Key takeaways
Ropinirole (generic name) and Sinemet (carbidopa/levodopa) are both used to treat Parkinson's disease (PD), but they work differently. Ropinirole is a dopamine agonist that mimics dopamine in the brain, while Sinemet combines carbidopa and levodopa to increase dopamine levels. Ropinirole is also used for restless legs syndrome (RLS), whereas Sinemet is not. Ropinirole is available as immediate-release and extended-release tablets, while Sinemet comes in immediate-release, extended-release, and orally disintegrating tablets. Ropinirole can cause side effects like impulsive behavior and hallucinations, while Sinemet can cause dark-colored saliva, sweat, and urine. Both medications can make you very sleepy and should not be stopped suddenly without consulting your provider. Generic versions of both medications are available, making them more affordable.
