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Eliquis Coupon - Eliquis 5mg tablet

Eliquis

apixaban
Used for Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism, Stroke Risk Reduction

Eliquis (apixaban) is an anticoagulant (blood thinner) used to prevent and treat blood clots. It can lower the risk of serious conditions like stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE). The medication comes as a tablet or liquid and is taken by mouth twice a day. Common side effects include bleeding and bruising. Although generic versions have been approved by the FDA, they might not be available until 2026.

Reviewed by:
reviewerDaisy Chau, PharmD
reviewerAllison Gourley, PharmD
Last reviewed on June 6, 2025
basics-icon

What is Eliquis (apixaban)?

Featuring Nabila Ismail, PharmDReviewed by Cydnee Ng, PharmD | July 31, 2024

What is Eliquis (apixaban) used for?

Adults:

Children:

  • Treat blood clots and lower the risk of new clots in children from birth and older

How Eliquis (apixaban) works

Eliquis (apixaban) is a direct-acting oral anticoagulant (DOAC) that works by blocking factor Xa, a protein your body uses to form clots. By stopping this protein, Eliquis (apixaban) helps thin your blood and prevent clots from forming or getting bigger.

When does Eliquis (apixaban) start working?Time passed since treatment started:
HOURS
Full effect
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsEliquis, Eliquis Sprinkle
Drug ClassDirect-acting oral anticoagulant (DOAC)
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
side-effects-icon

Side effects of Eliquis (apixaban)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Adults:

  • Any bleeding (up to 15%)

Children:

  • Any bleeding (up to 36%)
  • Headache (16%)
  • Vomiting (14%)

Less Common Side Effects

  • Nausea

Eliquis (apixaban) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious bleeding: bleeding that won’t stop, blood in the urine or stool, coughing or vomiting blood, unexplained bruises, bruises that get bigger, dizziness
  • Bleeding around the spine (spinal or epidural hematoma): back pain, weakness, difficulty walking, loss of bowel or bladder control, paralysis
When do Eliquis (apixaban) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Risk of nosebleeds
Risk of bruising
Risk of bleeding
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Eliquis (apixaban) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Blood in the eyes

blood in the urine

bloody or black, tarry stools

bruising or purple areas on the skin

confusion

constipation

coughing up blood

decreased alertness

difficulty swallowing

dizziness

fainting

fast heartbeat

headache

hives, itching, skin rash

joint pain or swelling

nausea and vomiting

nosebleeds

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of the eye

severe stomach pain

shortness of breath

tightness in the chest

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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pros-and-cons-icon

Pros and cons of Eliquis (apixaban)

Pros

  • No regular blood monitoring required
  • Can be taken with or without food
  • Approved for both children and adults

Cons

  • Need to take it twice a day
  • Most common side effect is bleeding
  • Not easily reversible in life-threatening bleeds
pharmacist-tips-icon

Pharmacist tips for Eliquis (apixaban)

pharmacist
  • Don't stop taking Eliquis (apixaban) unless your prescriber says it's safe. Stopping suddenly can cause serious or life-threatening blood clots.
  • You can take Eliquis (apixaban) with or without food. Try to take it at the same time every day to help you stay on schedule.
  • The most common side effect of Eliquis (apixaban) is bleeding and bruising more easily than usual. Stop taking it and get medical help right away if you feel lightheaded, vomit or cough up blood, or see blood in your stool. These could be signs of serious bleeding.
  • If you need surgery or a procedure, even dental work, tell your care team you're taking Eliquis (apixaban) because you may need to stop it for a short time to lower your risk of bleeding. Your prescriber will usually have you stop it 1 to 2 days before and tell you when it’s safe to start again.
  • If you're having trouble swallowing Eliquis (apixaban) tablets, you can crush them and mix with water, apple juice, or applesauce and take them right away since the crushed tablets are only good for up to 4 hours.
  • If your child is taking Eliquis (apixaban) Sprinkle capsules, you can open them and mix the contents with water or infant formula. Use the mixture within 2 hours. These capsules shouldn't be swallowed whole.
  • If your child is taking Eliquis (apixaban) tablet in a packet, mix it with water, infant formula, apple juice, or applesauce and give it right away since the mixed solution is only good for up to 4 hours. You can also give it through a feeding tube if needed.
  • Eliquis (apixaban) can interact with many medications. Tell your care team if you're taking any prescription, over-the-counter medications, or supplements during treatment.
  • Eliquis (apixaban) can raise the risk of heavy uterine bleeding. If you're planning to become pregnant, talk to your prescriber before starting this medication.
  • It’s not known if Eliquis (apixaban) passes into breast milk or if it’s safe while breastfeeding. Since the risk is unknown, breastfeeding isn't recommended while taking this medication. Talk to your prescriber about safer options during this time.
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faq-icon

Common questions about Eliquis (apixaban)

Yes, Eliquis is a type of blood thinner called an anticoagulant. It helps lower the risk of unwanted blood clots. Eliquis works by stopping a certain clotting factor (protein) in your body from working. This causes less blood clots to form. Learn more

Eliquis is FDA approved to prevent and treat unwanted blood clots. It can be used to lower the risk of blood clots and stroke in people with atrial fibrillation (AFib) not caused by heart valve problems. It's also used to lower the risk of blood clots in deep veins of the body — known as deep vein thrombosis (DVT) — after hip or knee replacement surgery. Eliquis may also be prescribed to treat a DVT or pulmonary embolism (PE), or lower the risk of a repeat DVT or PE.Learn more

Minor bleeding is one of the most common side effects of Eliquis. Minor bleeding includes nosebleeds, light bruising, and bleeding from the gums when brushing your teeth. Menstruation may also be a bit heavier or last longer than usual. The amount of blood loss should be small and stop on its own. Other common Eliquis side effects include nausea, constipation, and anemia (low red blood cells).Learn more

There aren’t many dietary restrictions you have to follow while taking Eliquis. That being said, there are several foods (mainly herbs and spices) and supplements that may make bleeding more likely if you combine them with Eliquis. These include: cayenne pepper, garlic, ginger, grapeseed oil, turmeric, vitamin E, and ginkgo biloba. Consuming these ingredients in moderate amounts with Eliquis is unlikely to be an issue. But in large amounts, or in supplement form, they may increase your chances of bleeding. Learn more

Yes, Eliquis is considered a high-risk or high-alert medication. This is because it raises the risk of serious bleeding, which can be fatal in the most severe cases.Learn more

Eliquis raises your risk of bleeding. Most people experience minor bleeding while taking Eliquis. Minor bleeding includes nosebleeds, light bruising, and bleeding from the gums when brushing your teeth. The amount of blood loss should be small and stop on its own. While rare, Eliquis can cause serious or life-threatening bleeding. Contact your healthcare team right away if you notice bleeding that’s taking longer than usual to stop.Learn more
warnings-icon

Risks and warnings for Eliquis (apixaban)

Eliquis (apixaban) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Higher risk of blood clots if stopped too early

  • Risk factors: Certain heart conditions

Black Box Warning If you stop taking Eliquis (apixaban) too soon without speaking with your prescriber, your risk of dangerous blood clots might go up. If you need to stop the medication for any reason other than bleeding or finishing treatment, your prescriber might have you start on another blood thinner to help keep you protected.

Paralysis in the spine

  • Risk factors: Spinal surgery or spinal tap | Use of indwelling epidural catheter | Anesthesia in the spine (epidural)

Black Box Warning If you’re taking Eliquis (apixaban) and need spinal or epidural anesthesia (numbing around your spine) or a spinal tap, you might have a higher risk of bleeding near your spine. This type of bleeding, called a spinal or epidural hematoma, is rare but can cause long-term or permanent paralysis. Your care team will explain how to safely stop Eliquis (apixaban) before the procedure to help lower this risk. Call your prescriber right away if you notice back pain, weakness, numbness, difficulty walking, or a loss of bowel or bladder control.

Bleeding

  • Risk factors: Taking other blood thinners or NSAIDs | Taking medications that can cause bleeding

Since Eliquis (apixaban) is a blood thinner, it can raise your risk of bleeding, including serious and life-threatening bleeding. You might bruise more easily, and bleeding might take longer to stop. Your risk of bleeding is higher if you have certain other medical conditions or take other medications that cause bleeding. Get medical help right away if you or your child have bleeding that doesn't stop, blood in your urine or stool, coughing or vomiting blood, or feel dizzy or lightheaded.

There are medications, such as Andexxa (andexanet alfa), that can reverse the effects of Eliquis (apixaban) in an emergency. But these reversal medications are given through a vein (intravenously, IV) and are usually only available in the hospital. It's very important that all healthcare professionals, including emergency responders, know you're taking Eliquis (apixaban). Wearing a medical alert bracelet that lists this medication can help keep you safe.

Not recommended in people with prosthetic heart valves

Eliquis (apixaban) hasn’t been studied in people with artificial heart valves. Because of this, it’s not recommended for people who have a prosthetic heart valve.

Not recommended in people with antiphospholipid syndrome

Eliquis (apixaban) isn't recommended for people with triple-positive antiphospholipid syndrome (APS) because it's been linked to a higher chance of blood clots coming back. If you have APS, your prescriber will likely recommend a different medication to help reduce your risk for clots.

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Eliquis (apixaban) dosage

The average cost for 60 tablets of 5mg of Eliquis (apixaban) is $341.19 with a free GoodRx coupon. This is 55.22% off the average retail price of $761.96.
cartonCarton
DosageQuantityPrice as low asPrice per unit
30-Day Starter Pack of 5mg1 carton$417.42$417.42
tabletTablet
DosageQuantityPrice as low asPrice per unit
2.5mg60 tablets$340.99$5.68
5mg60 tablets$341.19$5.69

Typical dosage for Eliquis (apixaban)

Adults:

How long you take Eliquis (apixaban) is based on why you're taking it. Your dose might be lower depending on your age, weight, and kidney health.

  • Lower the risk of a stroke in AFib: The typical dose is 5 mg by mouth twice a day.
  • Treat DVT or PE: The typical dose is to start with 10 mg by mouth twice a day for 7 days, then switch to 5 mg twice a day.
  • Lower the risk of DVT or PE coming back: The typical dose is 2.5 mg by mouth twice a day.
  • Prevent DVT or PE in people with recent surgery:
    • Hip replacement surgery: The typical dose is 2.5 mg by mouth twice a day for 35 days.
    • Knee replacement surgery: The typical dose is 2.5 mg by mouth twice a day for 12 days.

Children:

The dose is based on your child's weight, and the medication is taken by mouth twice a day.

interactions-icon

Interactions between Eliquis (apixaban) and other drugs

Eliquis (apixaban) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Eliquis (apixaban). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Defibrotide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Eliquis (apixaban) cost?

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contraindications-icon

Eliquis (apixaban) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Eliquis (apixaban) will not be safe for you to take.

  • Active bleeding
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What are alternatives to Eliquis (apixaban)?

There are a number of medications that your doctor can prescribe in place of Eliquis (apixaban). Compare a few possible alternatives below.
Eliquis (apixaban)
Used for:

Adults:

Children:

  • Treat blood clots and lower the risk of new clots in children from birth and older
$340.99Lowest GoodRx priceView prices
Used for:
  • Prevention and treatment blood clots in the veins
  • Prevention and treatment blood clots linked to atrial fibrillation (AFib) or heart valve replacement
  • Prevention of more blood clots and to lower risk of death after a heart attack
$4.00Lowest GoodRx priceView prices
Used for:

Adults:

Children:

$49.72Lowest GoodRx priceView prices
latest-news-icon

News about Eliquis (apixaban)

You don’t need to follow a certain diet when taking Eliquis, but large amounts of herbs like garlic or ginger may interact with it. Learn more about taking Eliquis here.
What Foods Should You Avoid While Taking Eliquis? Answers to This and 7 More Eliquis FAQs
You don’t need to follow a certain diet when taking Eliquis, but large amounts of herbs like garlic or ginger may interact with it. Learn more about taking Eliquis here.
Eliquis is a blood thinner that can help prevent blood clots. However, a few of its interactions could actually increase your risk of blood clots or bleeding.
11 Eliquis (Apixaban) Interactions You Should Know About
Eliquis is a blood thinner that can help prevent blood clots. However, a few of its interactions could actually increase your risk of blood clots or bleeding.
Eliquis, or apixaban, is a blood clot medication that can prevent strokes. Here’s our dosage guide for taking Eliquis safely, side effects, and when to stop.
Eliquis Dosages for Adults: Your GoodRx Guide
Eliquis, or apixaban, is a blood clot medication that can prevent strokes. Here’s our dosage guide for taking Eliquis safely, side effects, and when to stop.
The cost of blood thinners varies by medication, dosage, and other factors. Learn more about blood thinner prices with this savings guide from GoodRx.
A GoodRx Savings Guide to 4 Types of Blood Thinner Medications
The cost of blood thinners varies by medication, dosage, and other factors. Learn more about blood thinner prices with this savings guide from GoodRx.
Eliquis is used to treat and prevent blood clots. See what affects the cost of Eliquis, how insurance covers Eliquis, and how you can save.
How Much Is Eliquis Without Insurance?
Eliquis is used to treat and prevent blood clots. See what affects the cost of Eliquis, how insurance covers Eliquis, and how you can save.
If you’ve been diagnosed with a pulmonary embolism, your treatment, recovery, and prognosis will depend on many factors. Explore potential outcomes here.
Pulmonary Embolism (Blood Clot in the Lung): Treatment and Recovery
If you’ve been diagnosed with a pulmonary embolism, your treatment, recovery, and prognosis will depend on many factors. Explore potential outcomes here.
Pradaxa and Eliquis are both blood thinners, but there are some key differences between them. Learn more about Pradaxa versus Eliquis with this guide.
Pradaxa vs. Eliquis: 5 Key Differences to Consider
Pradaxa and Eliquis are both blood thinners, but there are some key differences between them. Learn more about Pradaxa versus Eliquis with this guide.
Warfarin and Eliquis are blood thinners used to treat and prevent unwanted blood clots. Compare how these anticoagulants work, risks, benefits, and cost.
Warfarin vs. Eliquis: 7 Differences Between These Blood Thinner Medications
Warfarin and Eliquis are blood thinners used to treat and prevent unwanted blood clots. Compare how these anticoagulants work, risks, benefits, and cost.
Deep vein thrombosis causes blood clots to form, normally in the leg. Learn more about the treatments used to ease and prevent this condition.
What Are the Best Deep Vein Thrombosis (DVT) Treatments and Medications?
Deep vein thrombosis causes blood clots to form, normally in the leg. Learn more about the treatments used to ease and prevent this condition.
Eliquis is used to treat and prevent blood clots. Its most common side effect is unwanted bleeding. But there are other side effects you should also be aware of.
7 Eliquis Side Effects You Should Know About
Eliquis is used to treat and prevent blood clots. Its most common side effect is unwanted bleeding. But there are other side effects you should also be aware of.
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Eliquis (apixaban) images

Pink Oval 894 And 5 - Eliquis 5mg Tablet
This medicine is Pink, Oval Tablet Imprinted With "5" And "894".Pink Oval 894 And 5 - Eliquis 5mg Tablet

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References

Best studies we found

Brown, M. A., et al. (2013). Coagulation factor Xa. Handbook of Proteolytic Enzymes.

E.R. Squibb & Sons, L.L.C. (2025). Eliquis- apixaban tablet, film coated; Eliquis 30-day starter pack - apixaban kit [package insert]. DailyMed.

Hurst, K. V., et al. (2017). Quick reference guide to apixaban. Vascular Health and Risk Management.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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