Key takeaways
Janumet (sitagliptin / metformin) and Janumet XR (sitagliptin / metformin) are both medications used to treat Type 2 diabetes. They belong to the same drug class, combining a DPP-4 inhibitor (sitagliptin) and a biguanide (metformin) to help control blood sugar levels. The main difference between the two is their release and dosing schedule. Janumet is an immediate-release tablet taken twice a day with meals, while Janumet XR is an extended-release tablet taken once a day, typically with the evening meal. Both medications are only available as brand-name versions, with no generic options. Common side effects for both include diarrhea, upper respiratory tract infection, and headache. You should avoid alcohol with both medications, as it can increase the risk of lactic acidosis, a serious condition. Additionally, both medications are not suitable for people with severe kidney problems or Type 1 diabetes.
