Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Janumet vs. Xigduo XR

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Janumet (sitagliptin / metformin)
    Xigduo xr (dapagliflozin / metformin)
  • Janumet (sitagliptin / metformin)
    Xigduo xr (dapagliflozin / metformin)

  • Summary of Janumet vs. Xigduo XR

    Summary for DPP-4 inhibitor / Biguanide
    Prescription only

    Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.

    Summary for SGLT2 inhibitor / Biguanide
    Prescription only

    Xigduo XR is a combination medication that contains dapagliflozin (an SGLT2 inhibitor) and metformin (a biguanide). It's taken along with a healthy diet and exercise to treat Type 2 diabetes in people ages 10 years and older. In addition, dapagliflozin in Xigduo XR can help lower the risk of worsening heart failure or chronic kidney disease (CKD) in certain people. Xigduo XR (dapagliflozin / metformin) is taken by mouth once daily in the morning. It's best to take this medication with food since it might cause stomach upset. Other possible side effects include yeast infection, cold symptoms, and urinary tract infection (UTI).

  • Indications of Janumet vs. Xigduo XR

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes (T2D)

  • Pros and Cons of Janumet vs. Xigduo XR

    Pros and Const for DPP-4 inhibitor / Biguanide
    Pros
    •Combines the effects of two diabetes medications into one tablet
    •Less likely to cause weight gain and low blood sugar compared to other diabetes medications
    •Can lower A1C by up to 2% in 6 months
    Cons
    •Must take twice a day with meals
    •Only available as a fixed dose, so can be hard to make dose adjustments
    •Not a good option for people with severe kidney problems
    •Not approved for people with Type 1 diabetes
    Pros and Const for SGLT2 inhibitor / Biguanide
    Pros
    •Combines two medications into one pill for convenience
    •Only taken once a day in the morning
    •Lowers your risk for certain complications of diabetes, such as heart and kidney problems
    Cons
    •Might cause you to urinate more often
    •Need to take with a meal to prevent stomach upset
    •Raises risk of genital and urinary tract infections

  • Common Side Effects of Janumet vs. Xigduo XR

    Common Side Effects for
    •Diarrhea (8%)
    •Upper respiratory tract infection (6%)
    •Headache (6%)
    Common Side Effects for
    •Redness, itching, and other symptoms of a genital yeast infection (4-9%)
    •Pain or discomfort while urinating and other symptoms of an urinary tract infection (6%)
    •Sore throat, stuffy nose, and other symptoms of the common cold (5-6%)
    •Diarrhea (4-6%)
    •Headache (3-5%)

  • Warnings of Janumet vs. Xigduo XR

    Common Side Effects for
    •Lactic acidosis
    •Inflammation of the pancreas (pancreatitis)
    •Risk of heart failure
    •Sudden kidney problems
    •Low vitamin B12 levels
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Joint pain
    •Severe skin reaction
    •Serious allergic reactions
    Common Side Effects for
    •Lactic acidosis (too much lactic acid in the blood)
    •Ketoacidosis (too many ketones in the blood)
    •Low fluids in the body (leading to low blood pressure, dehydration, or kidney problems)
    •Genital and urinary tract infections
    •Low vitamin B12 levels
    •Rare risk of serious skin infection
    •Low blood sugar (hypoglycemia) when used with other diabetes medications

  • Prices with our coupons for Janumet vs. Xigduo XR

    Learn more about Janumet
    Learn more about Xigduo xr

Compare other Diabetes Type 2 drugs

Glucotrol vs JanumetGlyburide vs JanumetHuman Insulin vs JanumetJanumet vs ActosJanumet vs Janumet XrJanumet vs JentaduetoJanumet vs MetforminJanumet vs OnglyzaJanumet vs PrandinJanumet vs StarlixJanumet vs Xigduo XrJanuvia vs JanumetJardiance vs JanumetPrecose vs JanumetToujeo vs JanumetActos vs BaqsimiActos vs InvokanaFarxiga vs ActosGlucotrol vs ActosGlyburide vs ActosHumalog vs ActosHuman Insulin vs ActosInvokamet vs ActosJanuvia vs ActosJardiance vs ActosLantus vs ActosLevemir vs ActosMetaglip vs ActosMetformin vs ActosNesina vs Actos
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.