Key takeaways
Benztropine (Cogentin) and amantadine (Symmetrel) are both medications used to treat movement disorders, including Parkinson's disease and extrapyramidal symptoms (EPS). However, they belong to different medication classes and have important differences. Benztropine is an anticholinergic medication that works by blocking certain chemicals to reduce muscle spasms and tremors. In contrast, amantadine is an NMDA antagonist that raises dopamine levels to help with movement symptoms. Benztropine is available in oral and injectable forms, while amantadine is taken orally, with options for capsules, tablets, or a solution. Benztropine is typically dosed between 0.5 mg to 6 mg daily, whereas amantadine's dosing ranges from 100 mg to 400 mg daily. Common side effects of benztropine include dry mouth and fast heartbeat, while amantadine may cause nausea, dizziness, and trouble sleeping. Benztropine can interact with certain antipsychotics and tricyclic antidepressants, whereas amantadine is not recommended to take with alcohol due to increased dizziness and confusion. Both medications are available as a lower-cost generic.
