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Janumet vs. Jentadueto

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Janumet

(sitagliptin / metformin)

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Jentadueto

(linagliptin / metformin)

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Summary for Janumet

Prescription only

Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.

Indications for Janumet

Pros and Cons for Janumet

Pros

Cons

  • Must take twice a day with meals
  • Only available as a fixed dose, so can be hard to make dose adjustments
  • Not a good option for people with severe kidney problems
  • Not approved for people with Type 1 diabetes

Common Side Effects for Janumet

Warnings for Janumet

  • Lactic acidosis
  • Inflammation of the pancreas (pancreatitis)
  • Risk of heart failure
  • Sudden kidney problems
  • Low vitamin B12 levels
  • Low blood sugar (hypoglycemia) when taken with certain diabetes medications
  • Joint pain
  • Severe skin reaction
  • Serious allergic reactions

Summary for Jentadueto

Prescription only

Jentadueto (linagliptin / metformin) is a combination medication used along with a healthy diet and exercise to treat Type 2 diabetes. It's taken by mouth, either once or twice daily, depending on the formulation your provider prescribes (immediate-release or extended-release). Both formulations of Jentadueto (linagliptin / metformin) need to be taken with food to prevent stomach upset. Some of the more common side effects of this medication include diarrhea, cough, and runny or stuffy nose.

Indications for Jentadueto

  • Type 2 diabetes in adults

Pros and Cons for Jentadueto

Pros

  • Combines two medications into one pill for convenience
  • Taken once or twice daily, depending on which formulation you take
  • Taken by mouth

Cons

  • Need to take with meals
  • Not safe for use in people with moderate-to-severe kidney disease
  • More likely to cause high levels of acid compared to some other medications for diabetes

Common Side Effects for Jentadueto

  • Cough, runny or stuffy nose, and other symptoms of an upper respiratory tract infection 6%)
  • Diarrhea (6%)

Warnings for Jentadueto

  • Lactic acidosis (too much acid in your body)
  • Pancreas problems
  • Heart failure
  • Serious allergic reactions
  • Low vitamin B12 levels
  • Joint pain
  • Severe skin reactions

Prices with our coupons for Janumet vs. Jentadueto

Price Card Drug Icon
Janumet60 tablets / 50mg/1000mg
$332.80$507.67
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Price Card Drug Icon
Linagliptin/Metformin60 tablets / 2.5mg/1000mg of
$44.37$545.96
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