Key takeaways
Pramipexole (Mirapex, Mirapex ER) and Sinemet (carbidopa/levodopa) are both used to treat Parkinson's disease (PD), but they work differently. Pramipexole is a dopamine agonist that helps raise dopamine levels in the brain to improve mpvement problems, while Sinemet combines two medications - carbidopa and levodopa - to increase dopamine levels. Pramipexole is available in both immediate-release and extended-release forms, with the immediate-release needing to be taken three times a day and the extended-release once daily. Sinemet also comes in immediate-release and extended-release forms, but it generally needs to be taken multiple times per day regardless of the form.Pramipexole can cause side effects like extreme sleepiness, dizziness, and compulsive behaviors, while Sinemet can cause involuntary movements, dark-colored urine, and hallucinations. Both medications can make you very sleepy and should not be stopped suddenly without consulting your healthcare provider.
