Key takeaways
Janumet (sitagliptin / metformin) and Xigduo XR (dapagliflozin / metformin) are both medications used to treat Type 2 diabetes. They both contain metformin, a biguanide that helps lower blood sugar levels. However, they differ in their other active ingredients and how they work. Janumet includes sitagliptin, a DPP-4 inhibitor, which helps insulin stay in the body longer and reduces glucagon production. Xigduo XR contains dapagliflozin, an SGLT2 inhibitor, which helps remove excess sugar through urine and reduces stress on the heart and kidneys. Janumet is taken twice daily with meals, while Xigduo XR is taken once daily in the morning. Both medications are only available as brand-name versions, with no generic options. Common side effects of Janumet include diarrhea, headaches and upper respiratory tract infections, while Xigduo XR may cause urinary tract infections and genital yeast infections. Both medications can interact with alcohol and other diabetes medications, increasing the risk of low blood sugar.
