Cons

  • Need to take twice daily
  • Can cause dizziness and low blood pressure
  • Not safe during pregnancy

Common Side Effects for Entresto

Warnings for Entresto

  • Not safe during pregnancy
  • Swelling of face, tongue, or throat (angioedema)
  • Low blood pressure
  • Kidney problems
  • High potassium levels

Summary for Ranexa

Prescription only

Ranolazine is an extended-release medication for adults used to help treat ongoing chest pain (angina). It's often added when other medications don't well enough. Ranolazine is available as generic tablets, though it was once sold under the brand name Ranexa. There's also a sprinkle form called Aspruzyo Sprinkle. You take the dosage by mouth twice a day. Side effects include dizziness, headache, and constipation.

Indications for Ranexa

Pros and Cons for Ranexa

Pros

  • Can help make you less likely to get chest pain from exercise
  • Can take with or without food
  • An option as an add-on when other medications aren't working well to manage chest pain
  • Okay for people with heart failure or diabetes to take

Cons

  • Not for relieving chest pain after it's started
  • Must take twice a day
  • Can interact with some medications, including certain heart and cholesterol medications
  • Not recommended if you have serious liver problems

Common Side Effects for Ranexa

  • Dizziness (6%)
  • Headache (6%)
  • Constipation (5%)
  • Nausea (4%)

Warnings for Ranexa

  • Abnormal heart rhythm
  • Kidney problems
  • Interactions with other medications

Prices with our coupons for Entresto vs. Ranexa

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Sacubitril/Valsartan60 tablets / 24mg/26mg
$39.33$749.07
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Price Card Drug Icon
Ranolazine60 tablets / 500mg
$18.74$303.44
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