Stribild is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), elvitegravir (Vitekta), emtricitabine (Emtriva), and tenofovir DF (Viread), and one booster medication, cobicistat (Tybost).
Stribild contains an integrase inhibitor (elvitegravir) and two nucleoside reverse transcriptase inhibitors (NRTIs) (emtricitabine, tenofovir). These 3 medications work together to prevent the virus from making copies of itself in your body. The booster medication (cobicistat) slows the metabolism of elvitegravir (Vitekta) and raises the level in the body.
| Common Brands | Stribild |
|---|---|
| Drug Class | HIV ARV Combo |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Cloudy urine
Incidence not known
Abdominal or stomach discomfort or pain
bloody urine
bone fractures
bone pain
change in urination
convulsions
dark-colored urine
decreased appetite
difficulty with swallowing
dizziness
fast or irregular heartbeat
fast, shallow breathing
general feeling of discomfort
increased thirst
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
lower back or side pain
mood changes
muscle pain, cramps, or stiffness
numbness or tingling in the hands, feet, or lips
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
sleepiness
swelling of the face, fingers, or lower legs
tightness in the chest
trouble breathing
unusual tiredness or weakness
yellow eyes and skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Abnormal dreams
headache
Incidence not known
Chills
indigestion
lack or loss of strength
pains in the stomach, side, or abdomen, possibly radiating to the back
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Stribild can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
People who have stopped taking Stribild have had severe worsening of their hepatitis B. Don't stop taking Stribild unless instructed by your healthcare provider. If you are instructed to stop the medication, or switch to a different antiviral medication, make sure you get your labs drawn regularly. This is how your provider will monitor your liver and HBV.
Stribild can cause kidney damage or changes to your kidney function blood tests. This is more common in people with a history of kidney damage. Make sure to have routine labs drawn so your provider can monitor your kidney function.
Although rare, NRTIs including those in Stribild can cause a life-threatening liver problem called lactic acidosis with hepatic steatosis. Most of the cases have been in women. Symptoms can include appetite loss, stomach pain, muscle pain, fast and shallow breathing, extreme tiredness, and sudden weakness. Stop taking Stribild and go to the emergency room right away if this happens.
Stribild interacts with a lot of medications. The interaction usually makes the level of the other medication too high, and can lead to serious or fatal side effects. There are also medications that can lower the amount of Stribild in your body. Talk to your healthcare provider or pharmacist before starting or stopping any medications.
Stribild can lower your bone mineral density and weaken your bones. This can lead to osteoporosis and raise your risk of fractures. Many people take calcium and vitamin D supplements to help prevent this. Your provider may order additional tests to check your bone density if you have a fracture or other risk factors for bone problems.
HIV attacks your immune system. Over time, if the virus isn't treated your body may become defenseless against bacterial and fungal infection. Your HIV medications are very good at killing the virus, and when the number of viruses goes down, your immune system gets started making more cells. Once your immune system gets better, it will start to fight off any infections you might have, which can lead to a lot of inflammation. Even though it's a good thing that your immune system is getting better, too much inflammation can be bad. Your healthcare provider might check for underlying infections (sometimes called opportunistic infections) before starting Stribild especially if it is your first time taking HIV medications. Call your provider if you experience fever, difficulty breathing, or sudden changes to your health after starting Stribild.
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 150mg/150mg/200mg/300mg of | 30 tablets | $4,063.91 | $135.46 |
The recommended dose for adults and children age 12 years and older who weigh more than 35 kg is 1 tablet once a day with food.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Taking Stribild with food allows for more medication to be absorbed into your body. As an added bonus, taking Stribild with food can help prevent nausea and stomach upset.
If you realize you forgot your dose of Stribild, take it as soon as you remember as long as it hasn't been more than 12 hours from your regularly scheduled dose. If more than 12 hours have passed, and it's closer in time to your next dose, skip the missed dose and wait until your regularly scheduled time. Never double up on doses.
Yes, Stribild once daily for 28 days can be used for post-exposure prophlaxis (PEP). PEP is used to prevent HIV infection in people who do not have HIV, and think they have been exposed to HIV. PEP should be started as soon as possible and must be started within 72 hours of the potential exposure.
Yes, Stribild is a single-tablet-regimen that can be taken alone for the treatment of HIV. For some people who might have a resistant type of HIV, they may have to take other HIV ARVs in addition to Stribild. Talk to your provider if you have questions about your HIV regimen.
If you stop taking Stribild without starting an HIV ARV combo replacement, the HIV virus can start to grow and harm your immune system. If you also happen to have hepatitis B, this virus may also flare up and harm your liver.
