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Compare Mirapex vs. Zelapar

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Pramipexole
    Selegiline
  • Pramipexole
    Selegiline

  • Summary of Mirapex vs. Zelapar

    Summary for Dopamine agonist
    Prescription only

    Pramipexole is used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). The dosage depends on what form you’re taking: the immediate-release tablet is taken 3 times per day and the extended-release tablet is taken once per day. The immediate-release is only available as a lower-cost generic (the brand name Mirapex has been discontinued in the US). The extended-release version of this medication is available as brand (Mirapex ER) and generic. Side effects include nausea, drowsiness, dizziness, and tiredness.

    Summary for MAO-B inhibitor
    Prescription only

    Selegiline helps relieve symptoms of Parkinson's disease in people who have "off" episodes as their carbidopa/levodopa medication starts to wear off. Selegiline is a type of monoamine oxidase inhibitor (MAOI), which is a drug class that has many drug interactions. Generic selegiline tablets and capsules are taken twice per day; the brand name for the pills, Eldepryl, is no longer available. Selegiline also comes as orally disintegrating tablets (ODTs) under the brand name Zelapar that are dissolved on the tongue once per day. Side effects include changes in blood pressure, nausea, and dizziness.

  • Indications of Mirapex vs. Zelapar

    Indications for
    •Parkinson's disease
    •Moderate-to-severe restless legs syndrome - immediate-release tablets only
    Indications for
    •Relief of "off" episodes in people with Parkinson's disease (PD) who are taking a carbidopa/levodopa medication

  • Pros and Cons of Mirapex vs. Zelapar

    Pros and Const for Dopamine agonist
    Pros
    •Works well to control movement problems
    •Available in a lower-cost generic version
    •Extended-release tablet can be taken once daily
    Cons
    •Only available as a tablet
    •Can cause extreme sleepiness
    •Immediate-release tablets need to be taken 3 times per day.
    Pros and Const for MAO-B inhibitor
    Pros
    •Extends the actions of carbidopa/levodopa to relieve PD symptoms
    •Comes as tablets, capsules, and ODTs
    •Taken once or twice a day, depending on the form of the medication
    Cons
    •Doesn't work well when you take it by itself; must take in addition to a carbidopa/levodopa medication
    •Commonly causes nausea and dizziness

  • Common Side Effects of Mirapex vs. Zelapar

    Common Side Effects for

    Early Parkinson’s disease (PD)

    •Sleepiness (33-36%)
    •Nausea (22-24%)
    •Constipation (12-14%)
    •Dizziness (12%)
    •Swelling in arms or legs (5-8%)
    •Fatigue (6%)
    •Hallucinations (5-6%)
    •Dry mouth (4-5%)

    Restless legs syndrome

    •Nausea (16%)
    •Headache (16%)
    •Fatigue (9%)
    •Sleepiness (6%)
    •Constipation (4%)
    Common Side Effects for

    Selegiline tablets and capsules:

    •Nausea (20%)
    •Dizziness (14%)
    •Stomach pain (8%)
    •Confusion (6%)
    •Hallucinations (6%)
    •Dry mouth (6%)

    Zelapar (selegiline) ODTs:

    •Nausea (11%)
    •Dizziness (11%)
    •General body pain (8%)
    •Headache (7%)
    •Trouble sleeping (7%)
    •Runny nose (7%)
    •Involuntary movements (dyskinesia; 6%)
    •Skin irritation (6%)
    •Back pain (5%)
    •Indigestion (5%)
    •Inflamed or sore mouth (5%)
    •Other irritation in the mouth (e.g., pain when swallowing, pain in mouth, mouth sores)

  • Warnings of Mirapex vs. Zelapar

    Common Side Effects for
    •Extreme sleepiness
    •Changes in blood pressure and higher risk of falls
    •Intense urges
    •Hallucinations and behavior changes
    •Difficulty controlling body movements
    •Changes to your posture
    •Severe muscle damage (rhabdomyolysis)
    •Worsening symptoms of RLS
    Common Side Effects for
    •High blood pressure
    •Serotonin syndrome
    •Extreme sleepiness and falling asleep during activities
    •Low blood pressure and risk of falls
    •Difficulty controlling body movements
    •Hallucinations and behavior changes
    •Intense urges
    •Caution in people with phenylketonuria (PKU) - Zelapar ODTs only

  • Prices with our coupons for Mirapex vs. Zelapar

    Learn more about Pramipexole
    Learn more about Selegiline

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