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SGLT2 Inhibitor / Biguanide Combinations

SGLT2 inhibitor and biguanide combinations are used to treat type 2 diabetes. The SGLT2 inhibitor lowers blood sugar by removing excess glucose through the kidneys. The biguanide does so by lowering the amount of glucose absorbed and made by the body, and making the body more sensitive to insulin.

Why are sglt2 inhibitor biguanide combinations prescribed?

  1. Diabetes Type 2 (100%)

Key takeaways

SGLT2 inhibitor / biguanide combinations are used to treat Type 2 diabetes and reduce the risk of cardiovascular events in certain adults with Type 2 diabetes. These medications work by combining two actions: SGLT2 inhibitors which help your kidneys remove excess glucose (sugar) through urine and biguanides which reduce glucose production in your liver and improve your body's sensitivity to your natural insulin. These combinations are available as oral tablets. Examples include dapagliflozin / metformin (Xigduo XR), empagliflozin / metformin (Synjardy, Synjardy XR), and canagliflozin / metformin (Invokamet, Invokamet XR).

Prices for popular SGLT2 Inhibitor / Biguanide Combinations medications
Viewing 6 of 6 medications
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Xigduo XR (dapagliflozin / metformin ER)

as low as$431
Xigduo XR (dapagliflozin/metformin) is a combination of 2 medicines used to treat type 2 diabetes. This medicine lowers blood sugar. It is slightly more popular than comparable drugs. There are currently no generic alternatives to Xigduo XR.

GoodRx has partnered with InsideRx and AstraZeneca to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Xigduo XR is not covered by most Medicare and insurance plans.
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Synjardy XR

as low as$609
Synjardy XR (empagliflozin and metformin) is used to lower blood sugar and treat type 2 diabetes. Synjardy XR is less popular than other SGLT2 inhibitor/biguanide combinations. There are currently no generic alternatives to Synjardy XR.

Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Synjardy XR is covered by some Medicare and insurance plans.
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Synjardy

as low as$609
Synjardy (empagliflozin/metformin) is used to treat type 2 diabetes. Synjardy is an SGLT2 inhibitor/biguanide combination, which works by lowering blood sugar by removing excess glucose through the kidneys and lowering the amount of glucose that is made and absorbed by the body. The most common form of Synjardy is a 12.5mg/1000mg tablet. It is also available as 12.5mg/500mg, 5mg/1000mg, and 5mg/500mg tablets. There are currently no generic alternatives for Synjardy. It is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Segluromet

as low as$348
ERTUGLIFLOZIN; METFORMIN treats type 2 diabetes. It works by decreasing your blood sugar (glucose). Changes to diet and exercise are often combined with this medication.
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Invokamet

as low as$580
CANAGLIFLOZIN; METFORMIN treats type 2 diabetes. It works by decreasing your blood sugar (glucose). Changes to diet and exercise are often combined with this medication.
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Invokamet XR

as low as$580
CANAGLIFLOZIN; METFORMIN treats type 2 diabetes. It works by decreasing your blood sugar (glucose). Changes to diet and exercise are often combined with this medication.
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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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