Key takeaways
Pramipexole (Mirapex, Mirapex ER) and Stalevo (carbidopa/levodopa/entacapone) are both used to treat Parkinson's disease (PD), but they work differently and have different uses. Pramipexole is a dopamine agonist that helps improve movement problems by raising dopamine levels in the brain. It is also used to treat moderate-to-severe restless legs syndrome (RLS). Pramipexole is available in both immediate-release and extended-release forms, with the immediate-release needing to be taken three times a day and the extended-release taken once daily. On the other hand, Stalevo combines three medications—carbidopa, levodopa, and entacapone—to help relieve PD symptoms by increasing and maintaining dopamine levels in the brain. Stalevo is typically taken multiple times per day and is available in various strengths. While both medications can cause sleepiness and dizziness, Stalevo can also cause diarrhea and changes in the color of bodily fluids, which are not common with pramipexole. Additionally, pramipexole can cause compulsive behaviors and hallucinations, which are less commonly associated with Stalevo. Both medications are available in generic forms, making them more affordable options.
