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Foundayo
Used for Weight loss
Used for Weight loss
Foundayo (orforglipron) is an oral glucagon-like peptide-1 (GLP-1) receptor agonist. It's approved for weight loss in certain adults. This medication is meant to be used together with a reduced-calorie diet and exercise. Foundayo (orforglipron) comes as tablets and is taken by mouth once a day with or without food. The dose is slowly raised over several weeks. Common side effects include nausea, constipation, and diarrhea.
What is Foundayo (orforglipron)?
What is Foundayo (orforglipron) used for?
- Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition
How Foundayo (orforglipron) works
Foundayo (orforglipron) is a glucagon-like peptide-1 (GLP-1) agonist. It works in a similar way to GLP-1, a hormone your body normally makes that regulates your appetite.
Foundayo (orforglipron) works in a few ways. It slows down digestion, helps you feel fuller after you eat, and controls your appetite. This can help manage your weight.
When does Foundayo (orforglipron) start working?Time passed since treatment started:
Drug facts
| Common Brands | Foundayo |
|---|---|
| Drug Class | GLP-1 agonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Foundayo (orforglipron) essentials
Side effects of Foundayo (orforglipron)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Nausea (26-35%)
- Constipation (20-27%)
- Diarrhea (21-25%)
- Vomiting (13-24%)
- Indigestion (12-16%)
- Stomach pain (13-14%)
- Headache (8-9%)
- Bloating (7-9%)
- Feeling tired (6-9%)
- Belching (6-8%)
- Gastroesophageal reflux disease (GERD; 6-7%)
- Having a lot of gas (5-6%)
- Hair loss (4-5%)
Less Common Side Effects
- Low blood pressure
- Faster heart rate
- Dizziness
- Change in taste
- Uncomfortable or painful sensation when touched
Foundayo (orforglipron) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Kidney damage: nausea, vomiting, trouble urinating, muscle cramps, feeling confused, swelling in the ankles or feet, trouble breathing
- Inflammation of the pancreas: nausea, vomiting, stomach pain (might spread to your back), yellowing of your skin or whites of your eyes
- Gallbladder problems: upper stomach pain, nausea, vomiting, fever, clay-colored stools, yellowing of your skin or whites of your eyes
- Very low blood sugar: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion
- Serious allergic reaction: hives; trouble breathing; swelling of your lips, tongue, throat, or face
When do Foundayo (orforglipron) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Nausea
Constipation
Diarrhea
Vomiting
Indigestion
Stomach pain
More on Foundayo (orforglipron) side effects
The following Foundayo (orforglipron) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
- Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
- Gallbladder problems—severe stomach pain, nausea, vomiting, fever
- Kidney injury (glomerulonephritis)—decrease in the amount of urine, red or dark brown urine, foamy or bubbly urine, swelling of the ankles, hands, or feet
- Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
- Thyroid cancer—new mass or lump in the neck, pain or trouble swallowing, trouble breathing, hoarseness
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Diarrhea
- Hair loss
- Headache
- Loss of appetite
- Nausea
- Upset stomach
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$780.47
Sponsored copay card
Subject to eligibility$25.00
Pros and cons of Foundayo (orforglipron)
Pros
- A pill that's taken once a day at any time of day
- Can take with or without food
Cons
- Can cause nausea, diarrhea, and stomach pain
- Not approved for children
Pharmacist tips for Foundayo (orforglipron)
- Foundayo (orforglipron) works best when you also follow a lower-calorie diet and stay active. Talk to your care team about ways to eat balanced meals. They can also help you choose exercises that fit your lifestyle.
- You can take Foundayo (orforglipron) with or without food and at any time of the day. Try to take it at the same time each day. Creating a daily routine can help you remember to take the medication.
- Swallow the Foundayo (orforglipron) tablets whole. Don't crush, break, or chew them. This is because it can change how the medication works for you.
- Only take one tablet of Foundayo (orforglipron) each day. Taking more than that can raise your risk of side effects.
- When you first start taking Foundayo (orforglipron), you'll begin with a low dose for the first month. Each month after that, your dose will go up until you get to a maintenance dose. This takes a few months. Slowly raising the dose can help reduce side effects like nausea, diarrhea, and stomach pain.
- Stomach upset is a common side effect when you first start Foundayo (orforglipron). Most times, it gets better as you keep taking the medication. To help calm your stomach, try to eat smaller portions and stay away from greasy, fried, and spicy foods. If you vomit or have diarrhea, be sure to drink plenty of fluids to stay hydrated. Tell your care team if these side effects get worse or don't go away.
- You might start to see results within 4 weeks of taking Foundayo (orforglipron) every day. But it can take several months to see the most weight loss. Everyone is different, so results might take more or less time for you. Try to be patient and keep taking the medication as prescribed, even if you don't see changes right away. Ask your prescriber if you have questions about how long until you should see results.
- Don't use other GLP-1 agonists with Foundayo (orforglipron). They have many of the same side effects. So, using them at the same time can make side effects worse.
- Share your medication list with your care team. Foundayo (orforglipron) might interact with other medications. This can raise your risk of side effects or make certain medications work less well. Also, Foundayo (orforglipron) slows down your gut. This can affect how other oral medications get absorbed into your body. Your care team can check if you need dose adjustments or if you need to avoid certain medications.
- Store Foundayo (orforglipron) at room temperature (68ºF to 77ºF). Keep the medication in the original bottle and carton to protect it from light.
- If you miss a dose of Foundayo (orforglipron): Take the medication as soon as possible. Don't double up your next dose because this can raise your risk of side effects. If you miss your dose for 7 or more days in a row, reach out to your prescriber. They might need to restart you on a lower dose and bring you back up to your usual dose. This helps prevent stomach-related side effects.
- If you can get pregnant: It's recommended to use non-oral birth control, like a vaginal ring or an intrauterine device (IUD). You can also add a barrier method like condoms during sex. Use these methods for 30 days after starting Foundayo (orforglipron) and for 30 days after each time your dose goes up. The medication can make birth control pills work less well at preventing pregnancy during that time.
- If you become pregnant while taking Foundayo (orforglipron): Tell your prescriber right away. You're encouraged to join Eli Lilly's pregnancy registry. This program helps track your health and your baby's health if you've taken the medication while pregnant. Talk to your prescriber or call Eli Lilly at 1-800-545-5979 to learn more.
- If you plan to breastfeed: It isn't recommended to take Foundayo (orforglipron) while breastfeeding. We don't know if it can pass into breast milk or how it could affect your milk supply or your baby. Talk to your prescriber about the risks and benefits of breastfeeding while taking Foundayo (orforglipron). They can talk with you about safer feeding options if you need to take this medication while nursing.
More on Foundayo (orforglipron) tips
Risks and warnings for Foundayo (orforglipron)
Foundayo (orforglipron) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Possible risk of thyroid cancer
In animal studies, GLP-1 medications like Foundayo (orforglipron) were linked to a higher risk of thyroid cancer in rats and mice. But when they were given Foundayo (orforglipron), these animals didn't get tumors. It's not clearly known if Foundayo (orforglipron) can cause thyroid cancer in people.
Because of this possible risk, people with a personal or family history of medullary thyroid cancer (MTC) shouldn't take Foundayo (orforglipron). People with multiple endocrine neoplasia syndrome type 2 (MEN 2) also shouldn't take this medication.
Talk to your prescriber if you're worried about the risk of thyroid cancer with Foundayo (orforglipron). Call your care team right away if you notice a lump in your neck. Also tell them if you have trouble swallowing, shortness of breath, or a hoarse voice that doesn't go away. These can be signs of thyroid cancer.
Severe stomach side effects
- Risk factors: History of gastroparesis
Foundayo (orforglipron) often causes stomach-related side effects like nausea, vomiting, diarrhea. But in some cases, it can be severe. Let your care team know right away if these side effects get too bothersome or start to become severe.
Foundayo (orforglipron) isn't recommended if you have gastroparesis, a gut condition that slows down how your stomach empties. Tell your prescriber if you’ve had stomach problems before starting this medication.
Kidney damage
- Risk factors: Side effects like nausea, vomiting, or diarrhea | Dehydration
Although rare, some people taking Foundayo (orforglipron) have had kidney damage. This sometimes led them to need dialysis. Most times, kidney damage happened in people who had nausea, vomiting, or diarrhea from the medication.
Tell your prescriber if you have side effects like nausea, vomiting, or diarrhea while taking Foundayo (orforglipron). These can raise your risk of dehydration, which can sometimes lead to kidney damage. If you have these side effects, you might need to get blood tests done every so often to check for kidney damage.
Inflammation of the pancreas (pancreatitis)
Some people taking Foundayo (orforglipron) have had swelling or inflammation in the pancreas. This is called pancreatitis. It can sometimes cause serious damage to the pancreas or bleeding.
Stop taking Foundayo (orforglipron) and call your care team if you have symptoms of pancreatitis. This includes vomiting or severe stomach pain that travels to your back and doesn't go away.
Gallbladder problems
Although it's rare, some people who take Foundayo (orforglipron) can have gallbladder problems. This can include an inflamed gallbladder or gallstones. Tell your care team if you notice symptoms of gallbladder problems. Look out for yellow skin or eyes, fever, chills, or severe pain in your upper right stomach.
Low blood sugar
- Risk factors: Type 2 diabetes | Taking insulin or certain other diabetes medications that can lower blood sugar
Foundayo (orforglipron) can lower your blood sugar. Taking it with diabetes medications like insulin or glipizide could put you at greater risk. Blood sugar that drops too low can be dangerous.
Your care team might ask you to check your blood sugar while taking Foundayo (orforglipron), especially if you have Type 2 diabetes. Tell your prescriber if you take any diabetes medications. They might need to adjust your diabetes treatment to keep you safe.
You and your loved ones should know how to spot low blood sugar and how to treat it. Signs can include feeling very hungry, shaky, weak, or confused. You might also sweat a lot or have a racing heart or changes in vision. If you still have low blood sugar after trying to treat it, call 911 right away.
Allergic reactions
It's possible to have a serious allergic reaction to Foundayo (orforglipron). This can include swelling of your face or throat or even anaphylaxis. Tell your prescriber if you've had a reaction to other GLP-1 agonists.
Call 911 right away if you have an allergic reaction after taking Foundayo (orforglipron). Watch for swelling in your face or throat, trouble breathing, or hives.
Eye problems in people with Type 2 diabetes (diabetic retinopathy)
- Risk factors: History of eye problems caused by high blood sugar | Type 2 diabetes | Rapid improvement in blood sugar
If you have an eye problem called diabetic retinopathy, let your prescriber know. Also tell your eye specialist that you're taking Foundayo (orforglipron).
Foundayo (orforglipron) can lower your blood sugar. When blood sugar improves too fast, it's possible for these eye problems to get worse for a short time. Talk to your prescriber or eye specialist if your eye problems get worse while taking Foundayo (orforglipron). Also tell them if you notice any changes in your vision.
Lung problems during general anesthesia or deep sedation
While under general anesthesia or deep sleep, some people taking GLP-1 agonists like Foundayo (orforglipron) had a serious lung problem. This happened when food or liquid got into the lungs.
Although rare, this lung problem can happen because Foundayo (orforglipron) slows down your digestion. So even if you followed instructions not to eat or drink before your procedure, food might still be in your stomach and could get into the lungs.
Before any surgery or medical procedure, tell the care team you're taking Foundayo (orforglipron). They can watch for this lung problem and help keep you safe during the procedure.
Foundayo (orforglipron) dosage
The average cost for 30 tablets of 0.8mg of Foundayo (orforglipron) is $25.00 with a free GoodRx coupon. This is 96.80% off the average retail price of $780.47. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.8mg | 30 tablets | $25.00 | $0.83 |
| 2.5mg | 30 tablets | $25.00 | $0.83 |
| 5.5mg | 30 tablets | $25.00 | $0.83 |
| 9mg | 30 tablets | $25.00 | $0.83 |
| 14.5mg | 30 tablets | $25.00 | $0.83 |
| 17.2mg | 30 tablets | $25.00 | $0.83 |
Typical dosage for Foundayo (orforglipron)
Your prescriber will raise your dose every 30 days (1 month) until you reach the maintenance dose. Don't take more than 1 tablet each day.
The typical dosing schedule is listed below.
- Month 1: Take 0.8 mg by mouth once a day.
- Month 2: Take 2.5 mg by mouth once a day.
- Month 3: Take 5.5 mg by mouth once a day.
- Month 4 and beyond: If needed, your prescriber might raise your dose stepwise to 9 mg, 14.5 mg, or 17.2 mg once a day after at least 30 days at each dose. They'll choose your dose based on how well it works and if you have side effects.
The maximum dose is 17.2 mg by mouth once a day. This might differ if you take certain medications that interact with Foundayo (orforglipron).
More on Foundayo (orforglipron) dosage
How much does Foundayo (orforglipron) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Foundayo (brand)
$25.00
Foundayo (orforglipron) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Foundayo (orforglipron) will not be safe for you to take.
- Personal or family history of medullary thyroid cancer (MTC)
- Multiple endocrine neoplasia syndrome type 2 (MEN 2)
What are alternatives to Foundayo (orforglipron)?
There are a number of medications that your doctor can prescribe in place of Foundayo (orforglipron). Compare a few possible alternatives below.
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