Compare Artane vs. Gocovri

Trihexyphenidyl and Gocovri (amantadine) are both used to treat movement problems in Parkinson's disease (PD), but they work differently and have different dosing schedules. Trihexyphenidyl is an anticholinergic that blocks acetylcholine to help with tremors and movement-related side effects from other medications. It's taken multiple times a day and is available in both tablet and oral liquid forms. Common side effects include dry mouth, blurry vision, and dizziness. On the other hand, Gocovri is an N-methyl-D-aspartate (NMDA) antagonist that helps with uncontrolled movements (dyskinesia) and "off" episodes caused by levodopa-containing medications. It's taken once a day at bedtime and can be sprinkled on food if you have trouble swallowing pills. Common side effects include hallucinations, dizziness, and dry mouth. Gocovri is not safe during pregnancy and can interact with live vaccines, while trihexyphenidyl can cause more side effects in older adults and should be avoided if you have narrow-angle glaucoma.