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Ebglyss vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lebrikizumab (Ebglyss) and dupilumab (Dupixent) are both injectable medications used to treat moderate-to-severe eczema. Both medications work by blocking proteins that play a role in causing inflammation. However, they have some important differences. Lebrikizumab is specifically approved for eczema in people 12 years and older, whereas dupilumab is approved for a broader range of conditions, including asthma, sinus congestion with nasal polyps, eosinophilic esophagitis, and prurigo nodularis, and can be used in children as young as 6 months for eczema. Lebrikizumab is injected every 4 weeks for maintenance, while dupilumab can be injected every 1 to 4 weeks, depending on the condition. Common side effects of lebrikizumab include pink eye and injection site reactions, whereas dupilumab may cause eye inflammation and joint pain. Both medications require caution with live vaccines due to potential interactions.

Ebglyss

(lebrikizumab)

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Dupixent

(dupilumab)

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Summary for Ebglyss

Prescription only

Ebglyss (lebrikizumab or lebrikizumab-lbkz) is an injectable medication that’s used to treat moderate-to-severe eczema. It’s approved for people 12 years of age and older who weigh at least 88 lbs. This medication is an interleukin-13 antagonist, which works to reduce swelling and discomfort of the skin caused by eczema. Ebglyss (lebrikizumab) is used when topical products aren’t working well enough or when you can’t use them at all. Some people have had side effects like pink eye and pain around the injection site while using Ebglyss (lebrikizumab).

Indications for Ebglyss

Pros and Cons for Ebglyss

Pros

  • Can use with or without topical corticosteroids
  • Approved for eczema in certain children 12 years of age and older who weigh at least 88 pounds
  • Injected once every two or four weeks

Cons

  • Must inject under the skin
  • Can increase the risk of pink eye
  • Can’t get any live vaccines during treatment

Common Side Effects for Ebglyss

  • Pink eye (10%)
  • Injection site reactions (e.g. pain, swelling, redness; 3%)

Warnings for Ebglyss

  • Risk of allergic reaction
  • Risk of pink eye and inflammation of the cornea
  • Use with caution in people with parasitic (worm) infections
  • Risk of infection with live vaccinations

Summary for Dupixent

Prescription only

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

Indications for Dupixent

Pros and Cons for Dupixent

Pros

  • Taken every other week or monthly for most conditions
  • Approved for some children (specific age depends on the condition)
  • Available as prefilled pens (for people ages 2 years and older)
  • Available as prefilled syringes (for people ages 6 months and older)

Cons

  • Given as an injection under the skin
  • Not used for helping with asthma attacks
  • Can cause injection reactions, such as pain, bruising, and swelling
  • Unknown if it's safe or works well while pregnant or breastfeeding

Common Side Effects for Dupixent

  • Injection site reaction (e.g., pain, swelling, bruising; 10%)
  • Eye redness or eye inflammation (10%)
  • Cold sores (4%)

Warnings for Dupixent

  • Allergic reactions
  • Eye inflammation
  • Other inflammation in the body
  • Risk of worsening of breathing problems in people with asthma or COPD
  • Risk of psoriasis
  • Joint pain and psoriatic arthritis
  • Unknown effect in people with parasitic worm infections
  • Interaction with vaccines

Prices with our coupons for Ebglyss vs. Dupixent

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Ebglyss2 cartons / 1 Prefilled Pen of 250mg/2ml
$7,062.25$9,174.79
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Dupixent2 cartons / 2 pens of 300mg/2ml
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