Edurant (rilpivirine) is a once-daily antiretroviral medication that's taken by mouth and is used to treat human immunodeficiency virus (HIV) infection. It's approved for use in adults and children. Edurant (rilpivirine) is taken with other antiretroviral medications when it's used for certain people who've never had HIV treatment before. Edurant (rilpivirine) can also be used for a short period of time before starting Cabenuva (cabotegravir / rilpivirine). Side effects of Edurant (rilpivirine) can include depression, headache, and trouble sleeping.
Edurant (rilpivirine) is an HIV antiretroviral medication that's known as a non-nucleoside reverse transcriptase inhibitor (NNRTI). It blocks an enzyme called reverse transcriptase that helps HIV make copies of itself. By blocking this enzyme, the medication prevents HIV from spreading.
| Common Brands | Edurant |
|---|---|
| Drug Class | HIV ARV |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Note: Side effects were reported by people who took Edurant (rilpivirine) with other HIV antiretroviral medications.
Contact your healthcare provider immediately if you experience any of the following.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
More tips for Edurant (rilpivirine) Peds:
Edurant (rilpivirine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Edurant (rilpivirine) can sometimes cause rash and other severe skin reactions. In rare cases, these skin reactions can lead to hospitalization and other complications. Severe skin reactions can happen at any time while you're taking Edurant (rilpivirine), but they're most common within 4 to 6 weeks of starting treatment. Get medical care right away if you have a rash, blistering, peeling skin, mouth sores, swelling, or trouble breathing.
Note that certain severe allergic reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS), can happen with or without a rash. Although these reactions are rare, they can cause organ failure or blood problems. Get medical help as soon as possible if you have signs like sudden rash, mouth sores, fever, chills, body aches, or swollen lymph nodes.
Some people have had liver problems while they were taking Edurant (rilpivirine). This risk might be higher if you've had past liver problems like hepatitis. Talk with your care team about your medical history before you start this medication to find the safest treatment option for you. You’ll need to get blood tests done while you take Edurant (rilpivirine) so your care team can check your liver health. Talk with your primary care provider or HIV specialist if you have signs and symptoms of liver damage, such as feeling sleepy, upper right stomach pain, yellowing of the skin or whites of the eyes, or dark urine.
Some people have experienced depression, mood swings, and suicidal thoughts or attempt(s) while they were taking Edurant (rilpivirine). These mental health changes were mild or moderate during studies. Call your care team if you notice any mood changes. Your care team can try to see whether your symptoms are related to this medication. They'll also decide whether Edurant (rilpivirine) is still safe for you to continue taking. Call 911 right away if you or a loved one notices that you have suicidal thoughts or behavior.
Taking Edurant (rilpivirine) with other antiretroviral medications can cause changes to your immune system and lead to immune reconstitution syndrome. This medical condition happens when your immune system becomes more active after you start HIV treatment. Your immune system begins to fight off different infections that it was too weak to fight off before you started treatment.
In rare cases, your immune system might improve so much with treatment that it starts to attack normal cells in your body. This can lead to autoimmune problems, which can appear as early as during the first few weeks of starting treatment or many months later. Tell your care team right away if you start having any new symptoms, such as fever, pain, hair loss, bulging eyes, or sweating, after you start Edurant (rilpivirine).
Edurant (rilpivirine) interacts with many medications. Some medications can cause the amount of Edurant (rilpivirine) in your body to drop. This can make the HIV medication work less well to treat your infection. Examples of medications to avoid because of this risk include certain medications for seizures (e.g., carbamazepine (Tegretol)), dexamethasone (more than one dose), St. John’s wort, and certain antibiotics (e.g., rifampin (Rifadin)).
Edurant (rilpivirine) can also raise the amount of other medications in your body when taken together. This raises your risk for side effects from those other medications. For example, taking Edurant (rilpivirine) with antibiotics like clarithromycin or erythromycin can put you at risk for serious heart problems.
Because of the potential for serious interactions with Edurant (rilpivirine) and various medications, let your care team know what other medications you’re taking or planning to take with Edurant (rilpivirine). Your care team can make sure your medications are safe to take together.
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 25mg of | 30 tablets | $408.82 | $13.63 |
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Edurant (rilpivirine) will not be safe for you to take.
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How long Edurant side effects last can differ depending on which side effects you're experiencing. For example, some people can have side effects like nausea, trouble sleeping, and fatigue; these side effects typically start to improve or go away after a few days or weeks of treatment. Keep in mind that not all side effects will go away on their own and you might sometimes need more medical attention (such as with side effects like depression or liver problems). Talk with your care team if you're struggling with a particular side effect of Edurant.
Avoid taking Edurant with certain heartburn medications, such as omeprazole (Prilosec). This is because proton pump inhibitors (PPIs), like omeprazole (Prilosec) and lansoprazole (Prevacid), raise how acidic your stomach gets. This can lower the amount of Edurant that gets absorbed into the body, which can cause the medication to work less well and worsen your HIV-1 infection. Speak with your HIV specialist or a pharmacist about alternative heartburn medications and how to safely take them with Edurant.
For those who haven't been treated with HIV before, Edurant is safe to use in children 2 years and older who weigh at least 30 pounds. For short-term treatment of HIV infection, the medication is approved for children 12 years and older who weigh at least 77 pounds. Tell your child's HIV care team if your child has any significant weight loss during treatment with Edurant. Also let the care team know if your child has nausea, vomiting, or diarrhea that won’t go away since severe cases of these side effects can contribute to weight loss.
Yes. It seems like Edurant doesn't raise the risk of harm to your unborn baby. If you become pregnant while taking Edurant, your HIV specialist might recommend continuing the medication at 25 mg by mouth once a day. In addition, you’re encouraged to enroll in the Antiretroviral Pregnancy Registry (APR). This registry monitors and collects information about your health and your baby's health while you're taking Edurant. Learn more about this registry by calling 1-800-258-4263.
Medications containing rilpivirine can cause serious skin and allergic reactions. Taking Edurant — the tablet form of rilpivirine — before you start getting injections of Cabenuva (cabotegravir / rilpivirine) can help your care team see how your body reacts to the ingredients of Cabenuva. If you have a reaction to rilpivirine, it's a lot easier for your body to get rid of the medication in the tablet form than in injection form (which lasts longer in the body). Your HIV specialist will typically prescribe Edurant for about a month before you start Cabenuva injections. Once you've started getting routine Cabenuva injections, you won't have to take any more daily Edurant tablets. Talk with your care team if you have questions about how to transition from the tablets to the injections.
