Key takeaways
Entacapone (Comtan) and pramipexole (Mirapex, Mirapex ER) are both used to treat Parkinson's disease (PD), but they work differently and have different uses. Entacapone is a COMT inhibitor that helps carbidopa/levodopa work better by preventing its breakdown, and it must be taken with each dose of carbidopa/levodopa. Pramipexole, on the other hand, is a dopamine agonist that can be used alone and is also used to treat restless legs syndrome (RLS). Pramipexole is available in both immediate-release and extended-release forms, while entacapone is only available in one form. Common side effects of entacapone include involuntary movements and muscle spasms, whereas pramipexole can cause swelling, dry mouth, and dizziness. Both medications can cause serious side effects like hallucinations and muscle damage, but pramipexole also has a risk of compulsive behaviors and worsening RLS symptoms.
