Key takeaways
Entacapone (Comtan) and Stalevo (carbidopa/levodopa/entacapone) are both used to treat Parkinson's disease (PD), but they have some key differences. Entacapone (Comtan) is a COMT inhibitor that must be taken with each dose of carbidopa/levodopa to help extend the effect of levodopa by preventing its breakdown. It is available as both a brand-name and generic medication. On the other hand, Stalevo combines three medications—carbidopa, levodopa, and entacapone—into a single pill, which can be more convenient as it reduces the number of pills you need to take. However, before switching to Stalevo, you might need to find the right dose by taking carbidopa/levodopa and entacapone separately. Both medications can cause similar side effects like involuntary movements, nausea, and changes in the color of your urine, but Stalevo can also cause changes in the color of your saliva and urine. Additionally, Stalevo is available in multiple strengths, allowing for more precise dosing adjustments.
