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Cogentin vs. Neurontin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Benztropine (formerly branded as Cogentin) and gabapentin (Neurontin, Gralise, and Horizant) are both prescription medications, but they are used for different conditions and belong to different drug classes. Benztropine is an anticholinergic medication used as an add-on treatment for Parkinson's disease and to manage movement problems caused by antipsychotic medications. In contrast, gabapentin is an antiepileptic medication used to treat certain seizures and nerve pain, such as pain from shingles. Benztropine is available only as a generic medication, while gabapentin is available both as a generic and under the brand names Neurontin, Gralise, and Horizant. Benztropine can cause side effects like dry mouth, fast heartbeat, and memory problems, whereas gabapentin commonly causes dizziness, sleepiness, and poor muscle control. Additionally, gabapentin needs to be taken multiple times a day, while benztropine's dosing can vary from once daily to multiple times a day depending on the condition being treated. Gabapentin also carries a risk of serious side effects like suicidal thoughts and breathing problems, which are not associated with benztropine.

Benztropine

 

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Gabapentin

(Neurontin)

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Summary for Cogentin

Prescription only

Benztropine is an anticholinergic medication used to treat Parkinson's disease and certain movement problems caused by antipsychotic medications. It comes as a tablet that you take by mouth 1 to 4 times a day. Common side effects include dry mouth, blurry vision, and constipation.

Indications for Cogentin

Pros and Cons for Cogentin

Pros

  • Available as an oral tablet (or injection)
  • Helps reduce tremors and stiffness
  • Dose is adjusted based on your symptoms and side effects

Cons

  • Can cause severe dry mouth that can make it difficult to eat and speak
  • Might reduce your ability to sweat and cause overheating
  • Not a good option for young children and older adults

Common Side Effects for Cogentin

  • Dry mouth
  • Nausea and vomiting
  • Constipation
  • Fast heartbeat

Warnings for Cogentin

  • Confusion and mental health effects
  • Slowed gut movement
  • Heatstroke
  • Muscle weakness

Summary for Neurontin

Prescription only

Gabapentin, also known by its brand name Neurontin, is used to treat nerve pain from shingles in adults. This medication can also help treat partial (focal) seizures in adults and children. Gabapentin (Neurontin) comes as pills and a liquid that you take by mouth. The dosage depends on things like what you're treating, how old you are, and how well the medication is working. In general, you take it 3 times a day. Common side effects include making you feel dizzy and sleepy.

Indications for Neurontin

Pros and Cons for Neurontin

Pros

  • An option for relieving nerve pain caused by shingles
  • Can take with other anti-seizure medications for partial-onset seizures in people 3 years and older
  • Available as a tablet, capsule, and liquid for those who have trouble swallowing pills

Cons

  • Usually need to taken three times per day
  • Can cause dizziness and sleepiness
  • Can cause withdrawal symptoms if you stop taking the medication too suddenly or too fast

Common Side Effects for Neurontin

  • Sleepiness (19%)
  • Dizziness (17%)
  • Poor muscle control or clumsiness (13%)
  • Fatigue (11%)

Warnings for Neurontin

  • Severe allergic reactions
  • Sleepiness, dizziness, and trouble concentrating
  • Risk of suicidal thoughts and behavior
  • Higher risk of seizures and other side effects if you stop the medication too suddenly or too fast
  • Dangerously slowed breathing
  • Changes in behavior in children

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