Key takeaways
Janumet (sitagliptin / metformin) and Jentadueto (linagliptin / metformin) are both combination medications used to treat Type 2 diabetes. They belong to the same drug class, combining a DPP-4 inhibitor with metformin, a biguanide, to help control blood sugar levels. However, they differ in their specific DPP-4 inhibitors: Janumet contains sitagliptin, while Jentadueto contains linagliptin. Janumet is typically taken twice daily with meals, while Jentadueto offers both immediate-release (twice daily) and extended-release (once daily) formulations. Neither Janumet and Jentadueto extended release have a generic version available, which can affect cost. Common side effects for Janumet include diarrhea, upper respiratory tract infection, and headache, whereas Jentadueto may cause diarrhea, cough, and a runny or stuffy nose. Both medications carry risks of lactic acidosis and pancreatitis, but they have different drug interactions and specific warnings, such as Janumet's interaction with contrast dyes and Jentadueto's interaction with ranolazine.
