provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Dapagliflozin / Metformin ER Coupon - Dapagliflozin / Metformin ER 5mg/1000mg tablet

dapagliflozin / metformin

Generic Xigduo XR
Used for Diabetes Type 2
Used for Diabetes Type 2

Xigduo XR is a combination medication that contains dapagliflozin (an SGLT2 inhibitor) and metformin (a biguanide). It's taken along with a healthy diet and exercise to treat Type 2 diabetes in people ages 10 years and older. In addition, dapagliflozin in Xigduo XR can help lower the risk of worsening heart failure or chronic kidney disease (CKD) in certain people. Xigduo XR (dapagliflozin / metformin) is taken by mouth once daily in the morning. It's best to take this medication with food since it might cause stomach upset. Other possible side effects include yeast infection, cold symptoms, and urinary tract infection (UTI).

Last reviewed on September 17, 2024
basics-icon

What is Xigduo XR (dapagliflozin / metformin)?

What is Xigduo XR (dapagliflozin / metformin) used for?

How Xigduo XR (dapagliflozin / metformin) works

Xigduo XR (dapagliflozin / metformin) is a combination of two medications.

  • Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It lowers blood sugar levels by getting rid of extra sugar through the urine. It also helps your body get rid of sodium (salt) and water, which takes stress off the heart and kidneys.

  • Metformin is a biguanide that lowers blood sugar levels by lowering the amount of sugar that your liver makes, as well as the amount of sugar the body absorbs through the intestines. It also makes your body more sensitive to the effects of insulin.

Are you looking for information on metformin or dapagliflozin (Farxiga) instead?

Drug Facts

Common BrandsXigduo XR
Drug ClassSGLT2 inhibitor / Biguanide
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Xigduo XR (dapagliflozin / metformin) essentials

coupon-save-icon

Get your GoodRx coupon

Avg retail price
$496.22(save 40.59%)
GoodRx discount
$294.79
See prices
basics-icon

What are the side effects of Xigduo XR (dapagliflozin / metformin)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Redness, itching, and other symptoms of a genital yeast infection (4-9%)
  • Pain or discomfort while urinating and other symptoms of an urinary tract infection (6%)
  • Sore throat, stuffy nose, and other symptoms of the common cold (5-6%)
  • Diarrhea (4-6%)
  • Headache (3-5%)

Other Side Effects

  • Nausea
  • Constipation
  • Back pain
  • Dizziness
  • Cough
  • Urinating more often

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Too much lactic acid: confusion, feeling weak, fast or slow heartbeat, rapid breathing, no appetite, nausea, vomiting, stomach pain
  • High ketone levels in the blood: trouble breathing, vomiting, belly pain, dry skin and mouth, feeling very tired, fruity-smelling breath
  • Serious kidney problems: confusion, weakness, tiredness, urinating less than usual
  • Dehydration (dangerously low body fluids): dizziness, lightheadedness, confusion, dark-colored urine
  • Serious genital infection: pain, swelling, or redness in the genital area, fever, weakness
  • Severe allergic reaction: hives, swelling in the face or throat, trouble breathing

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Xigduo XR (dapagliflozin / metformin)

thumbs-up

Pros

Combines two medications into one pill for convenience

Only taken once a day in the morning

Lowers your risk for certain complications of diabetes, such as heart and kidney problems

thumbs-down

Cons

Might cause you to urinate more often

Need to take with a meal to prevent stomach upset

Raises risk of genital and urinary tract infections

pharmacist-tips

Pharmacist tips for Xigduo XR (dapagliflozin / metformin)

pharmacist
  • Swallow Xigduo XR (dapagliflozin / metformin) whole and don't crush, cut, or chew it because this could affect the way the medication works for you.

    • Take Xigduo XR (dapagliflozin / metformin) with food. The metformin in this medication can cause stomach problems, including diarrhea, nausea, vomiting, and belly pain. Food can help lower the risk of these side effects.

      • If you feel nauseous, have trouble breathing, or have a racing heart, stop taking Xigduo XR (dapagliflozin / metformin) and get medical attention right away. These can be signs of too much lactic acid in your blood, which sometimes can require treatment in the hospital.

        • If you have nausea, vomiting, tiredness, or fruity breath, stop taking Xigduo XR (dapagliflozin / metformin) and get medical attention right away. These can be signs of another serious condition called ketoacidosis, which can be life-threatening.

          • It's best to avoid alcohol when possible during treatment with Xigduo XR (dapagliflozin / metformin). Drinking alcohol with this medication can cause dangerously low blood sugar. Alcohol can also raise your risk of having too much acid in your blood. If it's difficult for you to stop drinking alcohol completely, ask your prescriber what's a safer limit for you.

            • Xigduo XR (dapagliflozin / metformin) can cause genital yeast infections or urinary tract infections. Make sure to practice good hygiene to lower your risk of these infections. Let your prescriber know right away if you experience pain while urinating, stomach pain, blood in the urine, genital itching, or discharge from the genitals.

              • If you're scheduled for a major surgery where you need to fast, let your primary care provider know ahead of time. They might ask you to pause your treatment with Xigduo XR (dapagliflozin / metformin) a few days before your surgery. This helps lower your risk of having dangerous acid levels in the body. Follow up with your prescriber after surgery to discuss when you should restart Xigduo XR (dapagliflozin / metformin).

                • It's important to have a healthy and balanced diet and exercise regularly to keep your blood sugar under control. Make sure to work with your care team on a diet and exercise plan while taking Xigduo XR (dapagliflozin / metformin).

                  • You might sometimes see a soft mass in your stools that looks like the Xigduo XR (dapagliflozin / metformin) tablet. This is the inactive ingredients from the medication and isn't harmful.

                    • Talk to your prescriber if you're pregnant, since Xigduo XR (dapagliflozin / metformin) can potentially cause harm to babies. They can talk with you about safer options to manage diabetes during pregnancy.

                      faqs

                      Frequently asked questions about Xigduo XR (dapagliflozin / metformin)

                      Can Xigduo XR (dapagliflozin / metformin) cause UTI?
                      Yes, Xigduo XR (dapagliflozin / metformin) can raise your risk of getting a urinary tract infection (UTI). This is because dapagliflozin causes more sugar to get into your urine, which can lead to more growth of bacteria. If you already have UTIs often, then Xigduo XR (dapagliflozin / metformin) might not be a good option for you. Contact your prescriber if you notice any signs of a UTI, such as burning while passing urine, urinating more frequently, pain in your lower stomach, or blood in your urine.
                      Can Xigduo XR (dapagliflozin / metformin) cause kidney damage?
                      Xigduo XR (dapagliflozin / metformin) isn't likely to cause kidney damage. In fact, Xigduo XR (dapagliflozin / metformin) might be a recommended option for people who have both diabetes and kidney problems. This is because metformin and dapagliflozin can help slow the worsening of kidney problems in certain people. But keep in mind Xigduo XR (dapagliflozin / metformin) isn't recommended for people with severe kidney problems or for those who are on dialysis. This is because metformin in Xigduo XR (dapagliflozin / metformin) can raise the risk of having a higher level of acid in your blood (lactic acidosis).
                      Does Xigduo XR (dapagliflozin / metformin) cause weight loss?
                      You might experience some weight loss after starting Xigduo XR (dapagliflozin / metformin). Metformin might cause moderate weight loss because it lowers the amount of sugar your liver makes and the amount of sugar your body absorbs through food. Dapagliflozin is more likely to cause weight loss from loss of water weight at the beginning of treatment, but it can result in loss of body fat as you continue treatment. If you have more questions about Xigduo XR (dapagliflozin / metformin) and body weight, talk to your healthcare team.
                      Can I take Xigduo XR (dapagliflozin / metformin) at night?
                      You're recommended to take Xigduo XR (dapagliflozin / metformin) in the morning. This is because dapagliflozin in Xigduo causes you to urinate more often. So it's best to take this medication in the morning to avoid needing to use the bathroom too often at night. If it's challenging for you to take Xigduo XR (dapagliflozin / metformin) in the morning, let your prescriber know and they work with you to find a time to take this medication. The most important thing is that you take it consistently and at the same time every day.
                      How long does it take for Xigduo XR (dapagliflozin / metformin) to start working?
                      Xigduo XR (dapagliflozin / metformin) can start to work within the first week you start taking it. But it can take a few months to see the full blood sugar-lowering effects of the medication. Also, your prescriber might need to adjust your dose in order for you to get the most out of your treatment. This can take time. Make sure to keep track of your blood sugar levels at home and attend your follow-up appointments so your prescriber can check how well Xigduo XR (dapagliflozin / metformin) is working for you.
                      Can you take Xigduo XR (dapagliflozin / metformin) twice a day?
                      No. Xigduo XR (dapagliflozin / metformin) should be taken only once a day. Taking it more often can lead to serious side effects, like diarrhea and lactic acidosis (too much acid in the blood).
                      How long does Xigduo XR (dapagliflozin / metformin) stay in your system?
                      It takes about 3 days for most of dapagliflozin and about 1 day for metformin to be cleared from your system. This is based on the half-lives for these medications, which is a measure of how long it takes for half of the dose to leave your body. For some people, it could take longer or quicker for these medications to leave your system. This is because certain medications that interact with Xigduo XR (dapagliflozin / metformin) or health conditions can affect how long it takes for the medication to leave your body.
                      Is Xigduo XR (dapagliflozin / metformin) available as a generic?
                      No. Xigduo XR (dapagliflozin / metformin) is brand name only and not available as a generic medication. However, the individual ingredients in Xigduo XR (dapagliflozin / metformin) are both available as lower cost generics.
                      GoodRxEducationalIcon

                      How to save using GoodRx

                      Compare Prices
                      1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                      Select your free coupon
                      2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                      Show coupon to your pharmacist
                      3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                      Get free couponLearn more
                      warings-icon

                      What are the risks and warnings for Xigduo XR (dapagliflozin / metformin)?

                      Xigduo XR (dapagliflozin / metformin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                      risk-warning

                      Lactic acidosis (too much lactic acid in the blood)

                      • Risk factors: Kidney or liver problems | Heart failure or heart attack | Age 65 years or older | Not eating food or fasting before surgery | Drinking large amounts of alcohol | Imaging procedure using contrast dye | Taking certain medications that affect the kidneys or acid-base balance

                        Metformin in Xigduo XR (dapagliflozin / metformin) can cause a rare, but serious medical condition called lactic acidosis (too much lactic acid in your blood). If left untreated, this condition can lead to other health problems, including organ failure, which can be life-threatening. Discuss with your primary care provider about your medical history before starting Xigduo XR (dapagliflozin / metformin) and any planned procedures during treatment. They can check for your risk of lactic acidosis. Get medical attention right away if you experience fast breathing, irregular heartbeat, or weakness. These can be signs that you have too much lactic acid in your blood.

                        risk-warning

                        Ketoacidosis (too many ketones in the blood)

                        • Risk factors: Lowered calorie intake | After surgery | Sudden fever | Pancreas problems | Stopping or lowering dose of insulin | Drinking too much alcohol

                          Dapagliflozin in Xigduo XR (dapagliflozin / metformin) can cause a rare but serious medical condition called diabetic ketoacidosis (DKA). This condition happens when you don't have enough insulin to help your body use blood sugar as a source of energy. When this occurs, your body gets energy another way by breaking down fat into a type of acid called ketone. But it can be dangerous when too many acidic ketones build up in the blood. Seek medical attention right away if you notice signs and symptoms of ketoacidosis, such as trouble breathing, vomiting, belly pain, dry skin and mouth, feeling very tired, and fruity-smelling breath.

                          risk-warning

                          Low fluids in the body (leading to low blood pressure, dehydration, or kidney problems)

                          • Risk factors: 65 years and older | History of kidney problems | Taking certain loop diuretics (water pills) | Low salt (sodium) diet

                            Xigduo XR (dapagliflozin / metformin) can cause low levels of fluids in the body because dapagliflozin might cause you to urinate more. This can lead to dehydration, low blood pressure, or sudden kidney injury. Very rarely, the kidney problems can require hospitalization or dialysis. You're at higher risk for these problems if you have kidney problems or are an older adult. If you have any risk factors for low fluid levels, talk with your prescriber about how you can safely take Xigduo XR (dapagliflozin / metformin). You might need to get blood and urine tests done before or during treatment so your provider can check your kidney health. Speak with your care team if you feel dizzy, confused, chest pain, or notice you're urinating less than usual while taking Xigduo XR (dapagliflozin / metformin). These might be symptoms of dehydration, low blood pressure, or kidney problems.

                            risk-warning

                            Genital and urinary tract infections

                            • Risk factors: History of urinary tract infections (UTIs) or genital yeast infections

                              Dapagliflozin in Xigduo XR (dapagliflozin / metformin) might raise your risk of genital and urinary tract infections, including yeast and fungal infections. Your risk of a yeast infection is higher if you've had frequent or long-term genital yeast infections in the past. In rare cases, these genital infections can be serious and life-threatening, and they might require hospitalization or surgery. Let your prescriber know if you have genital itching, pain while urinating, cloudy urine, or back pain. These can be signs of a genital yeast infection or kidney infection. Get medical attention right away if you have symptoms of a more serious infection, like pain, swelling, or redness in the genital area, along with fever and weakness.

                              risk-warning

                              Low vitamin B12 levels

                              • Risk factors: Long-term use of metformin | Lower than average calcium or vitamin B12 intake or absorption

                                Taking diabetes medications that contain metformin, including Xigduo XR (dapagliflozin / metformin), for a long period of time can cause your vitamin B12 levels to drop. Having low vitamin B12 levels can lead to a higher risk of anemia. Your prescriber will check your vitamin B12 levels through blood work every 2 to 3 years. If needed, your prescriber might recommend that you take vitamin B12 supplementation. Let your care team know if you frequently have low energy, dizziness, muscle problems, or tingling or numbness in your hands and feet.

                                risk-warning

                                Rare risk of serious skin infection

                                Although extremely rare, people who took dapagliflozin have developed a very serious skin infection called necrotizing fasciitis. If you develop this type of infection, your prescriber will ask you to stop taking Xigduo XR (dapagliflozin / metformin) and get treated with antibiotics right away. Get medical help as soon as possible if you notice swelling, redness, tenderness, in the skin area around the genitals.

                                risk-warning

                                Low blood sugar (hypoglycemia) when used with other diabetes medications

                                • Risk factors: Changes in diet and exercise | Drinking alcohol | Taking other diabetes medications

                                  Xigduo XR (dapagliflozin / metformin) can raise the risk of dangerously low blood sugar when taken together with other diabetes medications, such as insulin and sulfonylureas. You might also be at risk of having low blood sugar if you've recently changed your diet, exercise, and drinking habits. Very low blood sugar can be life-threatening. Symptoms of low blood sugar include feeling shaky; feeling nervous, anxious, or confused; sweating; and having fast heartbeat, body chills, low energy, and hunger. Make sure you know how to check your blood sugar if you get these symptoms and what to do if you have low blood sugar. Talk to your prescriber about your risk for low blood sugar.

                                  dosage

                                  Xigduo XR (dapagliflozin / metformin) dosage forms

                                  The average cost for 60 tablets of 5mg/1000mg of Xigduo XR (dapagliflozin / metformin) is $1730.10 with a free GoodRx coupon. This is -142.99% off the average retail price of $712.00.
                                  tablet
                                  Tablet
                                  DosageQuantityPrice as low asPrice per unit
                                  2.5/1000mg30 tablets$294.79$9.83
                                  5mg/500mg30 tablets$583.18$19.44
                                  10mg/500mg30 tablets$583.18$19.44
                                  5mg/1000mg180 tablets$1730.10$9.61
                                  10mg/1000mg30 tablets$594.00$19.80

                                  Typical dosing for Xigduo XR (dapagliflozin / metformin)

                                  Your prescriber will help determine your starting dose of Xigduo XR (dapagliflozin / metformin) based on the doses of your current diabetes medications and health conditions.

                                  If you're not already taking dapagliflozin, the typical starting dose of dapagliflozin is 5 mg by mouth once daily. If you have heart failure or kidney problems, the typical recommended dose of dapagliflozin is 10 mg once daily.

                                  The maximum dose of Xigduo XR is 10 mg/2000 mg (dapagliflozin / metformin) by mouth once daily.

                                  drug-cost

                                  How much does Xigduo XR (dapagliflozin / metformin) cost?

                                  To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                                  contraindications-icon

                                  Xigduo XR (dapagliflozin / metformin) contraindications

                                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Xigduo XR (dapagliflozin / metformin) will not be safe for you to take.
                                  • Severe kidney problems

                                  • Sudden or long-term high levels of acid in your body (e.g., diabetic ketoacidosis)

                                  alternatives

                                  What are alternatives to Xigduo XR (dapagliflozin / metformin)?

                                  There are a number of medications that your doctor can prescribe in place of Xigduo XR (dapagliflozin / metformin). Compare a few possible alternatives below.
                                  Xigduo XR (dapagliflozin / metformin)
                                  $294.79 Lowest GoodRx priceView Prices
                                  Used for:
                                  • Type 2 diabetes in adults

                                  $123.46 Lowest GoodRx priceView Prices
                                  Used for:
                                  • Type 2 diabetes

                                  • Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease

                                  • Lowering the risk of hospitalization and death due to heart problems in adults with Type 2 diabetes and heart failure

                                  • Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with Type 2 diabetes and chronic kidney disease (CKD)

                                  $611.54 Lowest GoodRx priceView Prices
                                  images

                                  Xigduo XR (dapagliflozin / metformin) images

                                  Pink Oval 1071 5 / 1000 - Dapagliflozin / Metformin 5mg-1000mg Extended-Release Tablet
                                  This medicine is Pink, Oval Tablet Imprinted With "1071 5/1000".Pink Oval 1071 5 / 1000 - Dapagliflozin / Metformin 5mg-1000mg Extended-Release Tablet

                                  Get savings updates for Xigduo XR (dapagliflozin / metformin)

                                  Receive price alerts, news, and other messages from GoodRx about Xigduo XR (dapagliflozin / metformin) and other healthcare topics and relevant savings offers.

                                  By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.

                                  References

                                  Best studies we found

                                  AstraZeneca Pharmaceuticals LP. (2024). Xigduo XR- dapagliflozin and metformin hydrochloride tablet, film coated, extended release [package insert]. DailyMed.

                                  Centers for Disease Control and Prevention. (2024). About necrotizing fasciitis.

                                  National Kidney Foundation. (2023). Dialysis.

                                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                                  Was this page helpful?

                                  Browse medications

                                  View All

                                  Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.