Key takeaways
Tolcapone (Tasmar) and ropinirole are both medications used to treat Parkinson's disease (PD), but they work in different ways and have distinct uses. Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that helps stabilize levodopa levels in the brain, and it must be used with carbidopa/levodopa. It can cause serious liver damage, requiring regular liver monitoring. Ropinirole, on the other hand, is a dopamine agonist that mimics dopamine in the brain. It can be used alone for PD and also treats restless legs syndrome (RLS). Ropinirole can cause impulsive behaviors, and it should not be stopped suddenly due to withdrawal risks. While both medications can cause dizziness and hallucinations, tolcapone can also cause liver damage.
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