Andexxa

Andexxa (andexanet alfa) is a manmade form of coagulation factor Xa, a protein naturally found in your blood that's important for blood clotting. It attaches to blood thinners called Xarelto (rivaroxaban) and Eliquis (apixaban) to stop them from working in your body. Andexxa (andexanet alfa) also helps raise levels of thrombin, an enzyme involved with blood clotting.

No. Andexxa (andexanet alfa) is only available as an injection that's given through your vein by a trained healthcare provider. You can't get a prescription to have it at home in case of a bleeding event while you're taking Xarelto (rivaroxaban) or Eliquis (apixaban). If you get a serious or uncontrollable bleed while taking blood thinners, get medical help right away so you can be treated.

The most common side effects reported by people who were given Andexxa (andexanet alfa) were urinary tract infections (UTIs), pneumonia, and infusion-related reactions. Symptoms of infusion-related reactions included flushing, feeling hot, cough, change in taste, and shortness of breath. Most people (90%) didn't require any treatment for their reaction.

Since Andexxa (andexanet alfa) stops certain blood thinners from working, treatment with this medication has been linked to blood clots, poor blood flow to parts of the body, heart attack, stroke, and cardiac arrest (when the heart stops beating suddenly). These life-threatening side effects typically happen around a few days to a week after receiving Andexxa (andexanet alfa), but could appear later. Your provider will monitor you for blood clots and restart your blood-thinning medications as soon as possible to prevent them from happening.