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Compare Tasmar vs. Zelapar

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Tolcapone (Tasmar)
    Selegiline
  • Tolcapone (Tasmar)
    Selegiline

  • Summary of Tasmar vs. Zelapar

    Summary for COMT inhibitor
    Prescription only

    Tolcapone (Tasmar) is an oral add-on medication for Parkinson's disease (PD). It's usually used when carbidopa/levodopa isn't controlling PD symptoms well enough.

    Summary for MAO-B inhibitor
    Prescription only

    Selegiline helps relieve symptoms of Parkinson's disease in people who have "off" episodes as their carbidopa/levodopa medication starts to wear off. Selegiline is a type of monoamine oxidase inhibitor (MAOI), which is a drug class that has many drug interactions. Generic selegiline tablets and capsules are taken twice per day; the brand name for the pills, Eldepryl, is no longer available. Selegiline also comes as orally disintegrating tablets (ODTs) under the brand name Zelapar that are dissolved on the tongue once per day. Side effects include changes in blood pressure, nausea, and dizziness.

  • Indications of Tasmar vs. Zelapar

    Indications for
    •Parkinson's disease (PD); as add-on treatment to carbidopa/levodopa
    Indications for
    •Relief of "off" episodes in people with Parkinson's disease (PD) who are taking a carbidopa/levodopa medication

  • Pros and Cons of Tasmar vs. Zelapar

    Pros and Const for COMT inhibitor
    Pros
    •Can help relieve PD symptoms that occur between levodopa doses; sometimes called the "wearing-off" effect
    •For the brand medication (Tasmar), the manufacturer offers a copay savings card for those with private insurance.
    Cons
    •Can cause liver failure; not a good option for people with liver problems
    •Has a lot of side effects
    •Cannot be taken alone; only used as an add-on medication
    •Can be expensive
    Pros and Const for MAO-B inhibitor
    Pros
    •Extends the actions of carbidopa/levodopa to relieve PD symptoms
    •Comes as tablets, capsules, and ODTs
    •Taken once or twice a day, depending on the form of the medication
    Cons
    •Doesn't work well when you take it by itself; must take in addition to a carbidopa/levodopa medication
    •Commonly causes nausea and dizziness

  • Common Side Effects of Tasmar vs. Zelapar

    Common Side Effects for
    •Involuntary movements (dyskinesia, 42%)
    •Nausea (30%)
    •Sleep problems (24%)
    •Excessive dreaming (21%)
    •Muscle contractions and cramps (17—19%)
    •Loss of appetite (19%)
    •Sleepiness (18%)
    •Low blood pressure (17%)
    •Diarrhea (16%)
    •Dizziness (13%)
    •Confusion (11%)
    •Headache (10%)
    Common Side Effects for

    Selegiline tablets and capsules:

    •Nausea (20%)
    •Dizziness (14%)
    •Stomach pain (8%)
    •Confusion (6%)
    •Hallucinations (6%)
    •Dry mouth (6%)

    Zelapar (selegiline) ODTs:

    •Nausea (11%)
    •Dizziness (11%)
    •General body pain (8%)
    •Headache (7%)
    •Trouble sleeping (7%)
    •Runny nose (7%)
    •Involuntary movements (dyskinesia; 6%)
    •Skin irritation (6%)
    •Back pain (5%)
    •Indigestion (5%)
    •Inflamed or sore mouth (5%)
    •Other irritation in the mouth (e.g., pain when swallowing, pain in mouth, mouth sores)

  • Warnings of Tasmar vs. Zelapar

    Common Side Effects for
    •Serious liver damage
    •Sleepiness or falling asleep during activities
    •Low blood pressure and fainting
    •Hallucinations and changes in behavior and thoughts
    •Impulsive behavior
    •Muscle damage (rhabdomyolysis)
    Common Side Effects for
    •High blood pressure
    •Serotonin syndrome
    •Extreme sleepiness and falling asleep during activities
    •Low blood pressure and risk of falls
    •Difficulty controlling body movements
    •Hallucinations and behavior changes
    •Intense urges
    •Caution in people with phenylketonuria (PKU) - Zelapar ODTs only

  • Prices with our coupons for Tasmar vs. Zelapar

    Learn more about Tolcapone
    Learn more about Selegiline

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