Key takeaways
Rytary (carbidopa / levodopa) and Sinemet (carbidopa / levodopa) are both medications used to treat Parkinson's disease (PD) and conditions that cause similar symptoms, like tremors and stiffness. They belong to the same drug class, which combines a dopa decarboxylase inhibitor with dopamine replacement. However, they differ in their formulations and dosing. Rytary is an extended-release capsule taken three times a day, while Sinemet is available in immediate-release tablets, extended-release tablets, and orally disintegrating tablets, typically taken multiple times a day. Rytary does not have a generic version available yet, whereas Sinemet is available in generic forms. Common side effects for both include nausea, dizziness, involuntary movements, and unusual dreams. Both medications can cause sleepiness and should not be taken with certain monoamine oxidase inhibitors (MAOIs) or iron supplements. Rytary can be opened and sprinkled on applesauce if swallowing is difficult, while Sinemet's extended-release tablets should not be crushed or chewed.
