Medications for nasal polyps are used to treat this condition and chronic rhinosinusitis with or without nasal polyps. They work by lessening inflammation and shrinking the polyps to improve breathing and other symptoms. Common classes include corticosteroids and interleukin antagonists. Corticosteroids are usually used in the nose. For example, Xhance (fluticasone) is a nasal spray and Sinuva (mometasone) is an implant placed in the nasal passages. Interleukin antagonists, such as Dupixent (dupilumab), are given as injections. These treatments offer different ways to help manage your nasal polyps effectively.