Key takeaways
Tolcapone (Tasmar) and bromocriptine (Parlodel) are both used to treat Parkinson's disease (PD), but they work in different ways and have different uses. Tolcapone (Tasmar) is a catechol-O-methyltransferase (COMT) inhibitor that helps stabilize levodopa levels in the brain, and it must be used with carbidopa/levodopa. Bromocriptine (Parlodel), on the other hand, is a dopamine agonist that activates dopamine receptors and can be used alone for PD, as well as for conditions like high prolactin levels and acromegaly. Tolcapone (Tasmar) has a significant risk of liver damage and requires regular liver monitoring, while bromocriptine (Parlodel) can cause changes in blood pressure and has a risk of high blood pressure, including if used after childbirth. Bromocriptine (Parlodel) and Tolcapone (Tasmar) are both available as a generic, making them more affordable. Both medications can cause dizziness and sleepiness, so you should be cautious when driving or doing activities that require focus.
